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TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50366292(Dehydroroemerine)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of Net1 (149 to 501 residues) (unknown origin) interaction with GDP-loaded His-tagged RhoA F25N mutant (1 to 180 residues) assessed as red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetRho guanine nucleotide exchange factor 1(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50056922(cid_73677 | CHEMBL173530 | 1,4-Dihydroxy-10-methox...)
Affinity DataIC50: 1.87E+5nMAssay Description:Inhibition of p115 DHPH22 domain (395 to 766 residues) (unknown origin) interaction with GDP-loaded His-tagged RhoA F25N mutant (1 to 180 residues) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630076(CHEMBL5439741)
Affinity DataKi: <1nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630083(CHEMBL5402401)
Affinity DataKi: <1nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630092(CHEBI:66435 | Schweinfurthin E | SCHWEINFURTHIN E)
Affinity DataKi: <1nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630093(CHEBI:66352 | Vedelianin | VEDELIANIN)
Affinity DataKi: <1nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630094(CHEBI:66437 | Schweinfurthin G | SCHWEINFURTHIN G)
Affinity DataKi: <1nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Institut De Chimie Des Substances Naturelles (Icsn)

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <1nMAssay Description:Displacement of fluorescein-labeled BAK from His-tagged BCL-XL (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630095(CHEBI:66436 | Schweinfurthin F | SCHWEINFURTHIN F)
Affinity DataKi:  6nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM708864((7aR*9R*,11aR*)-9-hydroxy-6- (methoxymethoxy)-8,8,...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM708866((7aR*,9R*,11aR*)-6,9-dihydroxy- 8,8,11a-trimethyl-...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM708868((7aR,9R,11aR)-6,9-dihydroxy- 8,8,11a-trimethyl-3-p...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM708870((7aS,9S,11aS)-6,9-dihydroxy- 8,8,11a-trimethyl-3-p...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630078(CHEMBL5418635)
Affinity DataKi:  16nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630089(CHEMBL5397075)
Affinity DataKi:  31nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630090(CHEMBL5401329)
Affinity DataKi:  37nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630088(CHEMBL5416867)
Affinity DataKi:  43nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630075(CHEMBL5414636)
Affinity DataKi:  46nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM708867((7aR,9R,11aR)-9-hydroxy-6- (methoxymethoxy)-8,8,11...)
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM708871((7aR,9R,11aR)-9-hydroxy-6- (methoxymethoxy)-3-(4- ...)
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630080(CHEMBL5433096)
Affinity DataKi:  64nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50314864(CHEMBL4172927)
Affinity DataKi:  90nMAssay Description:Inhibition of FITC-Ahx-Bim-OH binding to human Bcl2 isoform 2 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
LigandPNGBDBM50314865(CHEMBL4172616)
Affinity DataKi:  110nMAssay Description:Inhibition of FITC-Ahx-Bid-OH binding to mouse DN150/DC25 Mcl-1 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630084(CHEMBL5394654)
Affinity DataKi:  119nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Institut De Chimie Des Substances Naturelles (Icsn)

Curated by ChEMBL
LigandPNGBDBM50314865(CHEMBL4172616)
Affinity DataKi:  150nMAssay Description:Inhibition of FITC-AhxBak-OH binding to human 45-84/C37 Bcl-xL after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630087(CHEMBL5417439)
Affinity DataKi:  254nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50541325(CHEMBL4644062)
Affinity DataKi:  300nMAssay Description:Inhibition of Bcl2 (unknown origin)/Bim interaction preincubated for 5 mins followed by fluorescein-labeled peptide addition and measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50314860(CHEMBL4161200)
Affinity DataKi:  340nMAssay Description:Inhibition of FITC-Ahx-Bid-OH binding to mouse DN150/DC25 Mcl-1 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50314860(CHEMBL4161200)
Affinity DataKi:  370nMAssay Description:Inhibition of FITC-Ahx-Bim-OH binding to human Bcl2 isoform 2 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630086(CHEBI:66438 | Schweinfurthin H | SCHWEINFURTHIN H)
Affinity DataKi:  401nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50314863(CHEMBL4162253)
Affinity DataKi:  450nMAssay Description:Inhibition of FITC-Ahx-Bim-OH binding to human Bcl2 isoform 2 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
LigandPNGBDBM50314859(CHEMBL4169123)
Affinity DataKi:  460nMAssay Description:Inhibition of FITC-Ahx-Bid-OH binding to mouse DN150/DC25 Mcl-1 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
LigandPNGBDBM50314864(CHEMBL4172927)
Affinity DataKi:  460nMAssay Description:Inhibition of FITC-Ahx-Bid-OH binding to mouse DN150/DC25 Mcl-1 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
LigandPNGBDBM50314863(CHEMBL4162253)
Affinity DataKi:  490nMAssay Description:Inhibition of FITC-Ahx-Bid-OH binding to mouse DN150/DC25 Mcl-1 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Institut De Chimie Des Substances Naturelles (Icsn)

Curated by ChEMBL
LigandPNGBDBM50314863(CHEMBL4162253)
Affinity DataKi:  510nMAssay Description:Inhibition of FITC-AhxBak-OH binding to human 45-84/C37 Bcl-xL after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630081(CHEMBL5409120)
Affinity DataKi:  523nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50315690(CHEMBL4177447)
Affinity DataKi:  560nMAssay Description:Inhibition of FITC-Ahx-Bid-OH binding to mouse DN150/DC25 Mcl-1 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50541331(CHEMBL4636501)
Affinity DataKi:  600nMAssay Description:Inhibition of Bcl2 (unknown origin)/Bim interaction preincubated for 5 mins followed by fluorescein-labeled peptide addition and measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50314873(CHEMBL4174087)
Affinity DataKi:  620nMAssay Description:Inhibition of FITC-Ahx-Bim-OH binding to human Bcl2 isoform 2 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50314874(CHEMBL4176611)
Affinity DataKi:  700nMAssay Description:Inhibition of FITC-Ahx-Bim-OH binding to human Bcl2 isoform 2 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50541332(CHEMBL4635324)
Affinity DataKi:  700nMAssay Description:Inhibition of Bcl2 (unknown origin)/Bim interaction preincubated for 5 mins followed by fluorescein-labeled peptide addition and measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50314870(CHEMBL4160019)
Affinity DataKi:  740nMAssay Description:Inhibition of FITC-Ahx-Bid-OH binding to mouse DN150/DC25 Mcl-1 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630082(CHEMBL5433829)
Affinity DataKi:  829nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50314859(CHEMBL4169123)
Affinity DataKi:  830nMAssay Description:Inhibition of FITC-Ahx-Bim-OH binding to human Bcl2 isoform 2 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Institut De Chimie Des Substances Naturelles (Icsn)

Curated by ChEMBL
LigandPNGBDBM50314860(CHEMBL4161200)
Affinity DataKi:  840nMAssay Description:Inhibition of FITC-AhxBak-OH binding to human 45-84/C37 Bcl-xL after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50541325(CHEMBL4644062)
Affinity DataKi:  900nMAssay Description:Inhibition of Mcl-1 (unknown origin)/Bid interaction preincubated for 5 mins followed by fluorescein-labeled peptide addition and measured after 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50314874(CHEMBL4176611)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of FITC-Ahx-Bid-OH binding to mouse DN150/DC25 Mcl-1 after 2 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details Article
PubMed
TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM708865((7aR*,9R*,11aR*)-6,9- bis(methoxymethoxy)-8,8,11a-...)
Affinity DataKi:  1.05E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM708869((7aS,9S,11aS)-9-hydroxy-6- (methoxymethoxy)-8,8,11...)
Affinity DataKi:  1.05E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetOxysterol-binding protein 1(Homo sapiens)
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50630085(CHEMBL5399392)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of human C-terminal 6-His tagged OSBP ORD domain (401 to 807 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
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