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TargetSuppressor of tumorigenicity 14 protein(Human)
Johannes Gutenberg-University Staudingerweg

Curated by ChEMBL
LigandPNGBDBM50615190(CHEMBL5269464)
Affinity DataKd:  637nMAssay Description:Binding affinity to recombinant hexahistidine tagged human MT-SP1 (596 to 855 residues) expressed in Escherichia coli BL21 gold (DE3) cells using Boc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Johannes Gutenberg-University Staudingerweg

Curated by ChEMBL
LigandPNGBDBM50615189(CHEMBL5279198)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to recombinant hexahistidine tagged human MT-SP1 (596 to 855 residues) expressed in Escherichia coli BL21 gold (DE3) cells using Boc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Johannes Gutenberg-University Staudingerweg

Curated by ChEMBL
LigandPNGBDBM50615188(CHEMBL5275339)
Affinity DataKd:  2.52E+3nMAssay Description:Binding affinity to recombinant hexahistidine tagged human MT-SP1 (596 to 855 residues) expressed in Escherichia coli BL21 gold (DE3) cells using Boc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Johannes Gutenberg-University Staudingerweg

Curated by ChEMBL
LigandPNGBDBM50615187(CHEMBL5289898)
Affinity DataKd:  1.02E+4nMAssay Description:Binding affinity to recombinant hexahistidine tagged human MT-SP1 (596 to 855 residues) expressed in Escherichia coli BL21 gold (DE3) cells using Boc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Johannes Gutenberg-University Staudingerweg

Curated by ChEMBL
LigandPNGBDBM50615186(CHEMBL5282514)
Affinity DataKd:  392nMAssay Description:Binding affinity to recombinant hexahistidine tagged human MT-SP1 (596 to 855 residues) expressed in Escherichia coli BL21 gold (DE3) cells using Boc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Johannes Gutenberg-University Staudingerweg

Curated by ChEMBL
LigandPNGBDBM50615185(CHEMBL5265971)
Affinity DataKd:  1.45E+3nMAssay Description:Binding affinity to recombinant hexahistidine tagged human MT-SP1 (596 to 855 residues) expressed in Escherichia coli BL21 gold (DE3) cells using Boc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316497(N-{4-[1-(2,3-Dihydroxypropyl)-4-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 1nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316473(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316475(N-Ethyl-N'-[4-(1-ethyl-4-{2-[4-(1-pyrrolidinylmeth...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316471(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316492(1-(4-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316498(N-{4-[1-(3-Hydroxypropyl)-4-(1H-pyrrolo[2,3-b]pyri...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50091691(CHEMBL3582356)
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316474(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132G](Human)
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11376246, Cpd ID GSK321 | US11576906, C...)
Affinity DataIC50: 2.90nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316496(N-{4-[1-(2-Hydroxyethyl)-4-(1H-pyrrolo[2,3-b]pyrid...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316470(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316472(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Human)
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11376246, Cpd ID GSK321 | US11576906, C...)
Affinity DataIC50: 3.80nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091692(CHEMBL3582357)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316476(N'-[4-(1-Ethyl-4-{2-[4-(1-pyrrolidinylmethyl)pheny...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11376246, Cpd ID GSK321 | US11576906, C...)
Affinity DataIC50: 4.60nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316479((4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316478(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316483(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316481(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316477(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataIC50: 6.5nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316482(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316480(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316509(4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50: 11nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091691(CHEMBL3582356)
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316495(N-Phenyl-N'-{4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50091694(CHEMBL3582359)
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50091694(CHEMBL3582359)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 17nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
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