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TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataEC50:  0.180nMAssay Description:Agonist activity at RLuc8-fused Go-coupled human D3R expressed in HEK293 cells untagged beta1 and mVenus-tagged gamma2 measured after 5 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiaz...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(2) dopamine receptor(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50322229(4-(4-Iodophenyl)-1-((4-methoxy-1H-indol-3-yl)methy...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiaz...)
Affinity DataKi:  0.940nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443390(CHEMBL1474387)
Affinity DataIC50: 0.960nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at RLuc8-fused Go-coupled human D3R expressed in HEK293 cells untagged beta1 and mVenus-tagged gamma2 measured after 5 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiaz...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527972(CHEMBL4476784 | US11634404, Compound 1)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at RLuc8-fused human D3R expressed in HEK293 cells co-expressing N-terminal Venus-tagged beta-arrestin2 and GRK3 assessed as inducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50322839(rac-N-(3-methyl-1-morpholinopentan-3-yl)-N-((1-met...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered sal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443390(CHEMBL1474387)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50322839(rac-N-(3-methyl-1-morpholinopentan-3-yl)-N-((1-met...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443406(CHEMBL3086823)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  2.30nMAssay Description:Agonist activity at RLuc8-fused human D3R expressed in HEK293 cells co-expressing N-terminal Venus-tagged beta-arrestin2 and GRK3 assessed as inducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  2.90nMAssay Description:Agonist activity at human D3R stably expressed in CHOK1 cells assessed as increase in ERK1/2 phosphorylation measured after 15 mins by AlphaScreen su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528020(CHEMBL4455456 | US11634404, Compound 78)
Affinity DataEC50:  3nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528020(CHEMBL4455456 | US11634404, Compound 78)
Affinity DataEC50:  3nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528020(CHEMBL4455456 | US11634404, Compound 78)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443409(CHEMBL3086836)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443408(CHEMBL3086837)
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443400(CHEMBL3086821)
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443390(CHEMBL1474387)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50527993(CHEMBL4458958 | US11634404, Compound 74)
Affinity DataEC50:  4.30nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528069(CHEMBL4459426 | US11634404, Compound 20)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528069(CHEMBL4459426 | US11634404, Compound 20)
Affinity DataEC50:  4.30nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527973(CHEMBL4472628 | US11634404, Compound 80)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50527973(CHEMBL4472628 | US11634404, Compound 80)
Affinity DataEC50:  4.40nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50527973(CHEMBL4472628 | US11634404, Compound 80)
Affinity DataEC50:  4.40nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as increase in inositol1-phosphate accumulation measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443405(CHEMBL3086824)
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50116766((6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiaz...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]-methylspiperon from human D2RL expressed in HEK293 cell membranes measured after 90 mins by topcount assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLuciferin 4-monooxygenase(Heike firefly)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50352641(CHEMBL1733803)
Affinity DataIC50: 5nMAssay Description:Inhibition of fire fly luciferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527999(CHEMBL4554045 | US11634404, Compound 108)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50527999(CHEMBL4554045 | US11634404, Compound 108)
Affinity DataEC50:  5nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50527999(CHEMBL4554045 | US11634404, Compound 108)
Affinity DataEC50:  5nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443391(CHEMBL469695)
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered sal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiaz...)
Affinity DataEC50:  5.40nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50116766((6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiaz...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer containing NaCl by topcount as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443404(CHEMBL3086825)
Affinity DataIC50: 5.70nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443392(CHEMBL1472563)
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50527993(CHEMBL4458958 | US11634404, Compound 74)
Affinity DataEC50:  6.40nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50527993(CHEMBL4458958 | US11634404, Compound 74)
Affinity DataEC50:  6.40nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  6.40nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50527993(CHEMBL4458958 | US11634404, Compound 74)
Affinity DataEC50:  6.40nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50322839(rac-N-(3-methyl-1-morpholinopentan-3-yl)-N-((1-met...)
Affinity DataIC50: 6.70nMAssay Description:Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528018(CHEMBL4575155 | US11634404, Compound 76)
Affinity DataEC50:  6.90nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528018(CHEMBL4575155 | US11634404, Compound 76)
Affinity DataEC50:  6.90nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

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