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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425042((R)-3-(Dimethylamino)Butyl Dimethylcarbamate | CHE...)
Affinity DataEC50:  720nMAssay Description:Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425041(CHEMBL2312565)
Affinity DataEC50:  1.20E+3nMAssay Description:Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425040(CHEMBL2312564)
Affinity DataEC50:  1.90E+4nMAssay Description:Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425042((R)-3-(Dimethylamino)Butyl Dimethylcarbamate | CHE...)
Affinity DataEC50:  1.58E+4nMAssay Description:Agonist activity at human 3:2 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425041(CHEMBL2312565)
Affinity DataEC50:  2.30E+4nMAssay Description:Agonist activity at human 3:2 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-...)
Affinity DataEC50:  1.60E+3nMAssay Description:Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50425040(CHEMBL2312564)
Affinity DataEC50:  3.40E+4nMAssay Description:Agonist activity at human 3:2 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50088453(CHEMBL72433 | NS3570, 5 | 1-(6-bromo-5-ethoxypyrid...)
Affinity DataKi:  0.0670nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0.0970nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50088453(CHEMBL72433 | NS3570, 5 | 1-(6-bromo-5-ethoxypyrid...)
Affinity DataKi:  0.25nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50088454(NS3920, 4 | CHEMBL306387 | 1-(6-bromopyridin-3-yl)...)
Affinity DataKi:  0.320nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  0.330nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM92377(NS3573, 2)
Affinity DataKi:  0.620nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50088438(CHEMBL71085 | 1-Pyridin-3-yl-[1,4]diazepane | NS35...)
Affinity DataKi:  0.720nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50088437(CHEMBL303889 | NS3570, 3 | 1-(5-Phenyl-pyridin-3-y...)
Affinity DataKi:  0.800nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | NSC_22407 | Cytisine | Cytisine-(-)...)
Affinity DataKi:  0.950nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50088454(NS3920, 4 | CHEMBL306387 | 1-(6-bromopyridin-3-yl)...)
Affinity DataKi:  1.30nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM92377(NS3573, 2)
Affinity DataKi:  2.20nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50088438(CHEMBL71085 | 1-Pyridin-3-yl-[1,4]diazepane | NS35...)
Affinity DataKi:  3.10nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Copenhagen

LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  6nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | NSC_22407 | Cytisine | Cytisine-(-)...)
Affinity DataKi:  8.20nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50088437(CHEMBL303889 | NS3570, 3 | 1-(5-Phenyl-pyridin-3-y...)
Affinity DataKi:  8.90nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataKi:  18nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50425041(CHEMBL2312565)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP linked to ion channel portion of 5-HT3A receptor expressed in HEK293 cells after 4 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50425042((R)-3-(Dimethylamino)Butyl Dimethylcarbamate | CHE...)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP linked to ion channel portion of 5-HT3A receptor expressed in HEK293 cells after 4 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  83nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP linked to ion channel portion of 5-HT3A receptor expressed in HEK293 cells after 4 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50088438(CHEMBL71085 | 1-Pyridin-3-yl-[1,4]diazepane | NS35...)
Affinity DataKi:  136nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  170nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50088454(NS3920, 4 | CHEMBL306387 | 1-(6-bromopyridin-3-yl)...)
Affinity DataKi:  190nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | NSC_22407 | Cytisine | Cytisine-(-)...)
Affinity DataKi:  295nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50088453(CHEMBL72433 | NS3570, 5 | 1-(6-bromo-5-ethoxypyrid...)
Affinity DataKi:  847nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
University of Copenhagen

LigandPNGBDBM50425040(CHEMBL2312564)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP linked to ion channel portion of 5-HT3A receptor expressed in HEK293 cells after 4 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM92377(NS3573, 2)
Affinity DataKi:  9.97E+3nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50088437(CHEMBL303889 | NS3570, 3 | 1-(5-Phenyl-pyridin-3-y...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-...)
Affinity DataKi:  1.70E+5nMAssay Description:Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50425040(CHEMBL2312564)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50425043(CHEMBL2312563)
Affinity DataKi:  1.00E+6nMAssay Description:Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50425041(CHEMBL2312565)
Affinity DataKi:  1.00E+6nMAssay Description:Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Copenhagen

LigandPNGBDBM50425042((R)-3-(Dimethylamino)Butyl Dimethylcarbamate | CHE...)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed