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TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50217439(cis-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]ben...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620382(CHEMBL5411340)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620379(CHEMBL5438483)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620380(CHEMBL5405712)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620384(CHEMBL5426753)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620386(CHEMBL5420193)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624927(CHEMBL5398068)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624931(CHEMBL5421129)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620368(CHEMBL5408127)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50191854(N-(1-acetyl-piperidin-4-yl)-N'-(adamantan-1-yl)ure...)
Affinity DataIC50: 8nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624929(CHEMBL5395696)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624928(CHEMBL5413117)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624930(CHEMBL5401317)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620374(CHEMBL5415470)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620381(CHEMBL5395369)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620383(CHEMBL5407621)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620370(CHEMBL5435336)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620372(CHEMBL5428089)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620387(CHEMBL5418650)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624922(CHEMBL5418840)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624923(CHEMBL5413658)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620369(CHEMBL5410246)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620378(CHEMBL5411642)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620385(CHEMBL5406849)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50231998(CHEMBL4085835)
Affinity DataIC50: 28nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of A23187-induced product formation using arachidonic acid as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50078888(CHEMBL3416359)
Affinity DataIC50: 29nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624926(CHEMBL5425532)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50231999(CHEMBL4103758)
Affinity DataIC50: 30nMAssay Description:Inhibition of 5-LOX in human PMNL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50231991(CHEMBL4093584)
Affinity DataIC50: 30nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophils assessed as inhibition of A23187-induced product formation using arachidonic acid as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620375(CHEMBL5411847)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50576500(CHEMBL4847874)
Affinity DataIC50: 40nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in 5-LOX product formation preincubated for 10 mins before addition of AA and A23187 and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624925(CHEMBL5441068)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50078886(CHEMBL3416361)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50078890(CHEMBL3416357)
Affinity DataIC50: 40nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50576502(CHEMBL3092679)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in 5-LOX product formation preincubated for 10 mins before addition of AA and A23187 and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50576500(CHEMBL4847874)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in 5-LOX product formation preincubated for 10 mins before addition of A23187 and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50624921(4-Phenylcatechol | CHEMBL475398)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins w...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50078887(CHEMBL3416360)
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50620371(CHEMBL5439306)
Affinity DataIC50: 53nMAssay Description:Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50527521(CHEMBL4463788)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human 5-LOX expressed in Escherichia coli BL21 (DE3) cells preincubated for 10 mins followed by arachidonic acid addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50: 60nMAssay Description:Inhibition of human 5-LOX by cell free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50078889(CHEMBL3416358)
Affinity DataIC50: 60nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50231998(CHEMBL4085835)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2019
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50591532(CHEMBL4590950)
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50591532(CHEMBL4590950)
Affinity DataIC50: 61nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50152151(CHEMBL3781006)
Affinity DataIC50: 65nMAssay Description:Inhibition of 5-LOX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM153384(4-(4-fluorophenyl)-7-[[[5-[(2S)-1,1,1-trifluoro-2-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of 5-LOX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Sannio

Curated by ChEMBL
LigandPNGBDBM50369677(CHEMBL4172824)
Affinity DataIC50: 65nMAssay Description:Inhibition of 5-LOX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM25737(12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid...)
Affinity DataIC50: 69nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
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