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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in human K177 cell membrane incubated for 75 mins by liquid scintillation spectro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in human K177 cell membrane incubated for 75 mins by liquid scintillation spectro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548705(CHEMBL4740159)
Affinity DataKi:  0.320nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]nicotine from rat alpha4beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi: <1nMAssay Description:Agonist activity at alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in human K177 cell membrane incubated for 75 mins by liquid scintillation spectro...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548704(CHEMBL4791046)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548703(CHEMBL4793576)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  2nMAssay Description:Displacement of 3H-cytisine from Sprague-Dawley rat brain alpha4beta2 nAChR by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in K28 cell membraneMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity to rat alpha4beta2 nAChRMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  5.60nMAssay Description:Displacement of 3H-cytisine from rat brain alpha4beta2 nAChR by radioligand binding assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat frontal cortex membrane by scintillation counting methodMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-1(Bovine)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548713(1-Methyl-Nicotinic Acid Anion(Trigonelline) | CHEB...)
Affinity DataKi:  13nMAssay Description:Competitive inhibition of bovine GABAA alpha1beta1 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of California Riverside

Curated by ChEMBL
LigandPNGBDBM50587038(CHEMBL5090086)
Affinity DataKi:  17nMAssay Description:Inhibition of human Mcl-1 assessed as inhibition constant by DELFIA displacement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548708(CHEMBL4779424)
Affinity DataKi:  26nMAssay Description:Inhbition of [3H] nicotine binding to rat brain alpha4beta2 nAChRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109773(US8609708, 74 Anabaseine)
Affinity DataKi:  32nMAssay Description:Binding affinity to rat alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of California Riverside

Curated by ChEMBL
LigandPNGBDBM50587037(CHEMBL5082279)
Affinity DataKi:  37nMAssay Description:Inhibition of human Mcl-1 assessed as inhibition constant by DELFIA displacement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109773(US8609708, 74 Anabaseine)
Affinity DataKi:  58nMAssay Description:Binding affinity to rat alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548702(CHEMBL4798114)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548687(CHEMBL4781983)
Affinity DataKi:  108nMAssay Description:Displacement of [3H]-cytisine from rat brain membrane alpha4beta2 nAChRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548711(CHEMBL4761823)
Affinity DataKi:  119nMAssay Description:Displacement of 3H-cytisine from Sprague-Dawley rat brain alpha4beta2 nAChR by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548686(CHEMBL4798987)
Affinity DataKi:  136nMAssay Description:Displacement of [3H]-cytisine from rat brain membrane alpha4beta2 nAChRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109762(US8609708, 50 Anatabine)
Affinity DataKi:  249nMAssay Description:Displacement of 3H-cytisine from Sprague-Dawley rat brain alpha4beta2 nAChR by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109767(US10667515, Compound (S)-anabasine | US8609708, 59...)
Affinity DataKi:  390nMAssay Description:Displacement of 125I-alpha-bungarotoxin from rat brain alpha7 nAChR by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  400nMAssay Description:Binding affinity to rat alpha7 nAChRMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  530nMAssay Description:Binding affinity to alpha3beta4 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548712(CHEMBL1496898)
Affinity DataKi:  910nMAssay Description:Displacement of 3H-cytisine from rat brain alpha4beta2 nAChR by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM109767(US10667515, Compound (S)-anabasine | US8609708, 59...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of 3H-cytisine from rat brain alpha4beta2 nAChR by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548709(CHEMBL4759978)
Affinity DataKi:  1.18E+3nMAssay Description:Inhbition of [3H] nicotine binding to rat brain alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [3H]MLA from rat alpha7 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in K28 cell membraneMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50370573(COTININE | US10667515, Compound (S)-cotinine | US8...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat frontal cortex membrane by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548712(CHEMBL1496898)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of 125I-alpha-bungarotoxin from rat brain alpha7 nAChR by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  6.29E+3nMAssay Description:Binding affinity to alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548706(CHEMBL4752214)
Affinity DataKi:  1.40E+4nMAssay Description:Displacement of [3H]nicotine from rat alpha4beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548707(CHEMBL4792387)
Affinity DataKi:  5.10E+4nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's colorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548706(CHEMBL4752214)
Affinity DataKi:  2.60E+5nMAssay Description:Displacement of [3H]MLA from rat alpha7 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548707(CHEMBL4792387)
Affinity DataKi:  4.40E+5nMAssay Description:Inhibition of horse serum BuChE by Ellman's colorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50548705(CHEMBL4740159)
Affinity DataIC50:  0.960nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Human)
University of Massachusetts-Boston

Curated by ChEMBL
LigandPNGBDBM50458963(CHEMBL4209902)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant PLK1 by Z-Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1a(2019-nCoV)
Gilead Sciences, Inc.

US Patent
LigandPNGBDBM667004(US20240116946, Example 1038)
Affinity DataIC50:  1.28nMAssay Description:This biochemical assay measured small molecule inhibitor IC50 values against recombinant SARS-CoV-2 Main protease (Mpro). Compounds from 100 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Gilead Sciences, Inc.

US Patent
LigandPNGBDBM666947(US20240116946, Example 981)
Affinity DataIC50:  1.38nMAssay Description:This biochemical assay measured small molecule inhibitor IC50 values against recombinant SARS-CoV-2 Main protease (Mpro). Compounds from 100 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Gilead Sciences, Inc.

US Patent
LigandPNGBDBM667002(1037 | US20240116946, Example 1036 | US20240116946...)
Affinity DataIC50:  1.42nMAssay Description:This biochemical assay measured small molecule inhibitor IC50 values against recombinant SARS-CoV-2 Main protease (Mpro). Compounds from 100 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Gilead Sciences, Inc.

US Patent
LigandPNGBDBM666978(1013 | US20240116946, Example 1012 | US20240116946...)
Affinity DataIC50:  1.42nMAssay Description:This biochemical assay measured small molecule inhibitor IC50 values against recombinant SARS-CoV-2 Main protease (Mpro). Compounds from 100 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Gilead Sciences, Inc.

US Patent
LigandPNGBDBM666887(US20240116946, Example 921)
Affinity DataIC50:  1.42nMAssay Description:This biochemical assay measured small molecule inhibitor IC50 values against recombinant SARS-CoV-2 Main protease (Mpro). Compounds from 100 μM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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