Compile Data Set for Download or QSAR
Report error Found 47 with Last Name = 'staker' and Initial = 'bl'
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443770(CHEMBL3094104)
Affinity DataKd:  7.00E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443771(CHEMBL3094103)
Affinity DataKd:  1.48E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443772(CHEMBL1230597)
Affinity DataKd:  1.80E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443775(CHEMBL3094105)
Affinity DataKd:  2.00E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50194153(5'-CDP | Cytidine 5'-pyrophosphate | CDP | Cytidin...)
Affinity DataKd:  7.50E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443773(CHEMBL1230528)
Affinity DataKd:  1.35E+5nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Burkholderia pseudomallei (strain K96243))
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50443774(CHEMBL3094106)
Affinity DataKd:  9.00E+4nMAssay Description:Binding affinity to Burkolderia pseudomallei IspF by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36536(D153215)
Affinity DataEC50:  243nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36535(D157554)
Affinity DataEC50:  921nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36534(D156095)
Affinity DataEC50:  104nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Cgi Pharmaceuticals

LigandPNGBDBM36516(4-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...)
Affinity DataIC50: 1.90nM Kd:  1.5nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 7.62nM EC50:  4nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36533(D157555)
Affinity DataIC50: 9.38nM EC50:  108nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36531(D158963)
Affinity DataIC50: 23.4nM EC50:  223nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50073854(2,10-dihydroxy-12-(3,4,5-trihydroxy-6-hydroxymethy...)
Affinity DataIC50: 30nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321626(N-(2-chloro-5-(1-(3-(4-(6-chloro-3-methyl-2-oxo-2,...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36530(D157493)
Affinity DataIC50: 43.9nM EC50:  67nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 1(Human)
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50008935(CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...)
Affinity DataIC50: 50nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321625(N-(2-chloro-5-(2-(3-(4-(6-chloro-3-methyl-2-oxo-2,...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36532(D158885)
Affinity DataIC50: 101nM EC50:  795nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321627(N-(2-chloro-5-(4-(3-(4-(6-chloro-3-methyl-2-oxo-2,...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 1(Human)
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataIC50: 300nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321624(N-(2-chloro-5-(1-(3-(4-(6-chloro-3-methyl-2-oxo-2,...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36529(D156676)
Affinity DataIC50: 339nM EC50:  2.54E+3nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321623(N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Cgi Pharmaceuticals

LigandPNGBDBM36521(CID11852095 | 6-(tert-Butyl)-N-(2-methyl-3-(4-meth...)
Affinity DataIC50: 650nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM32203(cid_1923 | CHEMBL310555 | 8-quinolinol | quinolin-...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321622(N-(2-chloro-5-(6-oxo-1-(3-(4-(2-oxopyrrolidin-1-yl...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321620(N-(2-chloro-5-(6-oxo-1-(3-(4-(3-(trifluoromethyl)p...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321625(N-(2-chloro-5-(2-(3-(4-(6-chloro-3-methyl-2-oxo-2,...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of cathepsin S-mediated invariant chain degradation in human JY B-cells assessed as accumulation of p10 fragment by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethionine aminopeptidase 2(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50065785(2-Methyl-quinolin-8-ol | CHEMBL316892)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321621(N-(2-chloro-5-(6-oxo-1-(3-(4-(2-oxopyrrolidin-1-yl...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Cgi Pharmaceuticals

LigandPNGBDBM36518(CID46942382 | N-(2-Methyl-3-(4-methyl-6-((4-(morph...)
Affinity DataIC50: 2.69E+3nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Cgi Pharmaceuticals

LigandPNGBDBM36520(CID46942381 | 3-(tert-Butyl)-N-(2-methyl-3-(4-meth...)
Affinity DataIC50: 3.14E+3nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50164286(4-(5,11-Dioxo-5,6a,11,11a-tetrahydro-indeno[1,2-c]...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Cgi Pharmaceuticals

LigandPNGBDBM36517(CID 46942383 | 5-(3-Amino-2-methylphenyl)-1-methyl...)
Affinity DataIC50: 5.44E+3nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321626(N-(2-chloro-5-(1-(3-(4-(6-chloro-3-methyl-2-oxo-2,...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of cathepsin S-mediated invariant chain degradation in human JY B-cells assessed as accumulation of p10 fragment by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321627(N-(2-chloro-5-(4-(3-(4-(6-chloro-3-methyl-2-oxo-2,...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of cathepsin S-mediated invariant chain degradation in human JY B-cells assessed as accumulation of p10 fragment by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Cgi Pharmaceuticals

LigandPNGBDBM36519(CID46942384 | 5-(3-((4-(tert-Butyl)benzyl)amino)-2...)
Affinity DataIC50: 9.06E+3nMpH: 7.5 T: 2°CAssay Description:Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM32203(cid_1923 | CHEMBL310555 | 8-quinolinol | quinolin-...)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321619(N-(2-chloro-5-(6-oxo-1-(3-(pyrrolidin-1-yl)propyl)...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM76305(MLS002695956 | cid_2817 | 5-chloro-8-quinolinol | ...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50065785(2-Methyl-quinolin-8-ol | CHEMBL316892)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50211290(CHEMBL2407096)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Northern Illinois University

Curated by ChEMBL
LigandPNGBDBM50211290(CHEMBL2407096)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Universidade Estadual De Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50548088(CHEMBL3040038)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)