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TargetNuclear factor erythroid 2-related factor 2(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50067028((1E,4E)-1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta...)
Affinity DataEC50:  900nMAssay Description:Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinoneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020585(CHEMBL3290186)
Affinity DataEC50:  3.10E+3nMAssay Description:Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinoneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020587(CHEMBL3290185)
Affinity DataEC50:  8.60E+3nMAssay Description:Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinoneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50067040(CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...)
Affinity DataEC50:  9.90E+3nMAssay Description:Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinoneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492037(CHEMBL2391055)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50361590(CHEMBL1939677)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50142932(CHEMBL3759842)
Affinity DataIC50: 7nMAssay Description:Inhibition of COX-2 in mouse J774 cells assessed as reduction in LPS-induced PGE2 level incubated for 24 hrs by radio immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50308732(Isopropyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50361584(CHEMBL1939671)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492043(CHEMBL2391047)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50224118(ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50224129(ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[4-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50517099(CHEMBL4563969)
Affinity DataIC50: 11nMAssay Description:Inhibition of COX-2 in LPS-induced mouse J774 cells assessed as inhibition of PEG2 production after 24 hrs by radioimmuno assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 12nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50492035(CHEMBL2391054)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50361581(CHEMBL1939667)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020584(CHEMBL2413471)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020584(CHEMBL2413471)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020584(CHEMBL2413471)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM22334(N-(3-phenoxycinnamyl)acetohydroxamic acid | BW A4C...)
Affinity DataIC50: 13nMAssay Description:Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of mPGES1-mediated PGE2 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX1-mediated PGF2alpha formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX1-mediated PGD2 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX2-mediated PGF2alpha formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX2-mediated PGD2 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50020589(CHEMBL3290441)
Affinity DataIC50: 13nMAssay Description:Inhibition of 15-LO-mediated 15-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50142935(CHEMBL3759195)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX-2 in mouse J774 cells assessed as reduction in LPS-induced PGE2 level incubated for 24 hrs by radio immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50142937(CHEMBL3759726)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX-2 in mouse J774 cells assessed as reduction in LPS-induced PGE2 level incubated for 24 hrs by radio immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50517095(CHEMBL4535137)
Affinity DataIC50: 14nMAssay Description:Inhibition of COX-2 in LPS-induced mouse J774 cells assessed as inhibition of PEG2 production after 24 hrs by radioimmuno assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50308736(n-Butyl-2-Methyl-5-[4-(methylsulfonyl)phenyl]-1-ph...)
Affinity DataIC50: 14nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50430948(CHEMBL2337402)
Affinity DataIC50: 14nMAssay Description:Inhibition of Escherichia coli lipopolysaccharide-induced COX2 activity in mouse J774 cells assessed as decrease in PGE2 levels after 24 hrs by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50262934([3-(2-Ethoxyethyl)-2-methyl-5-(4-methylsulphonyl)p...)
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50430957(CHEMBL2337404)
Affinity DataIC50: 15nMAssay Description:Inhibition of Escherichia coli lipopolysaccharide-induced COX2 activity in mouse J774 cells assessed as decrease in PGE2 levels after 24 hrs by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50361587(CHEMBL1939674)
Affinity DataIC50: 17nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50430960(CHEMBL2337400)
Affinity DataIC50: 17nMAssay Description:Inhibition of Escherichia coli lipopolysaccharide-induced COX2 activity in mouse J774 cells assessed as decrease in PGE2 levels after 24 hrs by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50262990([2-Methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(...)
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50262933([1-(4-Fluoro)phenyl-2-methyl-5-(4-methylsulphonyl)...)
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50142936(CHEMBL3758384)
Affinity DataIC50: 18nMAssay Description:Inhibition of COX-2 in mouse J774 cells assessed as reduction in LPS-induced PGE2 level incubated for 24 hrs by radio immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50361578(CHEMBL1939670)
Affinity DataIC50: 19nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50142930(CHEMBL3759435)
Affinity DataIC50: 19nMAssay Description:Inhibition of COX-2 in mouse J774 cells assessed as reduction in LPS-induced PGE2 level incubated for 24 hrs by radio immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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