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TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at room temperature by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  8.10nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  6nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.490nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 37 degC by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 4 degC by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195700(CHEMBL3975893)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50542080(CHEMBL4649390)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of LysoPLD activity of ATX in human plasma assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195694(CHEMBL3976876)
Affinity DataIC50: 5.90nMAssay Description:Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50542079(CHEMBL4647102)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of LysoPLD activity of ATX in human plasma assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM232964(US9353113, Ref. Ex. 2)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of LysoPLD activity of ATX in human plasma assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542078(CHEMBL4634704)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of LysoPLD activity of ATX in human plasma assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542077(CHEMBL4634102)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of LysoPLD activity of ATX in human plasma assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542077(CHEMBL4634102)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542080(CHEMBL4649390)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12576(JMC515594 Compound 64 | Risdronate | CHEMBL923 | R...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50542078(CHEMBL4634704)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542079(CHEMBL4647102)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285789(CHEMBL4169559)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
LigandPNGBDBM232964(US9353113, Ref. Ex. 2)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195690(CHEMBL3917128)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50542075(CHEMBL4634540)
Affinity DataIC50: 16nMAssay Description:Inhibition of LysoPLD activity of ATX in human plasma assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542070(CHEMBL4634784)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542074(CHEMBL4642470)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542075(CHEMBL4634540)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12577({1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonoprop...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285788(CHEMBL4162680)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50542076(CHEMBL4643803)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285787(CHEMBL4170604)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50542069(CHEMBL4649090)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542076(CHEMBL4643803)
Affinity DataIC50: 25nMAssay Description:Inhibition of LysoPLD activity of ATX in human plasma assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542072(CHEMBL4645794)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285780(CHEMBL4164105)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50542073(CHEMBL4639112)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285781(CHEMBL4165714)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285790(CHEMBL4169137)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285936(CHEMBL4172946)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285935(CHEMBL4171981)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285783(CHEMBL4162273)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195693(CHEMBL3947597)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285786(CHEMBL4175424)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
LigandPNGBDBM325558(6-[9-(3-fluorobenzyl)-5,6,8,9-tetrahydro-7H-pyrido...)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human ATX assessed as reduction in choline release using LPC(16:0) as substrate incubated for 15 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25313((4-amino-1-hydroxy-1-phosphonobutyl)phosphonic aci...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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