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LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  501nMAssay Description:Binding affinity to PI3Kgamma in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  158nMAssay Description:Binding affinity to PI3Kalpha in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  50nMAssay Description:Binding affinity to PI3Kbeta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  2.51E+3nMAssay Description:Binding affinity to PI3Kgamma in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  158nMAssay Description:Binding affinity to PI3Kbeta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  63nMAssay Description:Binding affinity to VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  2nMAssay Description:Binding affinity to VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  316nMAssay Description:Binding affinity to PI3Kalpha in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  0.251nMAssay Description:Binding affinity to PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50543032(CHEMBL4645570)
Affinity DataKd:  251nMAssay Description:Binding affinity to PI3Kdelta (unknown origin) by SPR based van't Hoff analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50543037(CHEMBL4638471)
Affinity DataKd:  4nMAssay Description:Binding affinity to PI3Kdelta (unknown origin) by SPR based van't Hoff analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50573153(CHEMBL4877995)
Affinity DataIC50: 0nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573157(CHEMBL4850297)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573166(CHEMBL4869783)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585507(CHEMBL5078141)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585516(CHEMBL5075673)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585519(CHEMBL5075556)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506311(CHEMBL4462123)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573177(CHEMBL4167702)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573181(CHEMBL4165185)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573182(CHEMBL4175571)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585501(CHEMBL5084542)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585505(CHEMBL5078647)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573180(CHEMBL4175737)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585509(CHEMBL5085176)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50131810(CHEMBL3634602)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573164(CHEMBL4873390)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573174(CHEMBL4868232)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573175(CHEMBL4169192)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585502(CHEMBL5082928)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585504(CHEMBL5084340)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50585508(CHEMBL5079248)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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