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TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560581(CHEMBL4792948)
Affinity DataKd:  5.40E+5nMAssay Description:Binding affinity to USP7 (unknown origin) by T2 relaxation experiment based analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560581(CHEMBL4792948)
Affinity DataKd:  5.80E+5nMAssay Description:Allosteric binding affinity to USP7 catalytic domain (unknown origin) at Met328 residues by NMR-15N-1H TROSY spectral titration analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560581(CHEMBL4792948)
Affinity DataKd:  6.80E+5nMAssay Description:Allosteric binding affinity to USP7 catalytic domain (unknown origin) at Met328, Trp285, Gly284, Gln405 and Gly313 residues by NMR-15N-1H TROSY spect...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 7nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560580(CHEMBL4759513)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human His-tagged USP7 (208 to 560 residues) expressed in Hi-five Sf9 cells using monoubiquitinated ubiquitin-rhodamine as s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50135226(CHEMBL3747473)
Affinity DataIC50: 60nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50135228(CHEMBL3746729)
Affinity DataIC50: 70nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197521(CHEMBL3922351)
Affinity DataIC50: 550nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197518(CHEMBL3747171)
Affinity DataIC50: 690nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197520(CHEMBL3921251)
Affinity DataIC50: 790nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197520(CHEMBL3921251)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197521(CHEMBL3922351)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197521(CHEMBL3922351)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50135226(CHEMBL3747473)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197520(CHEMBL3921251)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197518(CHEMBL3747171)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50135226(CHEMBL3747473)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197518(CHEMBL3747171)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50250947(CHEMBL4092976)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged N-terminal GST-tagged full length USP7 using di-ubiquitin as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant human COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560593(CHEMBL4777381)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50134243(CHEMBL3746644)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50134251(CHEMBL3746332)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560585(CHEMBL4787231)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560592(CHEMBL4742897)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50135230(CHEMBL3747438)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50134242(CHEMBL3747740)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50134244(CHEMBL3746705)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50134245(CHEMBL3746542)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50134249(CHEMBL3746507)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50134250(CHEMBL3746498)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50135226(CHEMBL3747473)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197516(CHEMBL3961576)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560584(CHEMBL4755647)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560583(CHEMBL4740119)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560582(CHEMBL4746931)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560589(CHEMBL4745448)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560591(CHEMBL4781213)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560581(CHEMBL4792948)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560586(CHEMBL4777703)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560590(CHEMBL4743789)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560588(CHEMBL4761706)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560587(CHEMBL4745914)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using di-ubiquitin as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 47(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560581(CHEMBL4792948)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of USP47 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 14(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560589(CHEMBL4745448)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of USP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 14(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560590(CHEMBL4743789)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of USP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 14(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560591(CHEMBL4781213)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of USP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 14(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560592(CHEMBL4742897)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of USP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 14(Human)
Medivir

Curated by ChEMBL
LigandPNGBDBM50560593(CHEMBL4777381)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of USP14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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