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TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231938((2,5-dimethyloxazol-4-yl)methyl (R)-1-((4S,5S,7R)-...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462123(CHEMBL4250984)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50422052(CHEMBL109952 | L-700417)
Affinity DataKi:  0.370nMAssay Description:Inhibition of recombinant HIV protease expressed in inclusion bodies of Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of recombinant HIV protease expressed in inclusion bodies of Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462118(CHEMBL4243296)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231937(CHEMBL403268 | N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462121(CHEMBL4240868)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50035097(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462120(CHEMBL4243361)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462131(CHEMBL2182010)
Affinity DataKi:  2.70nMAssay Description:Inhibition of HIV proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462119(CHEMBL4247145)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50421951(CHEMBL1744002)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462121(CHEMBL4240868)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50421931(CHEMBL1744009)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462123(CHEMBL4250984)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231932(CHEMBL253930 | N1-((2S,3R)-3-hydroxy-4-((1-(methyl...)
Affinity DataKi:  27nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50421931(CHEMBL1744009)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462119(CHEMBL4247145)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50035097(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462115(CHEMBL2311598)
Affinity DataKi:  107nMAssay Description:Inhibition of bovine alpha-chymotrypsin using succinyl Ala-Ala-Pro-Phe-p-nitroanilide as substrate after 1 hr by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50421951(CHEMBL1744002)
Affinity DataKi:  206nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231933(CHEMBL253929 | N1-((2S,3R)-4-((1H-indol-6-yl)methy...)
Affinity DataKi:  230nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462118(CHEMBL4243296)
Affinity DataKi:  243nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231941(CHEMBL253103 | N1-((2S,3R)-3-hydroxy-4-(isopropyla...)
Affinity DataKi:  425nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50462120(CHEMBL4243361)
Affinity DataKi:  460nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231931(CHEMBL403483 | N1-((2S,3R)-4-(3-methoxybenzylamino...)
Affinity DataKi:  552nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231940(CHEMBL252276 | N1-((2S,3R)-3-hydroxy-4-((S)-1-(iso...)
Affinity DataKi:  564nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231934(CHEMBL403269 | N1-((2S,3R)-4-(3-methoxybenzylamino...)
Affinity DataKi:  617nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231939(CHEMBL404144 | N1-((2S,3R)-4-(3-methoxybenzylamino...)
Affinity DataKi:  894nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231936(CHEMBL253931 | N1-((2R,3S)-1-(3-methoxybenzylamino...)
Affinity DataKi:  916nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231935((2,5-dimethyloxazol-4-yl)methyl (R)-1-((2S,3R)-4-(...)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to recombinant memapsin 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555248(USRE49080, Example 16)
Affinity DataIC50:  0.150nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555251(USRE49080, Example 21)
Affinity DataIC50:  0.200nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555247(USRE49080, Example 15)
Affinity DataIC50:  0.200nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555242(USRE49080, Example 8)
Affinity DataIC50:  0.25nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555255(USRE49080, Example 28)
Affinity DataIC50:  0.330nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555263(USRE49080, Example 42)
Affinity DataIC50:  0.350nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555252(USRE49080, Example 22)
Affinity DataIC50:  0.400nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50560402(LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...)
Affinity DataIC50:  0.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555250(USRE49080, Example 20)
Affinity DataIC50:  0.550nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555249(USRE49080, Example 17)
Affinity DataIC50:  0.800nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555270(USRE49080, Example 66)
Affinity DataIC50:  0.900nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50231937(CHEMBL403268 | N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3...)
Affinity DataIC50:  1nMAssay Description:Inhibition of memapsin 2 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555271(USRE49080, Example 69)
Affinity DataIC50:  1.20nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555257(USRE49080, Example 31)
Affinity DataIC50:  1.20nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555253(USRE49080, Example 24)
Affinity DataIC50:  1.30nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555245(USRE49080, Example 11)
Affinity DataIC50:  1.40nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555254(USRE49080, Example 25)
Affinity DataIC50:  1.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555272(USRE49080, Example 71)
Affinity DataIC50:  1.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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