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TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406539(CHEMBL4175573)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406539(CHEMBL4175573)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406688(CHEMBL4166620)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50406688(CHEMBL4166620)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in rat GH4C1 cells assessed as inward channel current amplitude at -70 mV holding potential by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515335(CHEMBL4532589)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515320(CHEMBL4441630)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515333(CHEMBL4460815)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515333(CHEMBL4460815)
Affinity DataEC50:  520nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
Istituto Di Chimica Biomolecolare

Curated by ChEMBL
LigandPNGBDBM50515335(CHEMBL4532589)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334652(3-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)p...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 9.70nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO cell membranes assessed as reduction in GTPgammaS binding after 30 mins by microbeta count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334653(5-((1H-benzo[d]imidazol-2-yl)methylthio)-2-methyl-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50334665(9-Chloro-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imida...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334670(2,9-Dimethyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50232938(CHEMBL4088509)
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 EBNA cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50232941(CHEMBL4084087)
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 EBNA cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50152112(CHEMBL3780792)
Affinity DataIC50: 27nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptors expressed in human Chem4 cell membrane incubated for 30 mins by [35S]GTPgammaS binding ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334667(8-Methoxy-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imid...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50232933(CHEMBL4094388)
Affinity DataIC50: 35nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 EBNA cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334666(7-Methoxy-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imid...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50094751(3-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-8-(1H-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in Sprague-Dawley rat striatum synaptosomeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049925(CHEMBL3317682)
Affinity DataIC50: 40nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049931(CHEMBL3317688)
Affinity DataIC50: 40nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049930(CHEMBL3317687)
Affinity DataIC50: 42nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334654(2-Methyl-5-((1-methyl-4-phenyl-1H-imidazol-2-ylthi...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334662(2-Methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334664(8-Chloro-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imida...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334662(2-Methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50152111(CHEMBL3781178)
Affinity DataIC50: 51nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptors expressed in human Chem4 cell membrane incubated for 30 mins by [35S]GTPgammaS binding ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50232930(CHEMBL4067246)
Affinity DataIC50: 51nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 EBNA cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334663(7-Chloro-2-methyl-5-(2-(1-methyl-4-phenyl-1H-imida...)
Affinity DataIC50: 52nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50049932(CHEMBL3317689)
Affinity DataIC50: 55nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50232936(CHEMBL4071738)
Affinity DataIC50: 55nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 EBNA cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334655(7-Chloro-2-methyl-5-((1-methyl-4-phenyl-1H-imidazo...)
Affinity DataIC50: 73nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334661(2,9-Dimethyl-5-((1-methyl-4-phenyl-1H-imidazol-2-y...)
Affinity DataIC50: 76nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334669(2,7-Dimethyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2...)
Affinity DataIC50: 78nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50152116(CHEMBL3781131)
Affinity DataIC50: 80nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptors expressed in human Chem4 cell membrane incubated for 30 mins by [35S]GTPgammaS binding ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334658(7-Methoxy-2-methyl-5-((1-methyl-4-phenyl-1H-imidaz...)
Affinity DataIC50: 83nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50200170(SR-144528 | 5-(4-chloro-3-methylphenyl)-1-(4-methy...)
Affinity DataIC50: 96nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 EBNA cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334659(8-Methoxy-2-methyl-5-((1-methyl-4-phenyl-1H-imidaz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334657(9-Chloro-2-methyl-5-((1-methyl-4-phenyl-1H-imidazo...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334656(8-Chloro-2-methyl-5-((1-methyl-4-phenyl-1H-imidazo...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50334660(2,7-Dimethyl-5-((1-methyl-4-phenyl-1H-imidazol-2-y...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50614138(CHEMBL5283494)
Affinity DataIC50: 170nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50049926(CHEMBL3317683)
Affinity DataIC50: 170nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50116907(CHEMBL3613097)
Affinity DataIC50: 171nMAssay Description:Antagonist/inverse agonist activity at human CB2 receptor transfected in Chem4 cell membranes after 30 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Sassari

Curated by ChEMBL
LigandPNGBDBM50454100(CHEMBL4206866)
Affinity DataIC50: 182nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO cell membranes assessed as reduction in GTPgammaS binding after 30 mins by microbeta count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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