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TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM679453(5-(2-fluoro-6- hydroxy-4-(((6-oxo- 1,6-dihydropyri...)
Affinity DataIC50:  0.200nMAssay Description:The PTPN2 biochemical assay was performed as follows, a 5× stock solution of human PTPN2 (SRP5075, MilliporeSigma, Burlington, MA) and a 1.25× stock ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176023(US10047103, 56 | US9688695, 56)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286492(2-Methoxy-6-(6-methoxy-4-((6-(4-methoxytetrahydro-...)
Affinity DataIC50:  0.230nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286477(4-(6-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Affinity DataIC50:  0.230nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286479(US9518064, Example 98)
Affinity DataIC50:  0.290nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176082(US10047103, 115 | US9688695, 115)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 7(Mouse)
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at gardiquimod stimulated TRL7 in mouse whole blood assessed as inhibition of IL-6 production by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM175970(US10047103, 3 | US9605024, Example 3 | US9688695, ...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176039(US10047103, 72 | US9688695, 72)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176053(US10047103, 86 | US9688695, 86)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286495((S)-2-(1-Fluoroethyl)-6-(4-((6-(4-fluorotetrahydro...)
Affinity DataIC50:  0.310nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM364891(US9862730, Example 349)
Affinity DataIC50:  0.320nMAssay Description:The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM568223(US11420973, Example 101)
Affinity DataIC50:  0.340nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286494(6-(4-((6-(4-Fluorotetrahydro-2H-pyran-4-yl)pyridin...)
Affinity DataIC50:  0.350nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286478(6-(4-((2-(2-fluoropyridin-4-yl)pyrimidin-4-yl)meth...)
Affinity DataIC50:  0.360nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286421(US9518064, Example 37)
Affinity DataIC50:  0.360nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286493((S)-2-(1-Fluoroethyl)-6-(6-methoxy-4-((6-(4-methox...)
Affinity DataIC50:  0.360nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM566998(US11420958, Ex. No. 367)
Affinity DataIC50:  0.370nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286420(US9518064, Example 36)
Affinity DataIC50:  0.380nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286464(6-(4-((3-Fluoro-5-(2-methoxypyrimidin-5-yl)benzyl)...)
Affinity DataIC50:  0.390nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176003(US10047103, 36 | US9688695, 36)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176007(US10047103, 40 | US9688695, 40)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176061(US10047103, 94 | US9688695, 94)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50600788(CHEMBL5206065)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50600792(CHEMBL5189522)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM175988(US10047103, 21 | US9688695, 21)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286491((S)-4-(6-(((2-(2-(1-Fluoroethyl)imidazo[2,1-b][1,3...)
Affinity DataIC50:  0.410nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286490(4-(6-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Affinity DataIC50:  0.450nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286424(US9518064, Example 40)
Affinity DataIC50:  0.470nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286418(US9518064, Example 34)
Affinity DataIC50:  0.480nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286419(US9518064, Example 35)
Affinity DataIC50:  0.490nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286453(US9518064, Example 71)
Affinity DataIC50:  0.5nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176026(US10047103, 59 | US9688695, 59)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286419(US9518064, Example 35)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443999(US10660877, Example 588)
Affinity DataIC50:  0.5nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443583(US10660877, Example 166)
Affinity DataIC50:  0.5nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM566956(US11420958, Ex. No. 325)
Affinity DataIC50:  0.5nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM566939(US11420958, Ex. No. 308)
Affinity DataIC50:  0.5nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286424(US9518064, Example 40)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM566897(US11420958, Ex. No. 266)
Affinity DataIC50:  0.5nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286418(US9518064, Example 34)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM176019(US10047103, 52 | US9688695, 52)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443500(US10660877, Example 77)
Affinity DataIC50:  0.5nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM568205(N-(2-(dimethylamino)ethyl)-N,3-diethyl-2-(1H-pyrro...)
Affinity DataIC50:  0.5nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286423(US9518064, Example 39)
Affinity DataIC50:  0.530nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286436(US9518064, Example 52)
Affinity DataIC50:  0.560nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286467(2-Methoxy-6-(6-methoxy-4-((3-(5-(1-((tetrahydro-2H...)
Affinity DataIC50:  0.560nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286416(US9518064, Example 32)
Affinity DataIC50:  0.570nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM286449(6-(4-((3-(6-Chloropyridin-3-yl)-5-methoxybenzyl)ox...)
Affinity DataIC50:  0.570nMT: 25°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb Research & Early Development

Curated by ChEMBL
LigandPNGBDBM364941(US9862730, Example 399)
Affinity DataIC50:  0.590nMAssay Description:The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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