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TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataIC50:  1.20nMAssay Description:Competitive binding affinity to His-tagged human VDR LBD (156 to 453 residues) expressed in Escherichia coli BL23 (DE3) cells in presence of 1,25D3 b...More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of fluormone from human full length VDR after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455852(CHEMBL4209452)
Affinity DataIC50:  3.5nMAssay Description:Displacement of fluormone from human full length VDR after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455853(CHEMBL4202828)
Affinity DataIC50:  4.5nMAssay Description:Displacement of fluormone from human full length VDR after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455855(CHEMBL4202601)
Affinity DataIC50:  5.60nMAssay Description:Displacement of fluormone from human full length VDR after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455851(CHEMBL4203540)
Affinity DataIC50:  8.30nMAssay Description:Displacement of fluormone from human full length VDR after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455854(CHEMBL4203464)
Affinity DataIC50:  10nMAssay Description:Displacement of fluormone from human full length VDR after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50589996(CHEMBL5182683)
Affinity DataIC50:  15.7nMAssay Description:Competitive binding affinity to His-tagged human VDR LBD (156 to 453 residues) expressed in Escherichia coli BL23 (DE3) cells in presence of 1,25D3 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50589995(CHEMBL5175578)
Affinity DataIC50:  27.3nMAssay Description:Competitive binding affinity to His-tagged human VDR LBD (156 to 453 residues) expressed in Escherichia coli BL23 (DE3) cells in presence of 1,25D3 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397076(CHEMBL2171449)
Affinity DataEC50:  2.20nMAssay Description:Transactivation of full length human VDR expressed in human HeLa cells assessed as increase in CYP24 transcription after 18 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397077(CHEMBL2171450)
Affinity DataEC50:  0.5nMAssay Description:Transactivation of full length human VDR expressed in human HeLa cells assessed as increase in CYP24 transcription after 18 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50409926(CHEMBL2112314)
Affinity DataEC50:  0.400nMAssay Description:Effective concentration required for inhibition of Vitamin D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50409927(CHEMBL2112315)
Affinity DataEC50:  0.350nMAssay Description:Effective concentration required for inhibition of Vitamin D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50241974(CHEMBL4099875)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50241975(CHEMBL4060864)
Affinity DataEC50: >100nMAssay Description:Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50241976(CHEMBL4088053)
Affinity DataEC50: >100nMAssay Description:Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50241977(CHEMBL4066758)
Affinity DataEC50: >100nMAssay Description:Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at VDR in human MCF7 cells assessed as increase in transcription of CYP24A1 gene after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455853(CHEMBL4202828)
Affinity DataEC50:  5.60nMAssay Description:Agonist activity at VDR in human MCF7 cells assessed as increase in transcription of CYP24A1 gene after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455854(CHEMBL4203464)
Affinity DataEC50:  9nMAssay Description:Agonist activity at VDR in human MCF7 cells assessed as increase in transcription of CYP24A1 gene after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455852(CHEMBL4209452)
Affinity DataEC50:  29nMAssay Description:Agonist activity at VDR in human MCF7 cells assessed as increase in transcription of CYP24A1 gene after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455851(CHEMBL4203540)
Affinity DataEC50:  10nMAssay Description:Agonist activity at VDR in human MCF7 cells assessed as increase in transcription of CYP24A1 gene after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50455855(CHEMBL4202601)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at VDR in human MCF7 cells assessed as increase in transcription of CYP24A1 gene after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50496699(CHEMBL3220716)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50496700(CHEMBL3220717)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50496700(CHEMBL3220717)
Affinity DataKd:  1.80E+3nMAssay Description:Agonist activity at zebrafish VDR LBD assessed as binding affinity to TAMRA-labeled SRC-1 peptide by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50496701(CHEMBL3220718)
Affinity DataKd:  1.80E+3nMAssay Description:Agonist activity at zebrafish VDR LBD assessed as binding affinity to TAMRA-labeled SRC-1 peptide by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50496701(CHEMBL3220718)
Affinity DataEC50:  0.25nMAssay Description:Agonist activity at zebrafish gal4-VDR LBD expressed in human MCF7 cells by luciferase reporter gene based transactivation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50496699(CHEMBL3220716)
Affinity DataKd:  3.30E+3nMAssay Description:Agonist activity at zebrafish VDR LBD assessed as binding affinity to TAMRA-labeled SRC-1 peptide by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to zebrafish VDR LBD assessed as Kd for fluorescein-labeled SRC1 NR2 peptide binding by micro-scale thermophoresis methodMore data for this Ligand-Target Pair
TargetVitamin D3 receptor A(Danio rerio)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50409927(CHEMBL2112315)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to zebrafish VDR LBD assessed as Kd for fluorescein-labeled SRC1 NR2 peptide binding by micro-scale thermophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  3nMAssay Description:Induction of CYP24A1 (unknown orgin) transcriptional activity trasfected in human MCF7 cells incuabted for 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50589995(CHEMBL5175578)
Affinity DataEC50:  5.60nMAssay Description:Induction of CYP24A1 (unknown orgin) transcriptional activity trasfected in human MCF7 cells incuabted for 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50589996(CHEMBL5182683)
Affinity DataEC50:  3nMAssay Description:Induction of CYP24A1 (unknown orgin) transcriptional activity trasfected in human MCF7 cells incuabted for 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397074(CHEMBL2171447)
Affinity DataEC50:  2.80nMAssay Description:Transactivation of full length human VDR expressed in human HeLa cells assessed as increase in CYP24 transcription after 18 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397075(CHEMBL2171446)
Affinity DataEC50:  49nMAssay Description:Transactivation of full length human VDR expressed in human HeLa cells assessed as increase in CYP24 transcription after 18 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  2.5nMAssay Description:Transactivation of full length human VDR expressed in human HeLa cells assessed as increase in CYP24 transcription after 18 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397073(CHEMBL2171448)
Affinity DataEC50:  5nMAssay Description:Transactivation of GAL4-fused VDR ligand binding domain expressed in human HeLa cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50143770((1R,3S)-5-[2-[(3aS,7aR)-1-((R)-5-Hydroxy-1,5-dimet...)
Affinity DataEC50:  0.180nMAssay Description:Effective concentration required for inhibition of Vitamin D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50236238((3alpha,5beta)-3-hydroxycholan-24-oic acid | 3alph...)
Affinity DataKd:  1.89E+4nMAssay Description:Binding affinity to N-terminal His-tagged human VDR LBD (118 to 427) by reverse isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50236238((3alpha,5beta)-3-hydroxycholan-24-oic acid | 3alph...)
Affinity DataKd:  9.52E+3nMAssay Description:Binding affinity to N-terminal His-tagged human VDR LBD low-affinity site (118 to 427) by direct isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50236238((3alpha,5beta)-3-hydroxycholan-24-oic acid | 3alph...)
Affinity DataKd:  330nMAssay Description:Binding affinity to N-terminal His-tagged human VDR LBD canonical site (118 to 427) by direct isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397074(CHEMBL2171447)
Affinity DataEC50:  1.70nMAssay Description:Transactivation of GAL4-fused VDR ligand binding domain expressed in human HeLa cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University of Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  1nMAssay Description:Transactivation of GAL4-fused VDR ligand binding domain expressed in human HeLa cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank