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TargetAurora kinase B(Human)
Jawaharlal Nehru Centre For Advanced Scientific Research

LigandPNGBDBM189379(5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-di...)
Affinity DataKd:  1.14E+3nMpH: 8.0 T: 2°CAssay Description:Calorimetric titrations were performed in a Microcal iTC 200 microcalorimeter. Freshly purified 5 µM protein (Aurora A/B kinases) was titrated agains...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Jawaharlal Nehru Centre For Advanced Scientific Research

LigandPNGBDBM189380(5-methyl-4-(2-thiazolylazo)resorcinol | PTK66)
Affinity DataKd:  1.75E+3nMpH: 8.0 T: 2°CAssay Description:Calorimetric titrations were performed in a Microcal iTC 200 microcalorimeter. Freshly purified 5 µM protein (Aurora A/B kinases) was titrated agains...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Jawaharlal Nehru Centre For Advanced Scientific Research

LigandPNGBDBM189380(5-methyl-4-(2-thiazolylazo)resorcinol | PTK66)
Affinity DataKd:  500nMpH: 8.0 T: 2°CAssay Description:Calorimetric titrations were performed in a Microcal iTC 200 microcalorimeter. Freshly purified 5 µM protein (Aurora A/B kinases) was titrated agains...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50455630(CHEMBL4216648)
Affinity DataEC50:  5.30nMAssay Description:Inhibition of HIV1 NL4-3 protease assessed as decrease in viral replication in human MT2 cells after 4 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50455631(CHEMBL4208792)
Affinity DataEC50:  1.80nMAssay Description:Inhibition of HIV1 NL4-3 protease assessed as decrease in viral replication in human MT2 cells after 4 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataEC50:  0.700nMAssay Description:Inhibition of HIV1 NL4-3 protease assessed as decrease in viral replication in human MT2 cells after 4 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50134706(5-{2-[4-(2-Biphenyl-2-yl-2-hydroxy-acetylamino)-5-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Compound was tested for its effective concentration against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50134705(5-{2-[4-(2-Biphenyl-2-yl-2-hydroxy-acetylamino)-5-...)
Affinity DataEC50:  4.00E+3nMAssay Description:Compound was tested for its effective concentration against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM25406(4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...)
Affinity DataKd:  27nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM50225216(2-(2,4-dichlorophenoxy)-5-(hydroxymethyl)phenol | ...)
Affinity DataKd:  0.300nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM50225219(3-methoxy-4-phenoxybenzaldehyde | CHEMBL241453)
Affinity DataKd:  88nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)
Affinity DataKd:  1.44E+5nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM50225224(4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde | CH...)
Affinity DataKd:  13.9nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM50225226(4-(2,4-dichlorophenoxy)-3-methoxybenzoic acid | CH...)
Affinity DataKd:  0.200nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM50225228(3-hydroxy-4-phenoxybenzoic acid | CHEMBL241454)
Affinity DataKd:  27nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM50225217(5-(chloromethyl)-2-(2,4-dichlorophenoxy)phenol | C...)
Affinity DataKd:  5.70nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM50225221(2,3,6-trichloro-N-(4H-1,2,4-triazol-3-yl)benzamide...)
Affinity DataKd:  120nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
Institute of Sciences

Curated by ChEMBL
LigandPNGBDBM50225229(2-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol | CHEMBL...)
Affinity DataKd:  42nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSonic hedgehog protein(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50324671(Purmorphamine | CHEMBL1221984)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone H4(Human)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397030(CHEMBL2171189)
Affinity DataKd:  2.38E+4nMAssay Description:Binding affinity to fluorescein-labeled Histone H4(1-20) by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Bhupat and Jyoti Mehta School of Biosciences

Curated by ChEMBL
LigandPNGBDBM50038649(ML-3000 | [2-(4-Chloro-phenyl)-6,6-dimethyl-1-phen...)
Affinity DataEC50:  100nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16250(CHEMBL290001 | tert-butyl N-[(1S)-1-{[(1S)-1-{[(1R...)
Affinity DataIC50: 2nMAssay Description:Compound was tested for its inhibitory activity against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16047(EVNXXAEF | N-{(2R,4S,5S)-5-[(L-alpha-glutamyl-L-va...)
Affinity DataIC50: 2nMAssay Description:Compound was tested for its inhibitory activity against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302846(benzyl 3-((2R,3S)-3-acetamido-4-(3,5-difluoropheny...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523558(CHEMBL4460401)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523560(CHEMBL4300203)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523561(CHEMBL4437104)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523562(CHEMBL4474072)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523563(CHEMBL4554438)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523564(CHEMBL4525849)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523565(CHEMBL4542773)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523566(CHEMBL4574382)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523567(CHEMBL4522729)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523568(CHEMBL4447493)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50523569(CHEMBL4463796)
Affinity DataIC50: 4nMAssay Description:Inhibition of HIV1 protease activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM15797(3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[...)
Affinity DataIC50: 5nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 6(Human)
Allergan

US Patent
LigandPNGBDBM531086(US11208377, Compound 8 | (R)-6-chloro-3-((2-((2,2-...)
Affinity DataIC50: 6nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetC-C chemokine receptor type 6(Human)
Allergan

US Patent
LigandPNGBDBM531207(US11208377, Compound 109 | (R)-3-((3-chloro-2-hydr...)
Affinity DataIC50: 6nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetC-C chemokine receptor type 6(Human)
Allergan

US Patent
LigandPNGBDBM531125(US11208377, Compound 29 | (R)-3-((2-((5,5-dimethyl...)
Affinity DataIC50: 8nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328048(CHEMBL1257185)
Affinity DataIC50: 8nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302862(N-((2S,3R)-4-((R)-3-(3-tert-butylphenyl)-6-(hydrox...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 6(Human)
Allergan

US Patent
LigandPNGBDBM531139(US11208377, Compound 43 | 6-chloro-3-((2-((2,2-dim...)
Affinity DataIC50: 9nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328038(N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(1-(...)
Affinity DataIC50: 9nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 6(Human)
Allergan

US Patent
LigandPNGBDBM531128(US11208377, Compound 32 | (R)-6-chloro-3-((2-((5,5...)
Affinity DataIC50: 12nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328030(N-((2S,3R)-4-(1-(3-tert-butyl-5-(methylsulfonamido...)
Affinity DataIC50: 12nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328047(N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(1-(...)
Affinity DataIC50: 12nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378120(CHEMBL609987)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 6(Human)
Allergan

US Patent
LigandPNGBDBM531113(US11208377, Compound 17 | 6-chloro-3-((3,4-dioxo-2...)
Affinity DataIC50: 14nMAssay Description:HEK-Gqi5 cells stably expressing human CCR6 were cultured in DMEM high glucose, 10% FBS, 1% PSA, 400 ug/ml geneticin and 50 ug/ml hygromycin. Appropr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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