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LigandPNGBDBM50110039(1-[2-(3-Cyclopropylmethoxy-4-methoxy-phenyl)-propy...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  11nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50399088(CHEMBL2179319)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  26nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
LigandPNGBDBM50451480(CHEMBL2093042)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50194617(CHEMBL3926416)
Affinity DataKi:  150nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50110030(1-{2-[3-(Indan-2-yloxy)-4-methoxy-phenyl]-propyl}-...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...More data for this Ligand-Target Pair
LigandPNGBDBM50366802(CHEMBL1788264)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]rolipram from rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547789(CHEMBL4794209)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataIC50:  0.646nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547752(CHEMBL4797113)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547769(CHEMBL4758144)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547790(CHEMBL4754478)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547765(CHEMBL4783572)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547766(CHEMBL4788385)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50085599(CHEMBL3427725 | US11419874, Example 29)
Affinity DataIC50:  3nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547751(CHEMBL4755779)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547775(CHEMBL4742646)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136661((R)-2-Amino-1-[(S)-2-(5-propyl-1H-imidazol-2-yl)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121279(2-Amino-1-[2-(5-ethyl-1H-imidazol-2-yl)-2,3-dihydr...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136662((S)-2-Amino-1-[(S)-2-(5-propyl-1H-imidazol-2-yl)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136644((S)-2-Amino-1-[(S)-5-chloro-2-(5-propyl-1H-imidazo...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50085602(CHEMBL3427722)
Affinity DataIC50:  6nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121284(2-Amino-1-[2-(5-methyl-1H-imidazol-2-yl)-2,3-dihyd...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136648((S)-2-Amino-1-[(S)-2-(5-propyl-1H-imidazol-2-yl)-2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121282((S)-1-((S)-2-aminobutanoyl)-N-butylindoline-2-carb...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50085598(CHEMBL3425534)
Affinity DataIC50:  10nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547778(CHEMBL4761452)
Affinity DataIC50:  10nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547767(CHEMBL4761967)
Affinity DataIC50:  10nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50219313(CHEMBL157812)
Affinity DataIC50: <10nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136667(2-Amino-1-[(S)-5-chloro-2-(5-propyl-1H-imidazol-2-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50085693(CHEMBL1915969 | US9540379, 32)
Affinity DataIC50:  14nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50085656(CHEMBL3425540 | US11419874, Example 12)
Affinity DataIC50:  15nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136645((S)-2-Amino-1-[(S)-5-methoxy-2-(5-propyl-1H-imidaz...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50549046(CHEMBL4741417)
Affinity DataIC50:  17nMAssay Description:Inhibition of OGA in HEK293 cells induced with human Tau P30IL mutant assessed as increase in O-GlcNAcylated protein levels measured after 6 hrs by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50549046(CHEMBL4741417)
Affinity DataIC50:  17nMAssay Description:Inhibition of OGA in HEK293 cells induced with human Tau P30IL mutant assessed as increase in O-GlcNAcylated protein levels measured after 6 hrs by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50110030(1-{2-[3-(Indan-2-yloxy)-4-methoxy-phenyl]-propyl}-...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50451480(CHEMBL2093042)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136654((S)-2-Amino-3-methyl-1-[(S)-2-(5-propyl-1H-imidazo...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50085600(CHEMBL3427724)
Affinity DataIC50:  21nMAssay Description:Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50110052(1-{2-[3-(Bicyclo[2.2.1]hept-2-yloxy)-4-methoxy-phe...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50110046(1-[2-(3-Cyclopropylmethoxy-4-difluoromethoxy-pheny...)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121285((S)-2-Amino-1-[(S)-2-(5-ethyl-1H-imidazol-2-yl)-2,...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50121280(2-Amino-1-[2-(5-methyl-1H-imidazol-2-yl)-2,3-dihyd...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity of the compound against tripeptidyl peptidase II purified from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547787(CHEMBL4797527)
Affinity DataIC50:  24nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547764(CHEMBL4740457)
Affinity DataIC50:  24nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50110038(1-{2-Fluoro-2-[3-(indan-2-yloxy)-4-methoxy-phenyl]...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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