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TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144159(N-(1-Methoxy-6-m-tolyl-6H-benzo[c]chromen-8-yl)-me...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144173(N-(1-Difluoromethoxy-6-phenyl-6H-benzo[c]chromen-8...)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 2-2 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144153(N-[6-(3,5-Dimethyl-phenyl)-1-methoxy-6H-benzo[c]ch...)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13760((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 3nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM50192679((3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144164(N-[6-(3-Chloro-phenyl)-1-methoxy-6H-benzo[c]chrome...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-3 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144149(N-[6-(3-Fluoro-phenyl)-1-methoxy-6H-benzo[c]chrome...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-4 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144181(N-[6-(3,4-Dichloro-phenyl)-1-methoxy-6H-benzo[c]ch...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-4 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144149(N-[6-(3-Fluoro-phenyl)-1-methoxy-6H-benzo[c]chrome...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 3-4 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]progesterone from human Progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13756((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13761((1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylprop...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13768(N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]ada...)
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13756((1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)ada...)
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192679((3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192792(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 5nMAssay Description:Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13760((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13761((1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylprop...)
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 6nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144177(N-[1-Methoxy-6-(3-methoxy-phenyl)-6H-benzo[c]chrom...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 5-6 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144150(N-(1-Methoxy-6-thiophen-2-yl-6H-benzo[c]chromen-8-...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 6-8 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144147(N-(1-Methoxy-6-p-tolyl-6H-benzo[c]chromen-8-yl)-me...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 6-7 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13757((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 8nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13757((1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 8nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13769(2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[...)
Affinity DataIC50: 8nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192679((3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13770(2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymet...)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13772(2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R...)
Affinity DataIC50: 10nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192797(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidaz...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144160(N-[6-(4-Chloro-phenyl)-1-methoxy-6H-benzo[c]chrome...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 9-12 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13772(2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R...)
Affinity DataIC50: 11nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13766((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 11nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192684((3s,9s)-9-(2-(5-cyanopyridin-2-yloxy)-2-methylprop...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM50192797(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidaz...)
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM50192792(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144183(N-(1-Methoxy-6-thiophen-3-yl-6H-benzo[c]chromen-8-...)
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR); Value ranges from 10-12 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13768(N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]ada...)
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13762(4-({[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methyl...)
Affinity DataIC50: 12nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13769(2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[...)
Affinity DataIC50: 13nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192686(4-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

LigandPNGBDBM13767((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 14nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192798(N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13758((1R,3R,4S,7S)-4-[2-(3-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 15nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13762(4-({[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methyl...)
Affinity DataIC50: 15nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM50192673(2-(4-chlorophenoxy)-N-(1-hydroxy-2-oxatricyclo[3.3...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

LigandPNGBDBM13764((1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropa...)
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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