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TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nM ΔG°:  -50.5kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50100949((7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-meth...)
Affinity DataKi:  12nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50077544((S)-3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoli...)
Affinity DataKi:  16nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50174121(7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline | ...)
Affinity DataKi:  17nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13027(3-(hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4...)
Affinity DataKi:  23nM ΔG°:  -45.4kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50077537((+)-(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)me...)
Affinity DataKi:  47nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13023(3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7...)
Affinity DataKi:  52nM ΔG°:  -43.2kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50072977(7-Bromo-1,2,3,4-tetrahydro-isoquinoline | 7-bromo-...)
Affinity DataKi:  56nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50072977(7-Bromo-1,2,3,4-tetrahydro-isoquinoline | 7-bromo-...)
Affinity DataKi:  56nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13025(7-sulfonamide-THIQ 15 | CHEMBL176112 | N-(4-chloro...)
Affinity DataKi:  63nM ΔG°:  -42.8kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50186678((+/-)-3-difluoromethyl-7-trifluoromethyl-1,2,3,4-t...)
Affinity DataKi:  67nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50227503(3-Methyl-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-c...)
Affinity DataKi:  67nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50077543(3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline |...)
Affinity DataKi:  72nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50186676((+/-)-3-difluoromethyl-7-bromo-1,2,3,4-tetrahydroi...)
Affinity DataKi:  94nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50072991(7-Nitro-1,2,3,4-tetrahydro-isoquinoline | 7-nitro-...)
Affinity DataKi:  120nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50072991(7-Nitro-1,2,3,4-tetrahydro-isoquinoline | 7-nitro-...)
Affinity DataKi:  120nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13026(3-(fluoromethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4-...)
Affinity DataKi:  130nM ΔG°:  -40.9kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13022(3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-...)
Affinity DataKi:  150nM ΔG°:  -40.5kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50160906((+/-)-3-difluoromethyl-7-nitro-1,2,3,4-tetrahydroi...)
Affinity DataKi:  170nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50186682((+/-)-3-difluoromethyl-7-iodo-1,2,3,4-tetrahydrois...)
Affinity DataKi:  200nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50199508(7-bromo-1,2,3,4-tetrahydrobenzo[h]isoquinoline | C...)
Affinity DataKi:  220nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13028(3-(fluoromethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4...)
Affinity DataKi:  220nM ΔG°:  -39.5kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50186670((+/-)-3-difluoromethyl-7-(N-2,2,2-trifluoroethylam...)
Affinity DataKi:  250nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13024(7-sulfonamide-THIQ 14 | CHEMBL290890 | N-(4-chloro...)
Affinity DataKi:  270nM ΔG°:  -39.0kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50160902(2-(7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-et...)
Affinity DataKi:  350nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50227499((S)-6-methyl-2-nitro-4,5,6,7-tetrahydrothieno[3,2-...)
Affinity DataKi:  480nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50160904(2-(7-Nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-et...)
Affinity DataKi:  510nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50186677((+/)-7-aminosulfonyl-3-difluoromethyl-1,2,3,4-tetr...)
Affinity DataKi:  680nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50227517(2-bromo-6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]py...)
Affinity DataKi:  730nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13018(7-methanesulfonyl-1,2,3,4-tetrahydroisoquinoline |...)
Affinity DataKi:  790nM ΔG°:  -36.2kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50186668((+/-)-7-(N-4-chlorophenylaminosulfonyl)-3-difluoro...)
Affinity DataKi:  900nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50199511(7-nitro-1,2,3,4-tetrahydrobenzo[h]isoquinoline | C...)
Affinity DataKi:  900nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50199512(1,2,3,4-tetrahydrobenzo[h]isoquinolin-7-ol | CHEMB...)
Affinity DataKi:  910nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13041(3-(fluoromethyl)-7-methanesulfonyl-1,2,3,4-tetrahy...)
Affinity DataKi:  1.10E+3nM ΔG°:  -35.4kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50227502(2-bromo-3a,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridi...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13034(((+/-)-3-Fluoromethyl-7-(3,3,3-trifluoropropylsulf...)
Affinity DataKi:  1.30E+3nM ΔG°:  -34.9kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50160905(3-(7-Nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-pr...)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13030(7-sulfonamide-THIQ 20 | CHEMBL177861 | N-ethyl-3-(...)
Affinity DataKi:  1.40E+3nM ΔG°:  -34.8kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13040(3-(fluoromethyl)-7-[(2,2,2-trifluoroethane)sulfony...)
Affinity DataKi:  1.40E+3nM ΔG°:  -34.8kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50023304(3-Methyl-1,2,3,4-tetrahydro-isoquinoline | 3-methy...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50072989(1,2,3,4-Tetrahydro-isoquinoline-7-carbonitrile | 1...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity to human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Bovine)
The University of Kansas

Curated by ChEMBL
LigandPNGBDBM50072989(1,2,3,4-Tetrahydro-isoquinoline-7-carbonitrile | 1...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of bovine PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50077538((R)-3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoli...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human PNMT by radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13031(3-(fluoromethyl)-N-propyl-1,2,3,4-tetrahydroisoqui...)
Affinity DataKi:  1.70E+3nM ΔG°:  -34.3kJ/molepH: 8.0 T: 37°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM50160903(3-(7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-pr...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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