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TargetAldo-keto reductase family 1 member B1(Human)
University of Marburg

LigandPNGBDBM16249(2-[(4-methyl-3,5,5-trioxo-5-thia-4-azatricyclo[7.4...)
Affinity DatapH: 6.2 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the oxidation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2007
Entry Details Article
PubMed
TargetAdenosine deaminase(Bovine)
Universita Di Pisa

LigandPNGBDBM28377(2-nonyl-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one | ...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2009
Entry Details Article
PubMed
TargetAdenosine deaminase(Bovine)
Universita Di Pisa

LigandPNGBDBM28378(2-decyl-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one | ...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2009
Entry Details Article
PubMed
TargetAdenosine deaminase(Bovine)
Universita Di Pisa

LigandPNGBDBM28379(2-undecyl-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one ...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of recombinant human PDGFRbeta expressed in insect cells using Ulight-Poly GAT[EAY(1:1:1)]n as substrate after 30 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50292729((7R,8R)-N-(3-iodophenyl)-7,8-bis(methoxymethyl)-7,...)
Affinity DataIC50: 1.66nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM4567(CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazol...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human KDR expressed in Sf9 insect cells using Ulight-CAGAGAIETDKEYYTVKD as substrate after 60 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human c-KIT using Ulight-TK peptide as substrate after 30 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human Flt4 using Ulight-CAGAGAIETDKEYYTVKD as substrate after 90 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human PDGFRbeta by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50102093(6,7-dimethoxy-N-m-tolylquinazolin-4-amine | (6,7-D...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human CDK1 by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human Src expressed in insect cells using Ulight-Poly GAT[EAY(1:1:1)]n as substrate after 10 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50292731((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM4568(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dim...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50292732((R)-N-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50292734((S)-2-(((4-(3-chloro-4-fluorophenylamino)-7-methox...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM4566(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-y...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50292730(N-(4-(3-bromophenylamino)-1,7-naphthyridin-6-yl)-4...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50292733((R)-2-(((4-(3-chloro-4-fluorophenylamino)-7-methox...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human Src kinase by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50292728((7R,8R)-N-(3-chlorophenyl)-7,8-bis(methoxymethyl)-...)
Affinity DataIC50: 10.1nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human AurA kinase by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Akt1 by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human ROCK1 by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR (unknown origin) using omnia tyr peptide 7 substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human MEK1 by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human CDK1/Cyclin B expressed in insect cells using Ulight-CFFKNIVTPRTPPPSQGK-amide as substrate after 15 mins by LANCE met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 29nMAssay Description:Inhibition of Sprague-Dawley rat kidney ALR1 using sodium D-glucuronate as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human Flt1 expressed in Sf9 insect cells using Ulight-TK peptide as substrate after 15 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human Aurora-A expressed in Sf21 insect cells using Ulight-RRRSLLE as substrate after 15 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 50nMAssay Description:Inhibition of Sprague-Dawley rat kidney ALR1 using sodium D-glucuronate as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFocal adhesion kinase 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human FAK by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human AKT1 expressed in insect cells using CREBtide as substrate after 60 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant human FAK expressed in Sf9 insect cells using Ulight-TK peptide as substrate after 60 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50334175(2-(2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Affinity DataIC50: 70nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human RAF1 by kinase inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
University of Marburg

LigandPNGBDBM16240(2-(carboxymethyl)-1-oxo-1,2-dihydronaphtho[1,2-d]i...)
Affinity DataIC50: 140nMpH: 6.2 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the oxidation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human IGF1R using Ulight-TK peptide as substrate after 60 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Sprague-Dawley albino rat ALR2 assessed as enzyme-mediated oxidation of NADPH using D,L-glyceraldehyde as substrate by spectrophotometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Sprague-Dawley albino rat lens ALR2 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50346849(CHEMBL1796882)
Affinity DataIC50: 250nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50346847(CHEMBL1796755)
Affinity DataIC50: 270nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant human ABL expressed in insect cells using Ulight-TK peptide as substrate after 60 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50346854(CHEMBL1796887)
Affinity DataIC50: 300nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant human c-MET expressed in insect cells using Ulight-CAGAGAIETDKEYYTVKD as substrate after 60 mins by LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
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