Compile Data Set for Download or QSAR
Found 111 with Last Name = 'pratt' and Initial = 'sa'
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161874(CHEMBL3794475)
Affinity DataIC50:  7.60nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314754(CHEMBL1088784 | N-(5-benzyl-4-phenyl-1,3-thiazol-2...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50116105(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Affinity DataIC50:  8.5nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161832(CHEMBL3792517)
Affinity DataIC50:  9.5nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161862(CHEMBL3793568)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161858(CHEMBL3793367)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161868(CHEMBL3793070)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161860(CHEMBL3793322)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161958(CHEMBL3794479)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161866(CHEMBL3794030)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161861(CHEMBL3792935)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161841(CHEMBL3793985)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161854(CHEMBL3794051)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161859(CHEMBL3792636)
Affinity DataIC50:  22nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314752(CHEMBL1092385 | N-[2-({[1-Phenyl-3-(trifluoromethy...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161867(CHEMBL3793277)
Affinity DataIC50:  24nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314753(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314738(CHEMBL1089182 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314730(CHEMBL1089874 | N-(2-(4-ethoxybenzamido)ethyl)-1-p...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314752(CHEMBL1092385 | N-[2-({[1-Phenyl-3-(trifluoromethy...)
Affinity DataIC50:  44nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314737(1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314751(6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161863(CHEMBL3793560)
Affinity DataIC50:  65nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161856(CHEMBL3793190)
Affinity DataIC50:  77nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314730(CHEMBL1089874 | N-(2-(4-ethoxybenzamido)ethyl)-1-p...)
Affinity DataIC50:  77nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314749(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161851(CHEMBL3793744)
Affinity DataIC50:  84nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314753(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  87nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161832(CHEMBL3792517)
Affinity DataIC50:  88nMAssay Description:Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-stimulated cAMP accumulation after 4 hrs by steady-gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314738(CHEMBL1089182 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  91nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314734(1-(4-Chlorophenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161853(CHEMBL3793781)
Affinity DataIC50:  97nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314741(CHEMBL1089208 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  98nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161844(CHEMBL3793329)
Affinity DataIC50:  140nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314736(1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161864(CHEMBL3794050)
Affinity DataIC50:  170nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314733(1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314732(CHEMBL1089875 | N-(2-(4-Ethoxybenzamido)ethyl)-3-m...)
Affinity DataIC50:  260nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314751(6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  370nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314736(1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  380nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314749(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Affinity DataIC50:  400nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314737(1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  600nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314741(CHEMBL1089208 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  610nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314732(CHEMBL1089875 | N-(2-(4-Ethoxybenzamido)ethyl)-3-m...)
Affinity DataIC50:  650nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314733(1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino...)
Affinity DataIC50:  650nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314755(5-benzyl-N-(2-(4-ethoxybenzamido)ethyl)-4-phenylth...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314735(1-Benzyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}-et...)
Affinity DataIC50:  770nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314735(1-Benzyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}-et...)
Affinity DataIC50:  790nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50161857(CHEMBL3793059)
Affinity DataIC50:  990nMAssay Description:Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50314731(CHEMBL1089304 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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