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TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0426nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247744(CHEMBL504725 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  0.0730nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247741(CHEMBL503101 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  0.228nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247749(CHEMBL510583 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50385670(CHEMBL2042399)
Affinity DataKi:  0.490nMAssay Description:Antagonist activity at human TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20286(5-I-RTX | 5-iodoresiniferatoxin | [(1R,2R,6R,10S,1...)
Affinity DataKi:  0.610nM ΔG°:  -54.7kJ/mole EC50:  12.2nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247742(CHEMBL509154 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247748(CHEMBL510228 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  0.890nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247751(CHEMBL449201 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  0.980nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20314((2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-c...)
Affinity DataKi:  1.83nM ΔG°:  -51.9kJ/mole EC50:  5.20nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017594(CHEMBL3288626)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]RTX from rat TRPV1 after 60 mins by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247745(CHEMBL455555 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247750(CHEMBL455155 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  2.69nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330657(2-(4-tert-Butylbenzyl)-3-[2-(4-hydroxy-3-iodo-5-me...)
Affinity DataKi:  2.80nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247746(CHEMBL502769 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20311((2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-c...)
Affinity DataKi:  3.29nM ΔG°:  -50.4kJ/mole EC50:  12.1nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20330(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Affinity DataKi:  3.40nMAssay Description:Antagonist activity for rat TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20330(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Affinity DataKi:  3.40nMAssay Description:Antagonist activity towards rat TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330677(2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3-bromo-5-met...)
Affinity DataKi:  3.40nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247747(CHEMBL509331 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  3.53nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20291(2-[(4-tert-butylphenyl)methyl]-3-[2-(3-chloro-4-me...)
Affinity DataKi:  3.60nM ΔG°:  -50.1kJ/mole EC50:  12.3nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330680(2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3,5-dichlorop...)
Affinity DataKi:  3.96nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330676(2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3-chloro-5-me...)
Affinity DataKi:  4.09nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20313((2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-f...)
Affinity DataKi:  4.12nM ΔG°:  -49.8kJ/mole EC50:  0.580nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50385670(CHEMBL2042399)
Affinity DataKi:  4.16nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330672(2-(4-tert-Butylbenzyl)-3-[2-(3,5-dichloro-4-hydrox...)
Affinity DataKi:  4.26nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330681(2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3,5-dibromoph...)
Affinity DataKi:  4.30nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50385656(CHEMBL2042264)
Affinity DataKi:  5.10nMAssay Description:Antagonist activity at human TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50204623(CHEMBL223747 | [2-(hydroxymethyl)-4-(methylethylid...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]PDBu from PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50204626((2-(hydroxymethyl)-5-oxo-4-(propan-2-ylidene)-tetr...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]PDBu from PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017592(CHEMBL3288624)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]RTX from rat TRPV1 after 60 mins by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20310((2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-f...)
Affinity DataKi:  6.26nM ΔG°:  -48.7kJ/mole EC50:  10.9nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50196343(2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]RTX from rat TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017581(CHEMBL3288631)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]RTX from rat TRPV1 after 60 mins by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247743(CHEMBL504206 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  6.81nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017592(CHEMBL3288624)
Affinity DataKi:  6.90nMAssay Description:Antagonist activity at rat TRPV1 heterologously expressed in CHO cells assessed as inhibition of capsaicin-induced [45Ca2+] uptake by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50017593(CHEMBL3288625)
Affinity DataKi:  7.10nMAssay Description:Antagonist activity at rat TRPV1 heterologously expressed in CHO cells assessed as inhibition of capsaicin-induced [45Ca2+] uptake by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50385658(CHEMBL2042266)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]RTX from rat TRPV1 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50385671(CHEMBL2042384)
Affinity DataKi:  7.40nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50385656(CHEMBL2042264)
Affinity DataKi:  7.60nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20293(2-[(3,4-dimethylphenyl)methyl]-3-({[(3-fluoro-4-me...)
Affinity DataKi:  7.80nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of 45Ca2+ uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50362800(CHEMBL1940382)
Affinity DataKi:  8nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50385670(CHEMBL2042399)
Affinity DataKi:  8.30nMAssay Description:Antagonist activity at human TRPV1 receptor expressed in CHO cells assessed as decrease in pH-induced intracellular 45Ca2+ uptake after 1 hr by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50247752(CHEMBL462654 | [(1R,2R,6R,10S,11R,15S,17R)-13-benz...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330656(2-(4-tert-Butylbenzyl)-3-[2-(3-bromo-4-hydroxy-5-m...)
Affinity DataKi:  8.77nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20321(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Affinity DataKi:  9.16nMAssay Description:Antagonist activity for rat TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20321(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Affinity DataKi:  9.16nMAssay Description:Antagonist activity towards rat TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20321(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Affinity DataKi:  9.20nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330672(2-(4-tert-Butylbenzyl)-3-[2-(3,5-dichloro-4-hydrox...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]RTX from rat TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50330656(2-(4-tert-Butylbenzyl)-3-[2-(3-bromo-4-hydroxy-5-m...)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]RTX from rat TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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