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TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50426967(PF-4693627 | CHEMBL2325079)
Affinity DataIC50: 3nMAssay Description:Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 cells microsomes assessed as reduction in PGE2 production preincubated for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001935(CHEMBL3233601)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001936(CHEMBL3233602)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 7nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 7nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001934(CHEMBL3233600)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001936(CHEMBL3233602)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001933(CHEMBL3233599)
Affinity DataIC50: 11nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631789(CHEMBL5431632)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631786(CHEMBL5435139)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631794(CHEMBL5403406)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631795(CHEMBL5432195)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631775(CHEMBL5439775)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631781(CHEMBL5431408)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631784(CHEMBL5402886)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631790(CHEMBL5427380)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631793(CHEMBL5425138)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631780(CHEMBL5395492)
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631776(CHEMBL5401566)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001933(CHEMBL3233599)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631778(CHEMBL5410515)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001935(CHEMBL3233601)
Affinity DataIC50: 53nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569442(CHEMBL4864480)
Affinity DataIC50: 60nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-stimulated PGE2 productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631783(CHEMBL5423836)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50135226(CHEMBL3747473)
Affinity DataIC50: 60nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631796(Enviroxime | Enviroxima | Viroxime component b | Z...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631788(CHEMBL5415642)
Affinity DataIC50: 66nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50135228(CHEMBL3746729)
Affinity DataIC50: 70nMAssay Description:Inhibition of PGES-1 in human A549 cell microsomes using PGH2 as substrate assessed as suppression of interleukin-1beta-stimulated PGE2 production in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631787(CHEMBL5431413)
Affinity DataIC50: 72nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001934(CHEMBL3233600)
Affinity DataIC50: 85nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631773(CHEMBL5396829)
Affinity DataIC50: 94nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569443(CHEMBL4851179)
Affinity DataIC50: 150nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGE2 production incubated for 24 hrs by EIAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569444(CHEMBL4848472)
Affinity DataIC50: 160nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGE2 production incubated for 24 hrs by EIAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631777(CHEMBL5428790)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631779(CHEMBL5411938)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631785(CHEMBL5428664)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569442(CHEMBL4864480)
Affinity DataIC50: 190nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGE2 production incubated for 24 hrs by EIAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631782(CHEMBL5435605)
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569446(CHEMBL4870406)
Affinity DataIC50: 240nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGE2 production incubated for 24 hrs by EIAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569442(CHEMBL4864480)
Affinity DataIC50: 250nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGI2 productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569444(CHEMBL4848472)
Affinity DataIC50: 340nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-stimulated PGE2 productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50001931(CHEMBL3233597)
Affinity DataIC50: 450nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569446(CHEMBL4870406)
Affinity DataIC50: 490nMAssay Description:Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 cells microsomes assessed as reduction in PGE2 production preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | N-benzyl-2-(3-(biphenyl-4-yl)-2-((5...)
Affinity DataIC50: 510nMAssay Description:Inhibition of T type calcium channel Cav3.1 (unknown origin) expressed in HEK293T cells by patch clamp method relative to controlMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50631792(CHEMBL5426813)
Affinity DataIC50: 510nMAssay Description:Inhibition of human recombinant GST tagged P14KIII beta incubated for 10 mins by ADP-Glo kinase methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50426967(PF-4693627 | CHEMBL2325079)
Affinity DataIC50: 520nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGE2 production incubated for 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50197521(CHEMBL3922351)
Affinity DataIC50: 550nMAssay Description:Inhibition of mPGES-1 in mouse RAW264.7 cells assessed as reduction in LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569445(CHEMBL4848316)
Affinity DataIC50: 610nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGE2 production incubated for 24 hrs by EIAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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