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TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 1.20nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16313(IDD594 | LdT | CHEMBL395347 | {2-[(4-bromo-2-fluor...)
Affinity DataIC50: 3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM200221(2-(5-chloro-2-(((perbromophenyl)methyl)carbamoyl)p...)
Affinity DataIC50: 30nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 60nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM200221(2-(5-chloro-2-(((perbromophenyl)methyl)carbamoyl)p...)
Affinity DataIC50: 80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50029207(phenethyl 3-(3,4-dihydroxyphenyl)acrylate | caffei...)
Affinity DataIC50: 80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM200221(2-(5-chloro-2-(((perbromophenyl)methyl)carbamoyl)p...)
Affinity DataIC50: 80nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585957(CHEMBL5076191)
Affinity DataKi:  240nMAssay Description:Competitive inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 using 4-NBA and NADP+ as substrate by Michaelis-Menten based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585950(CHEMBL5075900)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM69358(SMR000383989 | 3-nitro-4-pyrrolidin-1-ylbenzaldehy...)
Affinity DataIC50: 270nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM104022(MK319)
Affinity DataIC50: 300nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585951(CHEMBL5086460)
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585956(CHEMBL5082977)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 using 4-NBA and NADP+ as substrate by Michaelis-Menten based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585952(CHEMBL5090970)
Affinity DataIC50: 310nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16238(IDD388 | {2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-...)
Affinity DataIC50: 400nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM200220(2-(5-chloro-2-((2,4,6-tribromobenzyl)carbamoyl)phe...)
Affinity DataIC50: 430nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM200222(2-(2,4-dioxo-3-(2,3,4,5-tetrabromo-6-methoxybenzyl...)
Affinity DataIC50: 450nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585949(CHEMBL5083058)
Affinity DataKi:  460nMAssay Description:Competitive inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as increase in Km without change in Vmax using hexanal as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50076742(CHEBI:86194 | CHEMBL3416563)
Affinity DataIC50: 480nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A1 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [L301M](Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 500nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMed
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585953(CHEMBL5087589)
Affinity DataIC50: 550nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 620nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585949(CHEMBL5083058)
Affinity DataIC50: 630nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM104020(MK181)
Affinity DataIC50: 710nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase 1A1(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585947(CHEMBL5093301)
Affinity DataIC50: 800nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A1 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase 1A1(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585948(CHEMBL5083538)
Affinity DataIC50: 880nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A1 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM200220(2-(5-chloro-2-((2,4,6-tribromobenzyl)carbamoyl)phe...)
Affinity DataIC50: 1.00E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585951(CHEMBL5086460)
Affinity DataKi: <1.00E+3nMAssay Description:Competitive inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as increase in Km without change in Vmax using hexanal as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585950(CHEMBL5075900)
Affinity DataKi: <1.00E+3nMAssay Description:Competitive inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as increase in Km without change in Vmax using hexanal as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM200220(2-(5-chloro-2-((2,4,6-tribromobenzyl)carbamoyl)phe...)
Affinity DataIC50: 1.00E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585947(CHEMBL5093301)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585957(CHEMBL5076191)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 assessed as reduction in NADPH production using 4-NBA and NADP+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585956(CHEMBL5082977)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 assessed as reduction in NADPH production using 4-NBA and NADP+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50405254(CHEMBL4172850)
Affinity DataIC50: 2.35E+3nMAssay Description:Inhibition of N-terminal His10-tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21 using D,L-glyceraldehyde as substrate pretreated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585954(CHEMBL5092526)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataIC50: 2.69E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16238(IDD388 | {2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-...)
Affinity DataIC50: 2.70E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50405256(CHEMBL4162669)
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of N-terminal His10-tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21 using D,L-glyceraldehyde as substrate pretreated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50405257(CHEMBL4174434)
Affinity DataIC50: 3.33E+3nMAssay Description:Inhibition of N-terminal His10-tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21 using D,L-glyceraldehyde as substrate pretreated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM104022(MK319)
Affinity DataIC50: 3.40E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM104020(MK181)
Affinity DataIC50: 3.70E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50405243(CHEMBL4166519)
Affinity DataIC50: 3.89E+3nMAssay Description:Inhibition of N-terminal His10-tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21 using D,L-glyceraldehyde as substrate pretreated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16238(IDD388 | {2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-...)
Affinity DataIC50: 4.40E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16238(IDD388 | {2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-...)
Affinity DataIC50: 4.40E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM104020(MK181)
Affinity DataIC50: 4.50E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50405242(CHEMBL4169944)
Affinity DataIC50: 4.71E+3nMAssay Description:Inhibition of N-terminal His10-tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21 using D,L-glyceraldehyde as substrate pretreated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAldehyde dehydrogenase family 1 member A3(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50585948(CHEMBL5083538)
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Human)
University of Bradford

Curated by ChEMBL
LigandPNGBDBM50076742(CHEBI:86194 | CHEMBL3416563)
Affinity DataIC50: 5.67E+3nMAssay Description:Inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 assessed as reduction in NADPH production using 4-NBA and NADP+ as substrate by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50405127(CHEMBL4177302)
Affinity DataIC50: 5.87E+3nMAssay Description:Inhibition of N-terminal His10-tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21 using D,L-glyceraldehyde as substrate pretreated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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