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TargetCystic fibrosis transmembrane conductance regulator(Human)
Abbvie S.á.R.L.

US Patent
LigandPNGBDBM300429(US10130622, Example 00008)
Affinity DataKd:  9.66E+3nMAssay Description:To measure the direct binding of small molecules with CFTR, the interaction between small molecules and membrane fragments derived from HEK293 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Abbvie S.á.R.L.

US Patent
LigandPNGBDBM300428(BDBM300430 | US10130622, Example 00007)
Affinity DataKd:  20.2nMAssay Description:To measure the direct binding of small molecules with CFTR, the interaction between small molecules and membrane fragments derived from HEK293 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM28699(2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...)
Affinity DataEC50:  5.50E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28700(alpha-1081 | procetofenic acid | Fenofibrate | CHE...)
Affinity DataEC50:  3.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28701(Cedur | 2-(4-{2-[(4-chlorophenyl)formamido]ethyl}p...)
Affinity DataEC50:  5.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28661(GW501516 | CHEMBL38943 | 2-{2-methyl-4-[({4-methyl...)
Affinity DataEC50:  1.89E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM28702(2-[2-methyl-4-(2-{4-methyl-2-[4-(trifluoromethyl)p...)
Affinity DataEC50:  2.00E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28703(2-methyl-2-[4-(2-{4-methyl-2-[4-(trifluoromethyl)p...)
Affinity DataEC50:  210nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28704(2-methyl-2-[4-({4-methyl-2-[4-(trifluoromethyl)phe...)
Affinity DataEC50:  9.50E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28705(2-methyl-2-(4-{[({4-methyl-2-[4-(trifluoromethyl)p...)
Affinity DataEC50:  70nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28706(CHEMBL219586 | 2-methyl-2-{4-[({4-methyl-2-[4-(tri...)
Affinity DataEC50:  4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM28707(2-methyl-2-{4-[(N-methyl{4-methyl-2-[4-(trifluorom...)
Affinity DataEC50:  240nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28708(2-methyl-2-{4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  1.32E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28709(2-methyl-2-{4-[2-({4-methyl-2-[4-(trifluoromethyl)...)
Affinity DataEC50:  110nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28710(CHEMBL221074 | 2-[4-({[2-(4-tert-butylphenyl)-4-me...)
Affinity DataEC50:  5nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM28711(2-methyl-2-{4-[({4-methyl-2-[4-(trifluoromethoxy)p...)
Affinity DataEC50:  4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28712(2-[4-({[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-...)
Affinity DataEC50:  10nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28713(2-methyl-2-[4-({[4-methyl-2-(4-nitrophenyl)-1,3-th...)
Affinity DataEC50:  30nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28714(2-[4-({[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5...)
Affinity DataEC50:  10nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28715(2-[4-({[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-...)
Affinity DataEC50:  40nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28716(2-methyl-2-(4-{[(4-methyl-2-phenyl-1,3-thiazol-5-y...)
Affinity DataEC50:  120nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28717(2-methyl-2-{4-[({4-methyl-2-[3-(trifluoromethyl)ph...)
Affinity DataEC50:  4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28718(2-methyl-2-{4-[({4-methyl-2-[2-(trifluoromethyl)ph...)
Affinity DataEC50:  465nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28719(2-[4-({[2-(4-aminophenyl)-4-methyl-1,3-thiazol-5-y...)
Affinity DataEC50:  5.64E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28720(2-{4-[({2-[4-(methanesulfonyloxy)phenyl]-4-methyl-...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28721(2-[4-({[2-(4-hydroxyphenyl)-4-methyl-1,3-thiazol-5...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28722(2-methyl-2-{4-[({5-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  1.89E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28723(2-methyl-2-[4-({[4-(trifluoromethyl)-2-[4-(trifluo...)
Affinity DataEC50:  4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28661(GW501516 | CHEMBL38943 | 2-{2-methyl-4-[({4-methyl...)
Affinity DataEC50:  1nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM28702(2-[2-methyl-4-(2-{4-methyl-2-[4-(trifluoromethyl)p...)
Affinity DataEC50:  4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28703(2-methyl-2-[4-(2-{4-methyl-2-[4-(trifluoromethyl)p...)
Affinity DataEC50:  20nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28704(2-methyl-2-[4-({4-methyl-2-[4-(trifluoromethyl)phe...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28705(2-methyl-2-(4-{[({4-methyl-2-[4-(trifluoromethyl)p...)
Affinity DataEC50:  4.05E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28706(CHEMBL219586 | 2-methyl-2-{4-[({4-methyl-2-[4-(tri...)
Affinity DataEC50:  2.83E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM28707(2-methyl-2-{4-[(N-methyl{4-methyl-2-[4-(trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28708(2-methyl-2-{4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  6.26E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28709(2-methyl-2-{4-[2-({4-methyl-2-[4-(trifluoromethyl)...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28710(CHEMBL221074 | 2-[4-({[2-(4-tert-butylphenyl)-4-me...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM28711(2-methyl-2-{4-[({4-methyl-2-[4-(trifluoromethoxy)p...)
Affinity DataEC50:  4.60E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28712(2-[4-({[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-...)
Affinity DataEC50:  5.40E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28713(2-methyl-2-[4-({[4-methyl-2-(4-nitrophenyl)-1,3-th...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28714(2-[4-({[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28715(2-[4-({[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28716(2-methyl-2-(4-{[(4-methyl-2-phenyl-1,3-thiazol-5-y...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28717(2-methyl-2-{4-[({4-methyl-2-[3-(trifluoromethyl)ph...)
Affinity DataEC50: >2.50E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28718(2-methyl-2-{4-[({4-methyl-2-[2-(trifluoromethyl)ph...)
Affinity DataEC50:  808nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28719(2-[4-({[2-(4-aminophenyl)-4-methyl-1,3-thiazol-5-y...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28720(2-{4-[({2-[4-(methanesulfonyloxy)phenyl]-4-methyl-...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28721(2-[4-({[2-(4-hydroxyphenyl)-4-methyl-1,3-thiazol-5...)
Affinity DataEC50: >1.00E+4nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM28722(2-methyl-2-{4-[({5-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataEC50:  660nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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