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TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287299((2S,4S)-5-Biphenyl-4-yl-4-(4-carboxymethyl-thiazol...)
Affinity DataIC50: 0.690nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35751(cis-1,2-diaminocyclohexane derivative, 8h)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255631(N-[(1R,2R,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35756(cis-1,2-diaminocyclohexane derivative, 8m)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255577(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255205(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286907((S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl)-pe...)
Affinity DataIC50: 2.30nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255207(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255159(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286905((S)-5-Biphenyl-4-yl-4-(1-carboxy-ethylcarbamoyl)-2...)
Affinity DataIC50: 2.80nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286905((S)-5-Biphenyl-4-yl-4-(1-carboxy-ethylcarbamoyl)-2...)
Affinity DataIC50: 2.80nMAssay Description:In vitro inhibition of neutral endopeptidase from rat kidney.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255204(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286906((2S,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Affinity DataIC50: 3.20nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35759(cis-1,2-diaminocyclohexane derivative, 8p)
Affinity DataIC50: 3.20nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286906((2S,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Affinity DataIC50: 3.20nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286906((2S,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Affinity DataIC50: 3.20nMAssay Description:In vitro inhibition of neutral endopeptidase from rat kidney.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287301((2R,4S)-5-Biphenyl-4-yl-4-(4-carboxymethyl-thiazol...)
Affinity DataIC50: 3.30nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255576(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255575(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255206(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35753(cis-1,2-diaminocyclohexane derivative, 8j)
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255578(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255158(N-[(1R,2S,5S)-5-(tert-Butylcarbamoyl)-2-{[(5-chlor...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35754(cis-1,2-diaminocyclohexane derivative, 8k)
Affinity DataIC50: 4.80nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255579(N-[(1R,2S,5S)-5-Acetyl-2-{[(5-chloroindol-2-yl)car...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35755(cis-1,2-diaminocyclohexane derivative, 8l)
Affinity DataIC50: 5.70nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286908((2R,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Affinity DataIC50: 5.90nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286906((2S,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Affinity DataIC50: 5.90nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286908((2R,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Affinity DataIC50: 5.90nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35748(cis-1,2-diaminocyclohexane derivative, 8e)
Affinity DataIC50: 6.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287304((S)-5-Biphenyl-4-yl-2-phenoxymethyl-4-(1H-tetrazol...)
Affinity DataIC50: 7.40nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255574(cis-(1S)-4-(5-chloro-1H-indole-2-carboxamido)-3-(5...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286909((S)-5-Biphenyl-4-yl-4-((R)-1-carboxy-ethylcarbamoy...)
Affinity DataIC50: 8.70nMAssay Description:In vitro inhibition of neutral endopeptidase from rat kidney.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50286909((S)-5-Biphenyl-4-yl-4-((R)-1-carboxy-ethylcarbamoy...)
Affinity DataIC50: 8.70nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287300(2-[(S)-3-Biphenyl-4-yl-2-(4-carboxymethyl-thiazol-...)
Affinity DataIC50: 9.80nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287300(2-[(S)-3-Biphenyl-4-yl-2-(4-carboxymethyl-thiazol-...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255580(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35758(cis-1,2-diaminocyclohexane derivative, 8o)
Affinity DataIC50: 15nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50214995(cis-N-(2-(5-chloro-1H-indole-2-carboxamido)cyclohe...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287297((S)-5-Biphenyl-4-yl-2-phenoxymethyl-4-[(1H-tetrazo...)
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35757(cis-1,2-diaminocyclohexane derivative, 8n)
Affinity DataIC50: 37nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35752(cis-1,2-diaminocyclohexane derivative, 8i)
Affinity DataIC50: 49nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35750(cis-1,2-diaminocyclohexane derivative, 8g)
Affinity DataIC50: 55nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287302((S)-5-Biphenyl-4-yl-4-(4-carboxymethyl-thiazol-2-y...)
Affinity DataIC50: 58nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50403562(UK-69578 | CHEMBL2062138)
Affinity DataIC50: 65nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35749(cis-1,2-diaminocyclohexane derivative, 8f)
Affinity DataIC50: 69nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
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