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TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50608295(CHEMBL5271774)
Affinity DataKi:  0.0140nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM50227856((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50608296(CHEMBL5270286)
Affinity DataKi:  0.346nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM50183715(CHEMBL207305 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11551((3R)-N-hydroxy-2-[(4-methoxy-1,1-biphenyl-4-yl)met...)
Affinity DataKi:  0.400nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104967(CHEMBL419751 | N*4*-Hydroxy-2-(4-hydroxy-benzyl)-N...)
Affinity DataKi:  0.450nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM26526((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...)
Affinity DataKi:  0.560nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50104981(11-(2',6'-Difluoro-biphenyl-4-ylmethyl)-2,10-dioxo...)
Affinity DataKi:  0.640nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM11551((3R)-N-hydroxy-2-[(4-methoxy-1,1-biphenyl-4-yl)met...)
Affinity DataKi:  0.900nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11554((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...)
Affinity DataKi:  1nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi: <1nMAssay Description:Inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi: <1nMAssay Description:Inhibition of matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi: <1nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50102608(11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentad...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50102608(11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentad...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Bristol-Myers Squibb

LigandPNGBDBM11551((3R)-N-hydroxy-2-[(4-methoxy-1,1-biphenyl-4-yl)met...)
Affinity DataKi:  1.20nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50104974(2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50104973(2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataKi: <2.10nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127451(CHEMBL53643 | N-Hydroxy-2-[7-(4-methoxy-phenoxy)-1...)
Affinity DataKi: <2.10nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM11552((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...)
Affinity DataKi: <2.10nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127462(2-[7-(Biphenyl-4-yloxy)-1,1-dioxo-1,3,4,5-tetrahyd...)
Affinity DataKi: <2.10nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127481(2-(7-Benzyloxy-1,1-dioxo-1,3,4,5-tetrahydro-1lambd...)
Affinity DataKi: <2.10nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127451(CHEMBL53643 | N-Hydroxy-2-[7-(4-methoxy-phenoxy)-1...)
Affinity DataKi: <2.80nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127462(2-[7-(Biphenyl-4-yloxy)-1,1-dioxo-1,3,4,5-tetrahyd...)
Affinity DataKi: <2.80nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataKi: <2.80nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127450(CHEMBL51966 | N-Hydroxy-2-(7-hydroxy-1,1-dioxo-1,3...)
Affinity DataKi: <2.80nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127481(2-(7-Benzyloxy-1,1-dioxo-1,3,4,5-tetrahydro-1lambd...)
Affinity DataKi: <2.80nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127465(2-[1,1-Dioxo-7-(4-trifluoromethyl-phenoxy)-1,3,4,5...)
Affinity DataKi: <2.80nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50104977(11-(3',5'-Dichloro-biphenyl-4-ylmethyl)-2,10-dioxo...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127480(2-(1,1-Dioxo-7-phenyl-1,3,4,5-tetrahydro-1lambda*6...)
Affinity DataKi:  2.80nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127475(2-(7-Benzyloxy-1,1-dioxo-1,3,4,5-tetrahydro-1lambd...)
Affinity DataKi: <2.80nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Bristol-Myers Squibb

LigandPNGBDBM11554((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...)
Affinity DataKi:  3nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127473(2-(1,1-Dioxo-7-phenoxy-1,3,4,5-tetrahydro-1lambda*...)
Affinity DataKi:  3nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  3.20nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50104967(CHEMBL419751 | N*4*-Hydroxy-2-(4-hydroxy-benzyl)-N...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11552((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...)
Affinity DataKi: <3.30nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

LigandPNGBDBM50127475(2-(7-Benzyloxy-1,1-dioxo-1,3,4,5-tetrahydro-1lambd...)
Affinity DataKi:  3.60nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50104978(2,10-Dioxo-11-(3'-trifluoromethyl-biphenyl-4-ylmet...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11548(CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...)
Affinity DataKi:  3.80nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50104979(2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50102608(11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentad...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50104967(CHEMBL419751 | N*4*-Hydroxy-2-(4-hydroxy-benzyl)-N...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50104976(11-(3',5'-Bis-trifluoromethyl-biphenyl-4-ylmethyl)...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM50120688(CHEMBL146896 | N-Hydroxy-2-[3-(4-methoxy-phenyl)-3...)
Affinity DataKi:  4.80nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Bristol-Myers Squibb

LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi: <5nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127472(2-[7-(3,5-Dimethoxy-benzyloxy)-1,1-dioxo-1,3,4,5-t...)
Affinity DataKi:  5nMAssay Description:In vitro inhibitory activity against porcine tumor necrosis factor alpha converting enzyme (pTACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Bristol-Myers Squibb

LigandPNGBDBM11552((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...)
Affinity DataKi: <5nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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