Report error Found 329 with Last Name = 'smith' and Initial = 'sc'
TargetMetabotropic glutamate receptor 1(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria
Curated by ChEMBL
Centro De Investigaci£N Lilly S.A. Avda. De La Industria
Curated by ChEMBL
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu1 stably expressed in golden hamster AV12 cell membrane co-expressing Gq assessed as assessed as increase i...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria
Curated by ChEMBL
Centro De Investigaci£N Lilly S.A. Avda. De La Industria
Curated by ChEMBL
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu5 stably expressed in golden hamster AV12 cell membrane co-expressing Gq assessed as assessed as increase i...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as increase in forskolin-stim...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu4 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu4 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as incr...More data for this Ligand-Target Pair
Affinity DataEC50: >1.25E+4nMAssay Description:Agonist activity at recombinant human mGlu6 receptor expressed in hamster AV12 cells co-expressing EAAT1 assessed as induction of forskolin-stimulate...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria
Curated by ChEMBL
Centro De Investigaci£N Lilly S.A. Avda. De La Industria
Curated by ChEMBL
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu5 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu6 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as incr...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as increase in forskolin-stim...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu7 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as induction of forskolin-sti...More data for this Ligand-Target Pair
Affinity DataEC50: 1.77E+3nMAssay Description:Antagonist activity at human recombinant mGlu8 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as reduction in ...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria
Curated by ChEMBL
Centro De Investigaci£N Lilly S.A. Avda. De La Industria
Curated by ChEMBL
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu1 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as asse...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged insulin receptor expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Agonist activity at mGlu3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-tagged insulin receptor expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Agonist activity at mGlu2 (unknown origin)More data for this Ligand-Target Pair


















3D Structure (crystal)













