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TargetEndothelin-1 receptor(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50101257((1R,2S,3R)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  0.430nMAssay Description:Tested for in vitro inhibition of [125I]-ET-1 binding to CHO cells expressing human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin receptor type B(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50101257((1R,2S,3R)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  15nMAssay Description:Inhibition of [125I]-ET-1 binding to CHO cells expressing human Endothelin B receptor at a concentration of 1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291559(CHEMBL268473 | {2-Benzo[1,3]dioxol-5-yl-1-[(S)-2-b...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291555(CHEMBL276690 | {2-Benzo[1,3]dioxol-4-yl-1-[(S)-2-b...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291558(CHEMBL276872 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291557(CHEMBL268761 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291556(CHEMBL273489 | {2-Benzo[1,3]dioxol-5-yl-1-[(R)-2-b...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084905(CHEMBL147964 | {1-[2-Dibenzofuran-3-yl-1-(1H-tetra...)
Affinity DataIC50:  2.60nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084905(CHEMBL147964 | {1-[2-Dibenzofuran-3-yl-1-(1H-tetra...)
Affinity DataIC50:  2.60nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084897(3-Dibenzofuran-3-yl-2-[3-dibenzofuran-3-yl-2-(phos...)
Affinity DataIC50:  2.70nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-1 receptor(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50101268(CHEMBL50232 | [(1R,3R)-1-Benzo[1,3]dioxol-5-yl-3-(...)
Affinity DataIC50:  4.10nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to CHO cells expressing recombinant human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVitamin K epoxide reductase complex subunit 1(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50535485(CHEMBL4594145)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePDB3D3D Structure (crystal)

TargetNeprilysin(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291561(CHEMBL10251 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetraz...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50064109(CGS-31447 | CHEMBL285619 | {1-[(S)-2-Biphenyl-4-yl...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064109(CGS-31447 | CHEMBL285619 | {1-[(S)-2-Biphenyl-4-yl...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-1 receptor(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50101258(CHEMBL295440 | [(1R,3S)-1-Benzo[1,3]dioxol-5-yl-3-...)
Affinity DataIC50:  5.40nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to CHO cells expressing recombinant human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084903(CHEMBL148056 | {[2-Dibenzofuran-3-yl-1-(1H-tetrazo...)
Affinity DataIC50:  6nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-1 receptor(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50101271(CHEMBL47868 | [(1R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(...)
Affinity DataIC50:  6.10nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to CHO cells expressing recombinant human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084897(3-Dibenzofuran-3-yl-2-[3-dibenzofuran-3-yl-2-(phos...)
Affinity DataIC50:  6.40nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50159369(CGS-31,4447 | CHEMBL415967 | {1-[(S)-2-Biphenyl-4-...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064110(2-{2-[(S)-5-(2,4-Difluoro-phenyl)-2-(phosphonometh...)
Affinity DataIC50:  8nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291562(CHEMBL9963 | {1-[(R)-2-Biphenyl-4-yl-1-(1H-tetrazo...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetVitamin K epoxide reductase complex subunit 1(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50119751(2-{[1-(2-Mercapto-4-methyl-pentanoylamino)-cyclope...)
Affinity DataIC50:  9.5nMAssay Description:In vitro inhibition of Endothelin-converting enzyme 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50119742(2-{[1-(2-Mercapto-4-methyl-pentanoylamino)-cyclope...)
Affinity DataIC50:  9.80nMAssay Description:In vitro inhibition of Endothelin-converting enzyme 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50091882((S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-1-oxo-pe...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity was tested against Endothelin converting enzyme 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50091882((S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-1-oxo-pe...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of human Endothelin converting Enzyme-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50091878((S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-3-methox...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of human Endothelin converting Enzyme-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50091882((S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-1-oxo-pe...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of Endothelin-converting enzyme 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-1 receptor(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50101259(CHEMBL298212 | [(1R,3S)-1-Benzo[1,3]dioxol-5-yl-3-...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to CHO cells expressing recombinant human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084895(2-[(S)-3-Dibenzofuran-3-yl-2-(phosphonomethyl-amin...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064114((S)-3-Biphenyl-4-yl-2-[(S)-5-(2-fluoro-phenyl)-2-(...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084898(2-[3-Dibenzofuran-3-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  13nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064125((S)-3-Cyclohexyl-2-[(S)-5-(2,4-difluoro-phenyl)-2-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-1 receptor(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50101262(3-[2-((1R,3R)-3-Benzo[1,3]dioxol-5-yl-2-carboxymet...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to CHO cells expressing recombinant human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Rat)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064096(CHEMBL40028 | {[(S)-4-(2-Fluoro-phenyl)-1-(2H-tetr...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50064096(CHEMBL40028 | {[(S)-4-(2-Fluoro-phenyl)-1-(2H-tetr...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064109(CGS-31447 | CHEMBL285619 | {1-[(S)-2-Biphenyl-4-yl...)
Affinity DataIC50:  17nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064109(CGS-31447 | CHEMBL285619 | {1-[(S)-2-Biphenyl-4-yl...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeprilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291564(CHEMBL418704 | {1-[(R)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  17nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50291561(CHEMBL10251 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetraz...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition against recombinant human Endothelin converting enzyme 1 activityMore data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50091888((S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-4-methyl...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of human Endothelin converting Enzyme-1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-1 receptor(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50101275(4-[2-((1S,3R)-3-Benzo[1,3]dioxol-5-yl-2-carboxymet...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to CHO cells expressing recombinant human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084893((S)-3-(dibenzo[b,d]furan-3-yl)-2-(phosphonomethyla...)
Affinity DataIC50:  22nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEndothelin-converting enzyme 1(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50084892(3-Dibenzofuran-3-yl-2-[1-phosphono-3-(3,4,5-trimet...)
Affinity DataIC50:  22nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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