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TargetD(3) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50454212(CHEBI:64217 | Emonapride | Nemonapride)
Affinity DataKi:  0.160nMAssay Description:Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50454212(CHEBI:64217 | Emonapride | Nemonapride)
Affinity DataKi:  0.160nMAssay Description:Binding affinity to rat Dopamine receptor D2 expressesd in CHO cells was determined using [125 I ] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50108498(Biphenyl-2-carboxylic acid (4-{5-[2-(4-dimethylami...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity at Vasopressin V1a receptor, performed using [3H]-AVP on rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375457(CHEMBL261476)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375451(CHEMBL408579)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052196(CHEMBL319597 | N-((S)-1-Bicyclo[3.3.1]non-9-yl-pyr...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Astellas Pharma

LigandPNGBDBM35709(YM-35278)
Affinity DataKi:  0.400nM ΔG°:  -53.3kJ/molepH: 7.4 T: 23°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375452(CHEMBL262092)
Affinity DataKi:  0.510nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114031((2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4...)
Affinity DataKi:  0.530nMAssay Description:Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]-AVP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052194(4-Amino-N-((R)-1-benzyl-pyrrolidin-3-yl)-5-chloro-...)
Affinity DataKi:  0.550nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052191(4-Amino-N-((S)-1-benzyl-pyrrolidin-3-yl)-5-chloro-...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50108498(Biphenyl-2-carboxylic acid (4-{5-[2-(4-dimethylami...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]-AVP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052196(CHEMBL319597 | N-((S)-1-Bicyclo[3.3.1]non-9-yl-pyr...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Astellas Pharma

LigandPNGBDBM50108498(Biphenyl-2-carboxylic acid (4-{5-[2-(4-dimethylami...)
Affinity DataKi:  0.770nMAssay Description:Binding affinity at Vasopressin V2 receptor, performed using [3H]-AVP on rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375451(CHEMBL408579)
Affinity DataKi:  0.780nMAssay Description:Displacement of [3H]5-HT from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375457(CHEMBL261476)
Affinity DataKi:  0.780nMAssay Description:Displacement of [3H]5-HT from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052196(CHEMBL319597 | N-((S)-1-Bicyclo[3.3.1]non-9-yl-pyr...)
Affinity DataKi:  0.810nMAssay Description:Binding affinity to rat Dopamine receptor D2 expressesd in CHO cells was determined using [125 I ] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375450(CHEMBL407909 | YM-348)
Affinity DataKi:  0.890nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375450(CHEMBL407909 | YM-348)
Affinity DataKi:  0.890nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052191(4-Amino-N-((S)-1-benzyl-pyrrolidin-3-yl)-5-chloro-...)
Affinity DataKi:  0.980nMAssay Description:Binding affinity to rat Dopamine receptor D2 expressesd in CHO cells was determined using [125 I ] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114033(CHEMBL86667 | {4-[2-(3-Biphenyl-4-yl-5-methyl-[1,2...)
Affinity DataKi:  1.01nMAssay Description:Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]-AVP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114028(1-{6-[2-(3-Biphenyl-4-yl-5-methyl-[1,2,4]triazol-4...)
Affinity DataKi:  1.04nMAssay Description:Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]-AVP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114034(1'-{6-[2-(3-Biphenyl-4-yl-5-methyl-[1,2,4]triazol-...)
Affinity DataKi:  1.05nMAssay Description:Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]-AVP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052191(4-Amino-N-((S)-1-benzyl-pyrrolidin-3-yl)-5-chloro-...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to rat Dopamine receptor D2 expressesd in CHO cells was determined using [125 I ] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50108498(Biphenyl-2-carboxylic acid (4-{5-[2-(4-dimethylami...)
Affinity DataKi:  1.19nMAssay Description:Binding affinity at cloned human Vasopressin V2 receptor stably expressed in CHO cells, using [3H]-AVP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052194(4-Amino-N-((R)-1-benzyl-pyrrolidin-3-yl)-5-chloro-...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to rat Dopamine receptor D2 expressesd in CHO cells was determined using [125 I ] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052186(4-Acryloylamino-N-((S)-1-benzyl-pyrrolidin-3-yl)-5...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375458(CHEMBL406851)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114031((2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4...)
Affinity DataKi:  1.43nMAssay Description:Binding affinity at Vasopressin V1a receptor, performed using [3H]-AVP on rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052184(5-Chloro-N-((S)-1-cycloheptyl-pyrrolidin-3-yl)-4-(...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052195(CHEMBL93198 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-c...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052181(CHEMBL92924 | N-((S)-1-Adamantan-2-yl-pyrrolidin-3...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052194(4-Amino-N-((R)-1-benzyl-pyrrolidin-3-yl)-5-chloro-...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052182(CHEMBL330318 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  2.10nMAssay Description:Compound was tested for the binding affinity against rat cortical Muscarinic acetylcholine receptor M1 by radioligand [3H]-pirenzepine binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052199(5-Chloro-N-((S)-1-cyclohexyl-pyrrolidin-3-yl)-4-(c...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052180(CHEMBL328866 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114025(4-{4-[2-(3-Biphenyl-4-yl-5-methyl-[1,2,4]triazol-4...)
Affinity DataKi:  2.12nMAssay Description:Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]-AVP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rat)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052183(CHEMBL94050 | N-((S)-1-Bicyclo[3.3.1]non-9-yl-pyrr...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375900(CHEMBL259480)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375450(CHEMBL407909 | YM-348)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375454(CHEMBL261045)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052184(5-Chloro-N-((S)-1-cycloheptyl-pyrrolidin-3-yl)-4-(...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50375447(CHEMBL403927)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052179(CHEMBL93021 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-5-c...)
Affinity DataKi:  3nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50114032(CHEMBL86577 | {4-[2-(3-Biphenyl-4-yl-5-methyl-[1,2...)
Affinity DataKi:  3.03nMAssay Description:Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]-AVP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052197(5-Chloro-N-((S)-1-cyclohexylmethyl-pyrrolidin-3-yl...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35683(5H-1-benzazepin-5-ylidene acetamide, 1k)
Affinity DataKi:  3.40nM ΔG°:  -48.0kJ/molepH: 7.4 T: 23°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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