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TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at room temperature by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  8.10nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  6nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.490nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 37 degC by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 4 degC by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149710(US8975409, Example 38)
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149709(US8975409, Example 19)
Affinity DataIC50: 1.70nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetThromboxane A2 receptor(Rat)
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50075089(Sodium; [2-(4-chloro-benzenesulfonylamino)-indan-5...)
Affinity DataIC50: 2.20nMAssay Description:In vitro thromboxane A2 antagonistic activity on U-46619 (0.1 uM) induced contraction of rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50: 2.30nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50: 2.5nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149706(US8975409, Example 13)
Affinity DataIC50: 3nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149706(US8975409, Example 13)
Affinity DataIC50: 3nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetThromboxane A2 receptor(Rat)
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50075088(Sodium; {2-[(4-chloro-benzenesulfonylamino)-methyl...)
Affinity DataIC50: 3nMAssay Description:In vitro thromboxane A2 antagonistic activity on U-46619 (0.1 uM) induced contraction of rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50065614(CHEMBL3401386)
Affinity DataIC50: 3nMAssay Description:Displacement of [33P]-S1P from human S1P2 receptor expressed in CHOK1 cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 3.30nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149710(US8975409, Example 38)
Affinity DataIC50: 3.40nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50143197(CHEMBL3759037)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50065611(CHEMBL3401383)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [33P]-S1P from human S1P2 receptor expressed in CHOK1 cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50065611(CHEMBL3401383)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [33P]S1P from human S1P2 expressed in CHO-K1 cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50143192(CHEMBL3758929)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50065610(CHEMBL3401382)
Affinity DataIC50: 4.10nMAssay Description:Displacement of [33P]-S1P from human S1P2 receptor expressed in CHOK1 cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50120582(CHEMBL3618199)
Affinity DataIC50: 4.60nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50065611(CHEMBL3401383)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149708(US8975409, Example 15(6))
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149708(US8975409, Example 15(6))
Affinity DataIC50: 5.10nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149709(US8975409, Example 19)
Affinity DataIC50: 5.20nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50120583(CHEMBL3618200)
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 6.20nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at human S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50143201(CHEMBL3759864)
Affinity DataIC50: 6.40nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149707(US8975409, Example 15(1))
Affinity DataIC50: 7nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50143203(CHEMBL3759434)
Affinity DataIC50: 8.20nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50065615(CHEMBL3401387)
Affinity DataIC50: 8.80nMAssay Description:Displacement of [33P]-S1P from human S1P2 receptor expressed in CHOK1 cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50143202(CHEMBL3758872)
Affinity DataIC50: 8.80nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50143206(CHEMBL3759532)
Affinity DataIC50: 8.80nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50143200(CHEMBL3758775)
Affinity DataIC50: 9.30nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149709(US8975409, Example 19)
Affinity DataIC50: 9.40nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149707(US8975409, Example 15(1))
Affinity DataIC50: 9.60nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
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