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TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 1.20nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509011(CHEMBL4538713)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509016(CHEMBL4450972)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509014(CHEMBL4557975)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16313(IDD594 | LdT | CHEMBL395347 | {2-[(4-bromo-2-fluor...)
Affinity DataIC50: 3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16485(2-{6-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Affinity DataIC50: 5nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16491(2-{7-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 6nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16482(2-{6-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 7nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16488(2-{7-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 7nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509010(CHEMBL4518246)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16483(2-{6-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16477(2-{5-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Affinity DataIC50: 8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16470(2-{2-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16493(2-{3-[2-(4,5,7-trifluoro-1,3-benzothiazol-2-yl)eth...)
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16481(2-[5-(morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benz...)
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16496(CHEMBL10413 | FR 74366 | [3-(4-bromo-2-fluorobenzy...)
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16476(2-{5-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 9nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16489(2-{7-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 9nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16464(2-{3-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Affinity DataIC50: 9nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16484(2-{6-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 10nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509012(CHEMBL4572850)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509015(CHEMBL4594157)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16473(2-{5-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 10nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509018(CHEMBL4461464)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16472(2-{4-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 11nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509017(CHEMBL4578964)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16474(2-{5-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 11nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16478(2-[5-(benzyloxy)-3-[(4,5,7-trifluoro-1,3-benzothia...)
Affinity DataIC50: 12nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16475(2-{5-bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-...)
Affinity DataIC50: 13nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 13nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16490(2-{7-bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-...)
Affinity DataIC50: 14nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16487(2-[6-(morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benz...)
Affinity DataIC50: 15nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509009(CHEMBL4530103)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16494(3-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methy...)
Affinity DataIC50: 17nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509019(CHEMBL4459462)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509003(CHEMBL4556601)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16486(2-{6-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 25nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509013(CHEMBL4434802)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16479(2-{5-phenoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Affinity DataIC50: 30nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM200221(2-(5-chloro-2-(((perbromophenyl)methyl)carbamoyl)p...)
Affinity DataIC50: 30nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16463(2-{3-[(4-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Affinity DataIC50: 34nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16461(2-(6-bromo-3-{[5-(trifluoromethyl)-1,3-benzothiazo...)
Affinity DataIC50: 52nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16480(2-{5-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50: 53nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16466(2-{3-[(7-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Affinity DataIC50: 55nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 60nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetArginase-1(Human)
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetArginase-2, mitochondrial(Human)
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
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