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TargetGenome polyprotein(DENV-2)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50525245(CHEMBL1980535)
Affinity DataEC50:  8.50E+3nMAssay Description:Inhibition of DENV NS2B/NS3 protease transfected in human Huh-7 cells treated for 3 days by nano-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGenome polyprotein(DENV-2)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50588193(CHEMBL586053)
Affinity DataEC50:  4.70E+3nMAssay Description:Inhibition of DENV NS2B/NS3 protease transfected in human Huh-7 cells using 7-amino-4-methylcoumarin (AMC) fluorophore-linked peptide substrate Boc-G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50081711(CHEMBL3421639)
Affinity DataIC50: 0.0430nMAssay Description:Inhibition of human CYP1B1 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM50293306(3-(5-methoxybenzofuran-7-yl)-4-(1-(2-(4-methylpipe...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(DENV-2)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50588195(CHEMBL5188858)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of DENV NS2B/NS3 proMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483581(CHEMBL1689301)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 1A1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50507600(CHEMBL4467401)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP1A1 by EROD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM50150701(7-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-2,5-dihy...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483589(CHEMBL1689302)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM50293307(N-(4-(ethylsulfonamido)phenethyl)-2-(2-chloro-4-fl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50239038(CHEMBL4074105)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483582(CHEMBL1689303)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM3175(Bisindolylmaleimide 11b | Ro 31-8220 | CHEMBL6291 ...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50188337(CHEMBL2058057)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483597(CHEMBL1689304)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50507596(CHEMBL4532099)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human CYP1B1 using 7-Ethoxyresorufin as substrate after 30 mins in presence of NADP+ by EROD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50507598(CHEMBL4539787)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human CYP1B1 using 7-Ethoxyresorufin as substrate after 30 mins in presence of NADP+ by EROD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483583(CHEMBL1689305)
Affinity DataIC50: 4nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli DH5[alpha] using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50239037(CHEMBL4100866)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50507599(CHEMBL4456952)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human CYP1B1 using 7-Ethoxyresorufin as substrate after 30 mins in presence of NADP+ by EROD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM8579(N-[6-(pyridin-3-yl)furo[2,3-d]pyrimidin-4-yl]cyclo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483595(CHEMBL1689306)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM50132317(17,23-dimethyl-20-oxa-4,14,17,23,26-pentaazahexacy...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483584(CHEMBL1689307)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM50293308(3-(2,5-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetYersiniabactin siderophore biosynthetic protein(Yersinia pestis CA88-4125)
Weill Medical College of Cornell University

Curated by ChEMBL
LigandPNGBDBM50324670(5'-O-[N-(salicyl)-sulfamoyl]-adenosine | 5'-O-[N-(...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Yersinia pestis YbtE assessed as incorporation of [3H]salicyl group to HMWP2 proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM7492(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM7491(4-[2-Amino-5-oxo-1,5-dihydro-imidazol-(4Z)-ylidene...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP1A1 expressed in yeast microsomal membranes using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin as substrate by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1A1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50507598(CHEMBL4539787)
Affinity DataIC50: 11nMAssay Description:Inhibition of human CYP1A1 using 7-Ethoxyresorufin as substrate after 15 mins in presence of NADP+ by EROD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4 (S4 to E303 residues)/Cyclin D1 (Q4 to I295 residues) expressed in sf9 cells using RBCTF a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(DENV-2)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50588184(CHEMBL5206054)
Affinity DataIC50: 15nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-7-amino-4-methylcoumarin as substrate preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 16nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein(DENV-2)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50588185(CHEMBL5205657)
Affinity DataIC50: 16nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-7-amino-4-methylcoumarin as substrate preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) using RBER-CHKtide as substrate measured after 1 hr by ADP-glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483593(CHEMBL1687958)
Affinity DataIC50: 20nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 1A1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50507596(CHEMBL4532099)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CYP1A1 using 7-Ethoxyresorufin as substrate after 15 mins in presence of NADP+ by EROD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM7393(Indirubin-3 -monoxime | 3-[(2Z,3E)-3-(hydroxyimino...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483585(CHEMBL1689308)
Affinity DataIC50: 24nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50188337(CHEMBL2058057)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483586(CHEMBL1689309)
Affinity DataIC50: 27nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sterling Road

Curated by ChEMBL
LigandPNGBDBM50293309(N-(4-(ethylsulfonamido)phenethyl)-2-(2,4-dichlorop...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human CYP1A2 expressed in yeast microsomal membranes using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin/7-ethoxy-methyloxy-3-cyanocoumari...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50483574(CHEMBL1689310)
Affinity DataIC50: 31nMAssay Description:Inhibition of Human immunodeficiency virus 1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50239035(CHEMBL4081914)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
Birla Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50239038(CHEMBL4074105)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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