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TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50462626(CHEMBL4127893)
Affinity DataKd:  5.26E+3nMAssay Description:Binding affinity to recombinant human N-terminal GSt-tagged TNKS1 (1000 to 1328 residues) expressed in baculovirus infected Sf9 cells by surface plas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50462627(CHEMBL1958308)
Affinity DataKd:  21nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged TNKS2 (Ser959 to Gly1166 residues) expressed in Escherichia coli by surface plasmon reson...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50462627(CHEMBL1958308)
Affinity DataKd:  520nMAssay Description:Binding affinity to recombinant human N-terminal GSt-tagged TNKS1 (1000 to 1328 residues) expressed in baculovirus infected Sf9 cells by surface plas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha/beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM11323(CHEMBL177820 | 4,5,6,7-tetrabromo-1H-1,2,3-benzotr...)
Affinity DataKd:  790nMAssay Description:Binding affinity to recombinant human CK2alpha/beta expressed in Escherichia coli by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50188594(CHEMBL1086580 | CHEBI:62878 | US20240279201, Compo...)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged TNKS2 (Ser959 to Gly1166 residues) expressed in Escherichia coli by surface plasmon reson...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50462628(CHEMBL4239155)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged TNKS2 (Ser959 to Gly1166 residues) expressed in Escherichia coli by surface plasmon reson...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50462626(CHEMBL4127893)
Affinity DataKd:  1.25E+3nMAssay Description:Binding affinity to recombinant human PARP1 expressed in baculovirus infected Sf9 cells by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50462629(CHEMBL3594248)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant human N-terminal His-tagged TNKS2 (Ser959 to Gly1166 residues) expressed in Escherichia coli by surface plasmon reson...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492756(CHEMBL2413566)
Affinity DataKd:  72nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492757(CHEMBL2413581)
Affinity DataKd:  89nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492758(CHEMBL2413580)
Affinity DataKd:  107nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492759(CHEMBL2413569)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492755(CHEMBL2413587)
Affinity DataKd:  84nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492760(CHEMBL2413586)
Affinity DataKd:  191nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492761(CHEMBL2413582)
Affinity DataKd:  201nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492753(CHEMBL2413570)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492762(CHEMBL2413565)
Affinity DataKd:  55nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492763(CHEMBL2413573)
Affinity DataKd:  237nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492754(CHEMBL2413568)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492764(CHEMBL2413571)
Affinity DataKd:  10nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50492765(CHEMBL2413579)
Affinity DataKd:  151nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA topoisomerase 1(Human)
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50008935(CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...)
Affinity DataKd:  26.5nMAssay Description:Binding affinity to topoisomerase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetWee1-like protein kinase(Human)
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50378910(TOPOPYRONE C)
Affinity DataKd:  1.35nMAssay Description:Binding affinity to weel kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA topoisomerase 1(Human)
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50378911(CHEMBL1813808)
Affinity DataKd:  0.296nMAssay Description:Binding affinity to topoisomerase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA topoisomerase 1(Human)
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50378912(CHEMBL1813809)
Affinity DataKd:  2.65nMAssay Description:Binding affinity to topoisomerase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | N6-Isopentenyladenosine | CHEMBL1163...)
Affinity DataKd:  1.21E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H14-H15 of isopent...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | N6-Isopentenyladenosine | CHEMBL1163...)
Affinity DataKd:  5.50E+5nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H11 of isopentenyl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | N6-Isopentenyladenosine | CHEMBL1163...)
Affinity DataKd:  2.21E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H12 of isopentenyl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | N6-Isopentenyladenosine | CHEMBL1163...)
Affinity DataKd:  2.02E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H2/H8 of purine ri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50478489(Crambescidin 816 HCl | CRAMBESCIDIN 816 HYDROCHLOR...)
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity at voltage-dependent L-type calcium channel in mouse neurobalstoma-rat glioma NG 108-15 hybrid cells assessed as inhibition of KC...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of full length HDAC3 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50: 68nMAssay Description:Inhibition of full length HDAC1 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50: 179nMAssay Description:Inhibition of full length HDAC2 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50464480(CHEMBL4282628)
Affinity DataIC50: 180nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50464484(CHEMBL4290910)
Affinity DataIC50: 260nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339570(4'-(1-Phenylsulfanylmethyl-1H-[1,2,3]triazol-4-yl)...)
Affinity DataIC50: 400nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50061980(CHEMBL3394323)
Affinity DataIC50: 410nMAssay Description:Inhibition of mPGES-1 in interleukin-1beta-stimulated human A549 cells microsomal membranes assessed as reduction in PGE2 formation incubated for 15 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50464486(CHEMBL4293214)
Affinity DataIC50: 540nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50464479(CHEMBL4283041)
Affinity DataIC50: 600nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339571(4-{4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]...)
Affinity DataIC50: 600nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386165(CHEMBL2042365)
Affinity DataIC50: 680nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50539779(CHEMBL4647475)
Affinity DataIC50: 700nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 release using PGH2 as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339571(4-{4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli MV1190 by cell free assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339572(4'-(1-Phenylsulfanylmethyl-1H-[1,2,3]triazol-4-yl)...)
Affinity DataIC50: 900nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386165(CHEMBL2042365)
Affinity DataIC50: 900nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50390010(CHEMBL2071516)
Affinity DataIC50: 900nMAssay Description:Inhibition of mPGES-1-mediated PGE2 formation in IL-1beta-stimulated human A549 cells preincubated for 10 mins measured after 1 min by RP-HPLC analys...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386164(CHEMBL2042366)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Mouse)
University of Brussels

Curated by ChEMBL
LigandPNGBDBM50101817(CHEBI:7565 | Adalat | Adalat Cc | Afeditab Cr | BA...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at voltage-dependent L-type calcium channel in mouse neurobalstoma-rat glioma NG 108-15 hybrid cells assessed as inhibition of KC...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6B(Human)
Institute of Biomolecular Chemistry (Icb)

Curated by ChEMBL
LigandPNGBDBM50535443(CHEMBL4591907)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human JMJD3 expressed in baculovirus infected Sf9 cells using biotinylated histone H3 peptide as substrate incubated for 15...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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