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TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
Affinity DataKi:  20nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164642(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  23nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164639(2'-3'-dideoxy-7-deaza-guaninetriphosphate | CHEMBL...)
Affinity DataKi:  25nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164652(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  34nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164654(CHEMBL370031 | [[[4-(2-amino-6-oxo-3,9-dihydropuri...)
Affinity DataKi:  37nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164637(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  45nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164638(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  46nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164647(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  47nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50145605(4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofura...)
Affinity DataKi:  51nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50370655(CHEMBL485652)
Affinity DataKi:  56nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164648(2'-deoxythymidine triphosphate | 5'-TTP | CHEMBL36...)
Affinity DataKi:  61nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164650(CHEMBL191725 | [[[3-fluoro-5-(5-methyl-2,4-dioxo-1...)
Affinity DataKi:  71nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164653(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  71nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataKi:  91nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164640(CHEMBL190609 | [[[[3-azido-5-(5-methyl-2,4-dioxo-1...)
Affinity DataKi:  94nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50138406(3TC Triphosphate | CHEMBL1230 | LAMIVUDINE | Lamiv...)
Affinity DataKi:  188nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164655(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  236nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164651(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  314nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164656(2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamm...)
Affinity DataKi:  438nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164645(CHEMBL192771 | [[[5-(4-amino-5-fluoro-2-oxo-1H-pyr...)
Affinity DataKi:  501nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164646(CHEMBL192371 | [[[5-(2,4-dioxo-1H-pyrimidin-1-yl)t...)
Affinity DataKi:  545nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Biota

Curated by ChEMBL
LigandPNGBDBM50164643(({[({[5-(4-amino-5-fluoro-2-oxo-1,2-dihydropyrimid...)
Affinity DataKi:  1.77E+3nMAssay Description:Inhibitory constant against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50274121(CHEMBL4127092)
Affinity DataIC50:  27nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRous sarcoma virus integrase(RSV-Pr-C)
Janssen Biopharma

US Patent
LigandPNGBDBM521555(((2S,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50:  30nMAssay Description:Standard RSV polymerase assays were conducted in the presence of 3 μL extract of RSV-infected cells in a reaction buffer containing 50 mM tris-a...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent

TargetRous sarcoma virus integrase(RSV-Pr-C)
Janssen Biopharma

US Patent
LigandPNGBDBM521557(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50:  30nMAssay Description:Standard RSV polymerase assays were conducted in the presence of 3 μL extract of RSV-infected cells in a reaction buffer containing 50 mM tris-a...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50274124(CHEMBL4125966 | US10793591, Compound 12)
Affinity DataIC50:  39nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(HRV-16)
Janssen Biopharma

US Patent
LigandPNGBDBM521557(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50:  40nMAssay Description:The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50544633(CHEMBL4641646)
Affinity DataIC50:  64nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50332459(((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataIC50:  99nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50524197(CHEMBL4555315 | US10793591, Compound 46)
Affinity DataIC50:  110nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRous sarcoma virus integrase(RSV-Pr-C)
Janssen Biopharma

US Patent
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2 | US20240140975...)
Affinity DataIC50:  120nMAssay Description:Standard RSV polymerase assays were conducted in the presence of 3 μL extract of RSV-infected cells in a reaction buffer containing 50 mM tris-a...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50544634(CHEMBL4632955)
Affinity DataIC50:  130nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50144942(2'-C-Me-guanosine | 2'-C-methyl-guanosine | 2'-C-m...)
Affinity DataIC50:  130nMAssay Description:Inhibition HCV NS5B-mediated RNA synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(HRV-16)
Janssen Biopharma

US Patent
LigandPNGBDBM521555(((2S,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50:  130nMAssay Description:The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50274118(CHEMBL4127030 | US10793591, Compound 7a)
Affinity DataIC50:  140nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM466313(US10793591, Compound 9)
Affinity DataIC50:  140nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50524193(CHEMBL4543543)
Affinity DataIC50:  150nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM466319(US10793591, Compound 44)
Affinity DataIC50:  150nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50544635(CHEMBL4640290)
Affinity DataIC50:  160nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50524191(CHEMBL4592496)
Affinity DataIC50:  190nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(HRV-16)
Janssen Biopharma

US Patent
LigandPNGBDBM521556(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50:  210nMAssay Description:The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent

TargetGenome polyprotein(HRV-16)
Janssen Biopharma

US Patent
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2 | US20240140975...)
Affinity DataIC50:  270nMAssay Description:The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50524198(CHEMBL4592592)
Affinity DataIC50:  280nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(HCV)
Janssen Biopharma

US Patent
LigandPNGBDBM521557(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50:  300nMAssay Description:The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50239939(CHEMBL4088430)
Affinity DataIC50:  300nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50544637(CHEMBL4635006)
Affinity DataIC50:  310nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50274117(CHEMBL4127921)
Affinity DataIC50:  330nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50524194(CHEMBL4454742)
Affinity DataIC50:  340nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(HCV)
Janssen Biopharma

US Patent
LigandPNGBDBM521555(((2S,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50:  400nMAssay Description:The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50544632(CHEMBL3422648)
Affinity DataIC50:  420nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled ribonucleotide monophosphates incorporation into R...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
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