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TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241079(CHEMBL4072936)
Affinity DataEC50:  340nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241080(CHEMBL4093640)
Affinity DataEC50:  170nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241082(CHEMBL4098909)
Affinity DataEC50:  2.90E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241086(CHEMBL4071919)
Affinity DataEC50:  260nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241088(CHEMBL4063293)
Affinity DataEC50:  120nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241104(CHEMBL4091019)
Affinity DataEC50:  5.30E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241109(CHEMBL4076701)
Affinity DataEC50:  100nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241110(CHEMBL4081891)
Affinity DataEC50:  3.80E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataEC50:  1.47E+4nMAssay Description:Transactivation of human GAL4-fused PPARgamma ligand binding domain expressed in HEL293T cells after 12 to 14 hrs by dual-glo luciferase reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241117(CHEMBL4095466)
Affinity DataEC50:  670nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241118(CHEMBL4068899)
Affinity DataEC50:  440nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241120(CHEMBL4104364)
Affinity DataEC50:  1.36E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241122(CHEMBL4094234)
Affinity DataEC50:  370nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241123(CHEMBL4067723)
Affinity DataEC50:  1.20E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241124(CHEMBL4078618)
Affinity DataEC50:  1.70E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241130(CHEMBL4096637)
Affinity DataEC50:  6.40E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241131(CHEMBL4072573)
Affinity DataEC50:  350nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241133(CHEMBL4079796)
Affinity DataEC50:  160nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241134(CHEMBL4104050)
Affinity DataEC50:  140nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241135(CHEMBL4060350)
Affinity DataEC50:  7.80nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241136(CHEMBL4088582)
Affinity DataEC50:  7.50E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241138(CHEMBL4069036)
Affinity DataEC50:  76nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10894(4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamid...)
Affinity DataEC50:  1.40E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241144(CHEMBL1300445)
Affinity DataEC50:  150nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241145(CHEMBL4100178)
Affinity DataEC50:  160nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241152(CHEMBL4073326)
Affinity DataEC50:  170nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241158(CHEMBL4064739)
Affinity DataEC50:  100nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241147(CHEMBL4084686)
Affinity DataEC50:  1.30E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241149(CHEMBL4102626)
Affinity DataEC50:  3.80E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241150(CHEMBL4094881)
Affinity DataEC50:  970nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241151(CHEMBL4087681)
Affinity DataEC50:  14nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241160(CHEMBL4095371)
Affinity DataEC50:  46nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241172(CHEMBL4097715)
Affinity DataEC50:  320nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241173(CHEMBL4084092)
Affinity DataEC50:  370nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241164(CHEMBL4088942)
Affinity DataEC50:  3.80E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241174(CHEMBL4093296)
Affinity DataEC50:  730nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241175(CHEMBL4087682)
Affinity DataEC50:  8.80nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241168(CHEMBL4061980)
Affinity DataEC50:  44nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241146(CHEMBL4092436)
Affinity DataEC50:  160nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241176(CHEMBL4074393)
Affinity DataEC50:  0.400nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataEC50:  20nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataKd:  130nMAssay Description:Binding affinity to FXR ligand binding domain (unknown origin) isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50301375(L-thyroxine | 3,3',5,5'-tetraiodo-L-thyronine | 3,...)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  5.80E+3nMAssay Description:Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50103763(CHEBI:11684 | Reverse Tri-Iodothyronine | REVERSE ...)
Affinity DataEC50:  3.80E+3nMAssay Description:Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM398043(US10322118, Entry 1)
Affinity DataEC50:  100nMAssay Description:Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM18862(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)
Affinity DataEC50:  370nMAssay Description:Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50301375(L-thyroxine | 3,3',5,5'-tetraiodo-L-thyronine | 3,...)
Affinity DataKd:  400nMAssay Description:Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  710nMAssay Description:Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50103763(CHEBI:11684 | Reverse Tri-Iodothyronine | REVERSE ...)
Affinity DataKd:  630nMAssay Description:Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
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