Report error Found 2448 with Last Name = 'pio' and Initial = 'b'
Affinity DataKi: 0.200nM EC50: 5.10nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.420nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.550nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.590nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.610nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.620nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.620nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.660nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.660nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.710nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMpH: 7.4Assay Description:Relevant in vitro assays are referenced in Morrissette, et al., Bioorg. Med. Chem. Lett. 2004, 14, 4161-4164 and described in Lewis, et al. Thromb. R...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Binding affinity for human progesterone receptor; Not activeMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMpH: 7.4Assay Description:Relevant in vitro assays are referenced in Morrissette, et al., Bioorg. Med. Chem. Lett. 2004, 14, 4161-4164 and described in Lewis, et al. Thromb. R...More data for this Ligand-Target Pair
Affinity DataKi: 2.5nMpH: 7.4Assay Description:Relevant in vitro assays are referenced in Morrissette, et al., Bioorg. Med. Chem. Lett. 2004, 14, 4161-4164 and described in Lewis, et al. Thromb. R...More data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Inhibition of DHT binding to human androgen receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3nMpH: 7.5Assay Description:Thrombin receptor antagonists were screened using a modification of the thrombin receptor radioligand binding assay of Ahn et al. (Ahn et al., Mol. P...More data for this Ligand-Target Pair
Affinity DataKi: 3nMpH: 7.5Assay Description:Thrombin receptor antagonists were screened using a modification of the thrombin receptor radioligand binding assay of Ahn et al. (Ahn et al., Mol. P...More data for this Ligand-Target Pair
Affinity DataKi: 3nMpH: 7.5Assay Description:Thrombin receptor antagonists were screened using a modification of the thrombin receptor radioligand binding assay of Ahn et al. (Ahn et al., Mol. P...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute
Sandoz Research Institute
Affinity DataKi: 3.30nM IC50: 175nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute
Sandoz Research Institute
Affinity DataKi: 3.40nM ΔG°: -50.3kJ/mole IC50: 25nMpH: 6.25 T: 37°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute
Sandoz Research Institute
Affinity DataKi: 3.40nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMpH: 7.4Assay Description:Relevant in vitro assays are referenced in Morrissette, et al., Bioorg. Med. Chem. Lett. 2004, 14, 4161-4164 and described in Lewis, et al. Thromb. R...More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMpH: 7.4Assay Description:Relevant in vitro assays are referenced in Morrissette, et al., Bioorg. Med. Chem. Lett. 2004, 14, 4161-4164 and described in Lewis, et al. Thromb. R...More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMpH: 7.4Assay Description:Relevant in vitro assays are referenced in Morrissette, et al., Bioorg. Med. Chem. Lett. 2004, 14, 4161-4164 and described in Lewis, et al. Thromb. R...More data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 3.90nMpH: 7.4Assay Description:Relevant in vitro assays are referenced in Morrissette, et al., Bioorg. Med. Chem. Lett. 2004, 14, 4161-4164 and described in Lewis, et al. Thromb. R...More data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute
Sandoz Research Institute
Affinity DataKi: 4.10nM IC50: 161nMAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair