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TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065118(CHEMBL311931 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065123(CHEMBL420031 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065121(CHEMBL310416 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065124(CHEMBL68085 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065112(CHEMBL81269 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065111(CHEMBL80029 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4582(4-anilinoquinazoline deriv. 10o | N-{4-[(3-bromoph...)
Affinity DataIC50:  2nMpH: 7.4 T: 22°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065125(CHEMBL311230 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Affinity DataIC50:  2nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Affinity DataIC50:  2nMpH: 7.4 T: 22°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065129(CHEMBL312036 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065128(CHEMBL81133 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3.10nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065119(CHEMBL70981 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065116(CHEMBL81755 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065122(CHEMBL306970 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065127(CHEMBL71797 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  4.10nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065132(CHEMBL420216 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065121(CHEMBL310416 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  4.5nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065120(CHEMBL302709 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  4.60nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065117(CHEMBL304956 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4568(4-anilinoquinazoline deriv. 10a | N-{4-[(3-bromoph...)
Affinity DataIC50:  6nMpH: 7.4 T: 22°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065122(CHEMBL306970 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [3H]-AVP from vasopressin receptor (V1a) from human platelet membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM50161879(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(3...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50161879(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(3...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065131(CHEMBL82376 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4566(4-anilinoquinazoline deriv. 1 | CHEMBL91867 | N-{4...)
Affinity DataIC50:  8nMpH: 7.4 T: 22°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065125(CHEMBL311230 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  8.30nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065114(CHEMBL314344 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  8.30nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4579(4-anilinoquinazoline deriv. 10l | N-{4-[(3-bromoph...)
Affinity DataIC50:  9nMpH: 7.4 T: 22°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM50161948(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(n...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50161903(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065120(CHEMBL302709 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  10nMAssay Description:Displacement of (Phe-3,4,5-H) Vasopressin from V1a recptor from rat liver membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065130(CHEMBL71305 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  10.2nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50:  11nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50:  11nMpH: 7.4 T: 22°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM50161903(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(2...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4569(4-anilinoquinazoline deriv. 10b | N-{4-[(3-bromoph...)
Affinity DataIC50:  12nMpH: 7.4 T: 22°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50161956(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4592((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50:  14nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065126(CHEMBL73286 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4568(4-anilinoquinazoline deriv. 10a | N-{4-[(3-bromoph...)
Affinity DataIC50:  14nMAssay Description:The HER-2 kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50161883(4-Dimethylamino-but-2-enoic acid [4-(1-benzyl-1H-i...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-AVP from vasopressin receptor (V1a) from human platelet membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065129(CHEMBL312036 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-AVP from vasopressin receptor (V1a) from human platelet membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM50161911(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(n...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM50161926(4-Thiomorpholin-4-yl-but-2-enoic acid [4-(4-benzyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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