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TargetEstrogen receptor beta(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175410(4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol...)
Affinity DataEC50:  40.8nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataEC50:  1.09nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.0100nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  0.140nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175410(4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol...)
Affinity DataEC50: >1.00E+3nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175415(4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)p...)
Affinity DataEC50:  6.70nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175415(4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)p...)
Affinity DataEC50:  243nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataEC50:  38.5nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232526(5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-dia...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237216(CHEMBL4080254)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237201(CHEMBL4082618)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237200(CHEMBL4072132)
Affinity DataIC50: 0.0690nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM36530(D157493)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237203(CHEMBL250072)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237199(CHEMBL4077061)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237205(CHEMBL398675)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237209(CHEMBL4062544)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237211(CHEMBL4061457)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237210(CHEMBL399673)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM36534(D156095)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146201(6-Phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5...)
Affinity DataIC50: 0.5nMAssay Description:In vitro concentration required to inhibit [3H]estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 0.75nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237217(CHEMBL342595)
Affinity DataIC50: 1nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataIC50: 1.12nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 1.18nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146201(6-Phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5...)
Affinity DataIC50: 1.20nMAssay Description:In vitro concentration required to inhibit [3H]estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19459(Prunetol | Genisteol | CHEMBL44 | US8552057, 2 | c...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237202(CHEMBL4103454)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013412(CHEMBL3263752)
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to mineralocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237198(CHEMBL4068466)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013430(CHEMBL3263768)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237218(CHEMBL4072481)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175413(4-(4-phenyl-5-(trifluoromethyl)isoxazol-3-yl)pheno...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013422(CHEMBL3263760)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013428(CHEMBL3263766)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232566(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398061(CHEMBL2181928)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at rat GAL4-DBD fused MR ligand binding domain transfected in human Huh7 cells co-expressing GAL4-RE-Luc assessed as reduction in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013426(CHEMBL3263764)
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013424(CHEMBL3263762)
Affinity DataIC50: 3.70nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandPNGBDBM50134771(CHEMBL3754515)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013429(CHEMBL3263767)
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013425(CHEMBL3263763)
Affinity DataIC50: 4.30nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013419(CHEMBL3263757)
Affinity DataIC50: 4.40nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50013412(CHEMBL3263752)
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146206(2-Benzyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1...)
Affinity DataIC50: 4.70nMAssay Description:In vitro concentration required to inhibit [3H]estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146200((E)-3-[4-(6-Hydroxy-1-phenyl-3,4-dihydro-1H-isoqui...)
Affinity DataIC50: 4.80nMAssay Description:In vitro concentration required to inhibit [3H]estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146223(2-Benzenesulfonyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-...)
Affinity DataIC50: 5.20nMAssay Description:In vitro concentration required to inhibit [3H]estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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