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TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231998(CHEMBL4085835)
Affinity DataIC50: 28nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of A23187-induced product formation using arachidonic acid as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078888(CHEMBL3416359)
Affinity DataIC50: 29nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231991(CHEMBL4093584)
Affinity DataIC50: 30nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of A23187-induced product formation using arachidonic acid as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078886(CHEMBL3416361)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078890(CHEMBL3416357)
Affinity DataIC50: 40nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078887(CHEMBL3416360)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50: 60nMAssay Description:Inhibition of human 5-LOX by cell free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078889(CHEMBL3416358)
Affinity DataIC50: 60nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231998(CHEMBL4085835)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078890(CHEMBL3416357)
Affinity DataIC50: 70nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078887(CHEMBL3416360)
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078889(CHEMBL3416358)
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078886(CHEMBL3416361)
Affinity DataIC50: 90nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231999(CHEMBL4103758)
Affinity DataIC50: 90nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of A23187-induced product formation using arachidonic acid as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078889(CHEMBL3416358)
Affinity DataIC50: 100nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078883(CHEMBL3416365)
Affinity DataIC50: 100nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231991(CHEMBL4093584)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078887(CHEMBL3416360)
Affinity DataIC50: 120nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078886(CHEMBL3416361)
Affinity DataIC50: 120nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50232002(CHEMBL4095644)
Affinity DataIC50: 120nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of A23187-induced product formation using arachidonic acid as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078888(CHEMBL3416359)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078890(CHEMBL3416357)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078883(CHEMBL3416365)
Affinity DataIC50: 150nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078888(CHEMBL3416359)
Affinity DataIC50: 150nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231996(CHEMBL4069339)
Affinity DataIC50: 150nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of A23187-induced product formation using arachidonic acid as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078847(CHEMBL3416165)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078849(CHEMBL3416164)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142747(CHEMBL3758589)
Affinity DataIC50: 170nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142706(CHEMBL3759622)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078851(CHEMBL3416163)
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142751(CHEMBL3759086)
Affinity DataIC50: 182nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078881(CHEMBL3416166)
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142706(CHEMBL3759622)
Affinity DataIC50: 190nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078865(CHEMBL2296071)
Affinity DataIC50: 200nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142688(CHEMBL3759494)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231993(CHEMBL4088278)
Affinity DataIC50: 200nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of A23187-induced product formation using arachidonic acid as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078868(CHEMBL3416349)
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetMacrophage-expressed gene 1 protein(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50: 210nMAssay Description:Inhibition of human mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetMacrophage-expressed gene 1 protein(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50: 210nMAssay Description:Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 220nMAssay Description:Inhibition of 5-LO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078848(CHEBI:8779 | Rapanone)
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142689(CHEMBL3759314)
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231996(CHEMBL4069339)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50016516(CHEMBL3260691)
Affinity DataIC50: 230nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production from arachidonic acid preincubated for 15 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078867(CHEMBL3416348)
Affinity DataIC50: 230nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50078882(CHEMBL462998)
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142748(CHEMBL3758897)
Affinity DataIC50: 237nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142689(CHEMBL3759314)
Affinity DataIC50: 240nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50231999(CHEMBL4103758)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
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