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TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527158(CHEMBL4476366)
Affinity DataKi:  40nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527145(CHEMBL4460705)
Affinity DataKi:  60nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527154(CHEMBL4454255)
Affinity DataKi:  90nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527152(CHEMBL4573064)
Affinity DataKi:  170nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527152(CHEMBL4573064)
Affinity DataKi:  170nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527149(CHEMBL4565963)
Affinity DataKi:  310nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527146(CHEMBL4538853)
Affinity DataKi:  430nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527148(CHEMBL4461955)
Affinity DataKi:  680nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527153(CHEMBL4469948)
Affinity DataKi:  2.00E+3nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527150(CHEMBL4541973)
Affinity DataKi:  3.40E+3nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527157(CHEMBL4452801)
Affinity DataKi:  3.70E+3nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527160(CHEMBL4475105)
Affinity DataKi:  4.40E+3nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527144(CHEMBL4587557)
Affinity DataKi:  1.53E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527156(CHEMBL4551451)
Affinity DataKi: >4.00E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527151(CHEMBL4440179)
Affinity DataKi: >4.00E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527147(CHEMBL4592796)
Affinity DataKi: >4.00E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527155(CHEMBL4439901)
Affinity DataKi: >5.30E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527159(CHEMBL4560817)
Affinity DataKi:  6.70E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610453(2-Phenyl-N-(4-(2,2,2-trifluoroethoxy)pyridin-3-yl)...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  0.0900nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610486(2-(Cyclohex-1-en-1-yl)-N-(4-(4,4-difluoropiperidin...)
Affinity DataIC50:  0.100nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50613245(CHEMBL5266553)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610459(N-(4-(4-Cyanopiperidin-1-yl)pyridin-3-yl)-2-phenyl...)
Affinity DataIC50:  0.100nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610453(2-Phenyl-N-(4-(2,2,2-trifluoroethoxy)pyridin-3-yl)...)
Affinity DataIC50:  0.100nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50613418(CHEMBL5268185)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610483(2-Cyclopropyl-N-(4-(4,4-difluoropiperidin-1-yl)pyr...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610461(N-(4-(4,4-Difluoropiperidin-1-yl)pyridin-3-yl)-2-p...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610462(N-(4-Morpholinopyridin-3-yl)-2-phenylimidazo[1,2-b...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610477(N-(4-Morpholinopyridin-3-yl)-2-(4-(trifluoromethyl...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610483(2-Cyclopropyl-N-(4-(4,4-difluoropiperidin-1-yl)pyr...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610459(N-(4-(4-Cyanopiperidin-1-yl)pyridin-3-yl)-2-phenyl...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610460(N-(4-(4-Fluoropiperidin-1-yl)pyridin-3-yl)-2-pheny...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610458(2-Phenyl-N-(4-(piperidin-1-yl)pyridin-3-yl)imidazo...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610473(N-(6-Fluoro-4-morpholinopyridin-3-yl)-2-phenylimid...)
Affinity DataIC50:  0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610462(N-(4-Morpholinopyridin-3-yl)-2-phenylimidazo[1,2-b...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610461(N-(4-(4,4-Difluoropiperidin-1-yl)pyridin-3-yl)-2-p...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610477(N-(4-Morpholinopyridin-3-yl)-2-(4-(trifluoromethyl...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610458(2-Phenyl-N-(4-(piperidin-1-yl)pyridin-3-yl)imidazo...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50613417(CHEMBL5290300)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50074676(CHEMBL3410091)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of GSK3beta (unknown origin) activity by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610453(2-Phenyl-N-(4-(2,2,2-trifluoroethoxy)pyridin-3-yl)...)
Affinity DataIC50:  0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610460(N-(4-(4-Fluoropiperidin-1-yl)pyridin-3-yl)-2-pheny...)
Affinity DataIC50:  0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610457(N-(4-(4-Cyanophenyl)pyridin-3-yl)-2-phenylimidazo[...)
Affinity DataIC50:  0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610469((S) N-(4-(3-Methylmorpholino)pyridin-3-yl)-2-pheny...)
Affinity DataIC50:  0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610469((S) N-(4-(3-Methylmorpholino)pyridin-3-yl)-2-pheny...)
Affinity DataIC50:  0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM610469((S) N-(4-(3-Methylmorpholino)pyridin-3-yl)-2-pheny...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50613246(CHEMBL5316226)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50613415(CHEMBL5273872)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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