Compile Data Set for Download or QSAR
Found 564 with Last Name = 'pike' and Initial = 'vw'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi:  0.0360nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.0726nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.0726nMAssay Description:Displacement of [3H]PK11195 from rat PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400876(CHEMBL2204347)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229593(CHEMBL253596 | N-acetyl-N-(2-methoxycarbonylbenzyl...)
Affinity DataKi:  0.0978nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400875(CHEMBL2204353)
Affinity DataKi:  0.101nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400874(CHEMBL2086410)
Affinity DataKi:  0.106nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400873(CHEMBL2088029)
Affinity DataKi:  0.137nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400872(CHEMBL2088033)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50255877(CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenz...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]PK11195 from rat PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327858((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327865((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(2-fluoroe...)
Affinity DataKi:  0.215nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400871(CHEMBL2088030)
Affinity DataKi:  0.231nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.242nMAssay Description:Binding affinity to PBR in human mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.242nMAssay Description:Displacement of [3H]PK11195 from human PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336827(3-[(2-Aminothiazol)-4-ethynyl]-5-fluorobenzonitril...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50400870(CHEMBL559569 | SB-612111)
Affinity DataKi:  0.253nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336830(3-((2-Chlorothiazol)-4-yl)ethynyl)benzonitrile | C...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335260(CHEMBL1651226 | N,N-dihexyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.299nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335259(CHEMBL1651225 | N,N-dibutyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253862((-)-3-(4-Chlorophenyl)-N'-[(4-iodophenyl)sulfonyl]...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  0.334nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327864((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(fluoromet...)
Affinity DataKi:  0.334nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM22038(2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50383117(CHEMBL2031737)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336831(3-((2-Chlorothiazol)-4-yl)ethynyl)-5-fluorobenzoni...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327859((1-Butylpiperidin-4-yl)methyl 8-amino-7-cyano-2,3-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50060095(2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253826((-)-3-(4-Chlorophenyl)-N'-[(4-cyanophenyl)sulfonyl...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  0.577nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229594(CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...)
Affinity DataKi:  0.680nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229596(1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl...)
Affinity DataKi:  0.730nMAssay Description:Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327861((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...)
Affinity DataKi:  0.738nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]Pentazocine from rat sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336826(3-[(2-Aminothiazol)-4-ethynyl]benzonitrile | CHEMB...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327862((1-Propylpiperidin-4-yl)methyl 4-Amino-3-methoxybe...)
Affinity DataKi:  0.901nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336835(3-((2-Bromothiazol)-4-ethynyl)-5-fluorobenzonitril...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50255877(CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenz...)
Affinity DataKi:  0.997nMAssay Description:Displacement of [3H]PK11195 from human PBR receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]HEAT from adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Institutet

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataKi:  1nMAssay Description:Binding affinity at NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50383118(CHEMBL2031738)
Affinity DataKi:  1nMAssay Description:Binding affinity to rat H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat kidney membranesMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50335268(2-(2-(4-fluorophenyl)-1-methyl-1H-indol-3-yl)-N,N-...)
Affinity DataKi:  1.07nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]N-methylspiperone from dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50336839(3-((2-Iodothiazol)-4-ethynyl)-5-fluorobenzonitrile...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50229593(CHEMBL253596 | N-acetyl-N-(2-methoxycarbonylbenzyl...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to PBR in human mitochondrial tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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