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TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50024101((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEEF1AKMT4-ECE2 readthrough transcript protein(Homo sapiens (Human))
Pharmaleads

LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataKi:  1.20nM IC50:  2.33nMAssay Description:Inhibitory assay against ECE-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115846((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((R)-5-m...)
Affinity DataKi:  1.30nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50023103(CHEMBL3298934)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21649((2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-(4-phenylpheny...)
Affinity DataKi:  1.5nM ΔG°:  -52.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21639((2S)-2-[2-(2,3-dihydro-1H-inden-1-yl)-3-sulfanylpr...)
Affinity DataKi:  1.80nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115843((2S)-2-[(2R)-2-[(1R)-5-bromo-2,3-dihydro-1H-inden-...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115842(2-(2-Indan-1-yl-3-mercapto-propionylamino)-3-(1H-i...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50269051(CHEMBL4075182)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Cnrs

LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKi:  2nMAssay Description:Specific activity of ACE was assayed in black 96-well microplates with or without various concentrations of inhibitors. N-Cbz-Phe-His-Leu was added, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50023104(CHEMBL3298935)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21654((2S)-2-[(2S)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  2.10nM ΔG°:  -51.5kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21644((2S)-3-(1H-indol-3-yl)-2-[(2S,3S)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.20nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21643(CGS-31,447 | [3-(naphthalen-1-yl)-1-{[(1S)-2-(4-ph...)
Affinity DataKi:  2.20nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21645((2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.40nM ΔG°:  -51.2kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21646((2S)-3-(1H-indol-3-yl)-2-[(2S,3R)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.5nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50023097(CHEMBL3298860)
Affinity DataKi:  2.5nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115850((S)-3-(1H-Indol-3-yl)-2-[(S)-3-mercapto-2-((R)-5-m...)
Affinity DataKi:  2.70nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50023069(CHEMBL3298859)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Cnrs

LigandPNGBDBM50115837(2-[2-(5-Cyano-indan-1-yl)-3-mercapto-propionylamin...)
Affinity DataKi:  3nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21657((2S)-3-(1H-indol-3-yl)-2-[(2R)-3-sulfanyl-2-[(1R)-...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21658((2S)-3-(1H-indol-3-yl)-2-[(2S)-3-sulfanyl-2-[(1R)-...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21635((2S)-3-(1H-indol-3-yl)-2-[3-phenyl-2-(sulfanylmeth...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50023131(CHEMBL3298940)
Affinity DataKi:  3.40nMAssay Description:Inhibition of recombinant human Neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50023131(CHEMBL3298940)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115840((S)-2-[(S)-2-(5-Bromo-indan-1-yl)-3-mercapto-propi...)
Affinity DataKi:  3.80nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115839(2-[2-(5-Hydroxy-indan-1-yl)-3-mercapto-propionylam...)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataKi:  4nM ΔG°:  -49.9kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Cnrs

LigandPNGBDBM50115840((S)-2-[(S)-2-(5-Bromo-indan-1-yl)-3-mercapto-propi...)
Affinity DataKi:  4.10nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50269062(CHEMBL4091227)
Affinity DataKi:  4.20nMAssay Description:Inhibition of recombinant human neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21640((2S)-3-(1H-indol-3-yl)-2-[3-sulfanyl-2-(1,2,3,4-te...)
Affinity DataKi:  4.5nM ΔG°:  -49.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Cnrs

LigandPNGBDBM50115850((S)-3-(1H-Indol-3-yl)-2-[(S)-3-mercapto-2-((R)-5-m...)
Affinity DataKi:  4.60nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50269087(CHEMBL4080935)
Affinity DataKi:  4.60nMAssay Description:Inhibition of recombinant human neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21636((2S)-3-(1H-indol-3-yl)-2-[3-(4-phenylphenyl)-2-(su...)
Affinity DataKi:  4.80nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21647((2S)-3-(1H-indol-3-yl)-2-[(2R,3S)-3-phenyl-2-(sulf...)
Affinity DataKi:  5nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115845(2-[2-(5-Bromo-indan-1-yl)-3-mercapto-propionylamin...)
Affinity DataKi:  5nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115841(3-(1H-Indol-3-yl)-2-[3-mercapto-2-(5-methoxy-indan...)
Affinity DataKi:  5nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21651((2S)-3-(1H-indol-3-yl)-2-[(2R,3S)-3-(4-phenylpheny...)
Affinity DataKi:  5nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21637((2S)-3-(1H-indol-3-yl)-2-[3-(naphthalen-2-yl)-2-(s...)
Affinity DataKi:  5.40nM ΔG°:  -49.1kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  5.5nMAssay Description:Inhibition of recombinant human Neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115849(3-(1H-Indol-3-yl)-2-[3-mercapto-2-(5-methylsulfany...)
Affinity DataKi:  6nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pharmaleads

Curated by ChEMBL
LigandPNGBDBM50269075(CHEMBL4089776)
Affinity DataKi:  7nMAssay Description:Inhibition of recombinant human neprilysin using Suc-Ala-Ala-Phe-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Cnrs

LigandPNGBDBM50115839(2-[2-(5-Hydroxy-indan-1-yl)-3-mercapto-propionylam...)
Affinity DataKi:  7nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEEF1AKMT4-ECE2 readthrough transcript protein(Homo sapiens (Human))
Pharmaleads

LigandPNGBDBM92503((2S)-2-[(2R)-2-(2,3-dihydro-1H-inden-1-yl)-3-sulfa...)
Affinity DataKi:  7.70nM IC50:  15.1nMAssay Description:Inhibitory assay against ECE-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Cnrs

LigandPNGBDBM50115836(3-(1H-Indol-3-yl)-2-[3-mercapto-2-(4-methoxy-indan...)
Affinity DataKi:  8nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21656((2S)-3-(1H-indol-3-yl)-2-[(2S)-3-sulfanyl-2-[(1S)-...)
Affinity DataKi:  8nM ΔG°:  -48.1kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50115838(2-[2-(5-Ethoxy-indan-1-yl)-3-mercapto-propionylami...)
Affinity DataKi:  8nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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