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TargetSigma non-opioid intracellular receptor 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440737(CHEMBL2431120)
Affinity DataKi:  410nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440737(CHEMBL2431120)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to 5-HT3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440737(CHEMBL2431120)
Affinity DataKi:  1.42E+3nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440737(CHEMBL2431120)
Affinity DataKi:  2.54E+3nMAssay Description:Binding affinity to PBR receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntestinal-type alkaline phosphatase(Mouse)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50447413(CHEMBL3115157)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of mouse duodenal-specific FLAG-tagged IAP expressed in African green monkey COS1 cells using p-nitrophenyl phosphate as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50248035((2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxy...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of NTS1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50248035((2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxy...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of MOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50248035((2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxy...)
Affinity DataKi:  5.20E+3nMAssay Description:Inhibition of DOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50444943(CHEMBL3099773)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50444943(CHEMBL3099773)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of NTS1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50248035((2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxy...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440738(CHEMBL2431105)
Affinity DataIC50:  0.240nMAssay Description:Displacement of [125I]-neurotensin from NTR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440738(CHEMBL2431105)
Affinity DataIC50:  0.240nMAssay Description:Displacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM85050(CAS_184162-64-9 | SR 142948A | SR142948 | SR142948...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at NTR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332633(3-(4-fluorophenyl)-1-(2-{[4-(trifluoromethyl)pheny...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332632(1-{2-[(4-chlorophenyl)carbonyl]-2,7-diazaspiro[3.5...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332640(1-{7-[(4-bromophenyl)carbonyl]-2,7-diazaspiro[3.5]...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332641(3-(4-fluorophenyl)-1-(7-{[4-(trifluoromethyl)pheny...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332645(5-chloroindol-2-yl 9-{[3-fluoro-4-(trifluoromethyl...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332646(5-bromoindol-2-yl 7-{[4-(trifluoromethyl)phenyl]ca...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332648((2E)-3-(4-bromophenyl)-1-{2-[(4-chlorophenyl)carbo...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332546((2E)-1-{7-[(2E)-3-(4-bromophenyl)prop-2-enoyl]-2,7...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332547((2E)-3-(4-bromophenyl)-1-{7-[(3-bromophenyl)carbon...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332549(5-chloroindol-2-yl 2-[(3-fluorophenyl)methyl]-2,7-...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332550(5-chloroindol-2-yl 2-[(4-fluorophenyl)carbonyl]-2,...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332551((2E)-3-(4-bromophenyl)-1-{2-[(4-chlorophenyl)methy...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332552((2E)-3-(4-bromophenyl)-1-[2-(phenylcarbonyl)-2,7-d...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332553((2E)-3-(4-bromophenyl)-1-{2-[(4-fluorophenyl)methy...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332554((2E)-1-{2-[(3,4-dimethoxyphenyl)carbonyl]-2,7-diaz...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332555((2E)-1-{2-[(3,5-dichlorophenyl)carbonyl]-2,7-diaza...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332556((2E)-1-{2-[(2,6-dichlorophenyl)methyl]-2,7-diazasp...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332557((2E)-3-(4-bromophenyl)-1-{2-[(3-methylphenyl)carbo...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332562(5-chloroindol-2-yl 2-[(4-fluorophenyl)methyl]-2,7-...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332563(5-chloroindol-2-yl 7-{[3-fluoro-4-(trifluoromethyl...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332564((2E)-3-(4-bromophenyl)-1-{7-[(4-chlorophenyl)carbo...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332565((2E)-3-(4-bromophenyl)-1-{7-[(4-fluorophenyl)carbo...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332566((2E)-3-(4-bromophenyl)-1-(7-{[4-(trifluoromethyl)p...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332567((2E)-3-(4-bromophenyl)-1-(7-{[4-fluoro-3-(trifluor...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332573((2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-fluorophenyl)...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332574((2E)-3-(3,4-dichlorophenyl)-1-{7-[(4-chlorophenyl)...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332575((2E)-3-(3,4-dichlorophenyl)-1-(7-{[4-(trifluoromet...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332580((2E)-1-{2-[(2E)-3-(3,4-dichlorophenyl)prop-2-enoyl...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332584(5-chloroindol-2-yl 7-{[4-(trifluoromethyl)phenyl]c...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332585(5-chloroindol-2-yl 7-[(4-chlorophenyl)carbonyl]-2,...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332588(4-({2-[(2E)-3-(4-bromophenyl)prop-2-enoyl]-2,7-dia...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332589((2E)-1-{7-[(3,5-difluorophenyl)carbonyl]-2,7-diaza...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332590((2E)-3-(4-bromophenyl)-1-(7-{[4-fluoro-2-(trifluor...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332591(5-bromoindol-2-yl 7-[(4-bromophenyl)carbonyl]-2,7-...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332593(5-bromoindol-2-yl 7-{[4-fluoro-2-(trifluoromethyl)...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetG-protein coupled receptor 183(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM332596((2E)-1-{7-[(4-aminophenyl)carbonyl]-2,7-diazaspiro...)
Affinity DataIC50: <5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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