Report error Found 504 with Last Name = 'simard' and Initial = 'jr'
TargetMyosin light chain kinase, smooth muscle(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataKi: 3.80E+3nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataKi: 1.10E+5nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 0.0800nMpH: 7.5 T: 23°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 0.220nMpH: 7.5 T: 23°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 0.400nM Kd: 11nMpH: 7.0 T: 23°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 0.400nM Kd: 11nMAssay Description:Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Human)
Technische Universit??????T Dortmund
Technische Universit??????T Dortmund
Affinity DataIC50: 0.400nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturers instructions. The kinases A...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 0.430nMpH: 7.5 T: 23°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Human)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 1.20nMpH: 7.5 T: 23°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Human)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 3nMpH: 7.5 T: 23°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Human)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 3.60nMpH: 7.5 T: 23°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Human)
Technische Universit??????T Dortmund
Technische Universit??????T Dortmund
Affinity DataIC50: 6nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturers instructions. The kinases A...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 6.30nM Kd: 8nMAssay Description:Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminus His-tagged human p38alpha expressed in Escherichia coli BL21 DE3 using GST-tagged ATF2 as substrate after 90 mins by HTRF as...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Human)
Technische Universit??????T Dortmund
Technische Universit??????T Dortmund
Affinity DataIC50: 10nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturers instructions. The kinases A...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 14nM Kd: 56nMpH: 7.0 T: 23°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of DDR2 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 21nM Kd: 73nMpH: 7.0 T: 23°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 23nMpH: 7.0 T: 23°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Human)
Technische Universit??????T Dortmund
Technische Universit??????T Dortmund
Affinity DataIC50: 29nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturers instructions. The kinases A...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Human)
Technische Universit??????T Dortmund
Technische Universit??????T Dortmund
Affinity DataIC50: 33nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturers instructions. The kinases A...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 34nMpH: 7.0 T: 23°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of DDR1 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of DDR2 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Human)
Technical University of Dortmund
Curated by ChEMBL
Technical University of Dortmund
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibition of DDR1 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Chemical Genomics Centre of The Max Planck Society
Chemical Genomics Centre of The Max Planck Society
Affinity DataIC50: 71nM Kd: 174nMpH: 7.0 T: 23°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair