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TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM22876(Sch 29851 | Claritin | CHEMBL998 | ethyl 4-{13-chl...)
Affinity DataKd:  190nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545588(CHEMBL4647890)
Affinity DataKd:  48nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545589(CHEMBL4647038)
Affinity DataKd:  28nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073179(CHEMBL1172 | Clarinex | Claritin-D | Claritin | SC...)
Affinity DataKd:  24nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545590(CHEMBL4645629)
Affinity DataKd:  454nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545591(CHEMBL4639563)
Affinity DataKd:  257nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545592(CHEMBL4637657)
Affinity DataKd:  51nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545593(CHEMBL4638183)
Affinity DataKd:  227nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545594(CHEMBL4649344)
Affinity DataKd:  423nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545595(CHEMBL4633258)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031236(CHEMBL3357023)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545596(CHEMBL4633111)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545597(CHEMBL4643460)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545598(CHEMBL4649552)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545599(CHEMBL4642056)
Affinity DataKd:  454nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545600(CHEMBL4641273)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545601(CHEMBL4646840)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545602(CHEMBL4634510)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545603(CHEMBL4633975)
Affinity DataKd:  271nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031281(CHEMBL3357022)
Affinity DataKd:  199nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545604(CHEMBL4634809)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545605(CHEMBL4648718)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545606(CHEMBL4649329)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545607(CHEMBL4632879)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545608(CHEMBL4632720)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50545609(CHEMBL4642460)
Affinity DataKd:  206nMAssay Description:Binding affinity to human H1 histamine receptor expressed in CHO cells after 1 hr by calcium 5 dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM276763(US10071992, Example 8 | US11034678, Example 8 | US...)
Affinity DataIC50: 3.30nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM276763(US10071992, Example 8 | US11034678, Example 8 | US...)
Affinity DataIC50: 3.30nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504497(US11065249, Example 11 | First-eluting enantiomer ...)
Affinity DataIC50: 4.40nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504497(US11065249, Example 11 | First-eluting enantiomer ...)
Affinity DataIC50: 4.40nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM50630285(CHEMBL5425575)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504419(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 5.80nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504419(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 5.80nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504424(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 8.60nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504424(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 8.60nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 10nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 10nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 11nMAssay Description:Inhibition of DGAT2 in human hepatocytes using 14C-glycerol as a substrate pre incubated for 45 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM276752(US10071992, Example 3.1 | 2-(5-((3-ethoxypyridin- ...)
Affinity DataIC50: 13nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM276752(US10071992, Example 3.1 | 2-(5-((3-ethoxypyridin- ...)
Affinity DataIC50: 13nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504482(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 17nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 17nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 17nMAssay Description:Inhibition of rat DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Trilux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504495(US11065249, Example 9 | First-eluting isomer (see ...)
Affinity DataIC50: 19nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504495(US11065249, Example 9 | First-eluting isomer (see ...)
Affinity DataIC50: 19nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504482(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 23nMAssay Description:Inhibition of DGAT2 in human hepatocytes using 14C-glycerol as a substrate pre incubated for 45 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM276761(US10071992, Example 6b | (S)-2-(5-((3-ethoxypyridi...)
Affinity DataIC50: 25nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

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