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TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50020522(1-(((4-carbamoylpyridinium-1-yl)methoxy)methyl)-2-...)
Affinity DataKd:  7.00E+4nMAssay Description:Reactivation of VX-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50020522(1-(((4-carbamoylpyridinium-1-yl)methoxy)methyl)-2-...)
Affinity DataKd:  2.00E+5nMAssay Description:Reactivation of tabun-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50458949(CHEMBL4216666)
Affinity DataKd:  5.70E+3nMAssay Description:Reactivation of ethyl paraoxon-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50458950(CHEMBL77510 | Pyridine-2-Carbaldehyde Oxime)
Affinity DataKd:  2.10E+5nMAssay Description:Reactivation of NIMP-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50020522(1-(((4-carbamoylpyridinium-1-yl)methoxy)methyl)-2-...)
Affinity DataKd:  9.00E+4nMAssay Description:Reactivation of NIMP-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50458950(CHEMBL77510 | Pyridine-2-Carbaldehyde Oxime)
Affinity DataKd:  4.00E+5nMAssay Description:Reactivation of ethyl paraoxon-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  5.00E+5nMAssay Description:Reactivation of NIMP-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50005566(CHEMBL139018 | CHEMBL3234588)
Affinity DataKd:  2.00E+4nMAssay Description:Reactivation of NIMP-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50458949(CHEMBL4216666)
Affinity DataKd:  1.15E+4nMAssay Description:Reactivation of NIMP-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50458950(CHEMBL77510 | Pyridine-2-Carbaldehyde Oxime)
Affinity DataKd:  2.10E+5nMAssay Description:Reactivation of VX-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50458950(CHEMBL77510 | Pyridine-2-Carbaldehyde Oxime)
Affinity DataKd:  7.90E+5nMAssay Description:Reactivation of tabun-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50458949(CHEMBL4216666)
Affinity DataKd:  1.04E+4nMAssay Description:Reactivation of tabun-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50020522(1-(((4-carbamoylpyridinium-1-yl)methoxy)methyl)-2-...)
Affinity DataKd:  8.00E+5nMAssay Description:Reactivation of ethyl paraoxon-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50005579(CHEMBL139148 | Obidoxime)
Affinity DataKd:  5.50E+5nMAssay Description:Reactivation of ethyl paraoxon-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM50458949(CHEMBL4216666)
Affinity DataKd:  2.13E+4nMAssay Description:Reactivation of VX-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459897(CHEMBL4226319)
Affinity DataKd:  10nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459898(CHEMBL4227907)
Affinity DataKd:  4.60nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459900(CHEMBL4228346)
Affinity DataKd:  725nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459901(CHEMBL4226591)
Affinity DataKd:  13nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459902(CHEMBL4227342)
Affinity DataKd:  270nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459903(CHEMBL4226837)
Affinity DataKd:  275nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459904(CHEMBL4227097)
Affinity DataKd:  130nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459896(CHEMBL4226250)
Affinity DataKd:  245nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459908(CHEMBL4224757)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459909(CHEMBL4226693)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459910(CHEMBL4228790)
Affinity DataKd:  104nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459911(CHEMBL4225766)
Affinity DataKd:  4nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Arvinas

Curated by ChEMBL
LigandPNGBDBM50459912(CHEMBL4225995)
Affinity DataKd:  1.04E+3nMAssay Description:Binding affinity to human full length wild-type TBK1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459898(CHEMBL4227907)
Affinity DataKd:  70nMAssay Description:Binding affinity to human full length wild-type IKKepsilon expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492348(CHEMBL2403866)
Affinity DataEC50:  27nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492349(CHEMBL2403861)
Affinity DataEC50:  25nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492350(CHEMBL2403858)
Affinity DataEC50:  30nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492351(CHEMBL2403857)
Affinity DataEC50:  40nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492360(CHEMBL2403856)
Affinity DataEC50:  30nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492354(CHEMBL2403862)
Affinity DataEC50:  30nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492356(CHEMBL2403854)
Affinity DataEC50:  20nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492361(CHEMBL2403864)
Affinity DataEC50:  20nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492355(CHEMBL2403859)
Affinity DataEC50:  60nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492347(CHEMBL2403852)
Affinity DataEC50:  70nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492353(CHEMBL2403865)
Affinity DataEC50:  53nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492365(CHEMBL2403860)
Affinity DataEC50:  480nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50492364(CHEMBL2403863)
Affinity DataEC50:  30nMAssay Description:Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
International Cooperation Base of Pesticide and Green Synthesis (Hubei)

Curated by ChEMBL
LigandPNGBDBM50504454(CHEMBL4593275)
Affinity DataKd:  5.40E+4nMAssay Description:Binding affinity to human FBPase expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant at 100 uM by UV-visible spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50542954(CHEMBL4639202)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of human PD1/PDL1 protein-protein interaction in human PBMC-derived CD3-positive T cells co-cultured with human Hep3B cells expressing hum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552019(CHEMBL4740172)
Affinity DataKd:  3.31E+4nMAssay Description:Binding affinity to ERalpha (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552020(CHEMBL4777424)
Affinity DataKd:  4.72E+4nMAssay Description:Binding affinity to ERalpha (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetInterleukin-6 receptor subunit beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552019(CHEMBL4740172)
Affinity DataKd:  1.43E+5nMAssay Description:Binding affinity to immobilized GP130 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetInterleukin-6 receptor subunit beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552020(CHEMBL4777424)
Affinity DataKd:  3.80E+3nMAssay Description:Binding affinity to immobilized GP130 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50555147(CHEMBL4748886)
Affinity DataKd:  88nMAssay Description:Binding affinity to human PD-L1 by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50555147(CHEMBL4748886)
Affinity DataKd:  174nMAssay Description:Binding affinity to mouse PD-L1 by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
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