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TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM22320(ethyl 5-methoxy-1-methyl-2-(4-phenylpiperazin-1-yl...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM22321(ethyl 2-[4-(4-fluorophenyl)piperazin-1-yl]-5-hydro...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM22323(ethyl 2-(4-benzylpiperazin-1-yl)-5-hydroxy-1H-indo...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM22327(methyl 2-[(1-phenylethyl)amino]-1H-indole-3-carbox...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM22328(methyl 5-hydroxy-2-[(1-phenylethyl)amino]-1H-indol...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM22333(ethyl 5-hydroxy-2-(pyridin-3-ylamino)-1H-indole-3-...)
Affinity DatapH: 7.4 T: 2°CAssay Description:Purified 5-LO was added to reaction mix containing the test compounds. For efficient inhibition of 5-LO, low hydroperoxide levels are important. Glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24554(ethyl 2-{[4-chloro-6-(quinolin-6-ylamino)pyrimidin...)
Affinity DataEC50:  2.60E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24555(2-{[4-chloro-6-(2,3-dihydro-1H-inden-4-ylamino)pyr...)
Affinity DataEC50:  3.90E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24556(ethyl 2-{[4-chloro-6-(2,3-dihydro-1H-inden-4-ylami...)
Affinity DataEC50:  3.20E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24557(ethyl 2-({4-chloro-6-[(2,3-dimethylphenyl)amino]py...)
Affinity DataEC50:  1.80E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24558(ethyl 2-{[4-chloro-6-(quinolin-6-ylamino)pyrimidin...)
Affinity DataEC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24559(ethyl 2-{[4-chloro-6-(quinolin-6-ylamino)pyrimidin...)
Affinity DataEC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24560(2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidi...)
Affinity DataEC50:  4.10E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24562(ethyl 2-{[4-chloro-6-(quinolin-6-yloxy)pyrimidin-2...)
Affinity DataEC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM24566(JMC515449 Compound 1 | Wyeth 14,643 | 2-({4-chloro...)
Affinity DatapH: 7.4 T: 2°CAssay Description:For assays of intact cells, 5000,000 freshly isolated PMNL cells were resuspended in PGC buffer. After preincubation with the test compounds for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241079(CHEMBL4072936)
Affinity DataEC50:  340nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241080(CHEMBL4093640)
Affinity DataEC50:  170nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241082(CHEMBL4098909)
Affinity DataEC50:  2.90E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241086(CHEMBL4071919)
Affinity DataEC50:  260nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241088(CHEMBL4063293)
Affinity DataEC50:  120nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241104(CHEMBL4091019)
Affinity DataEC50:  5.30E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241109(CHEMBL4076701)
Affinity DataEC50:  100nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241110(CHEMBL4081891)
Affinity DataEC50:  3.80E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataEC50:  1.47E+4nMAssay Description:Transactivation of human GAL4-fused PPARgamma ligand binding domain expressed in HEL293T cells after 12 to 14 hrs by dual-glo luciferase reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241117(CHEMBL4095466)
Affinity DataEC50:  670nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241118(CHEMBL4068899)
Affinity DataEC50:  440nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241120(CHEMBL4104364)
Affinity DataEC50:  1.36E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241122(CHEMBL4094234)
Affinity DataEC50:  370nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241123(CHEMBL4067723)
Affinity DataEC50:  1.20E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241124(CHEMBL4078618)
Affinity DataEC50:  1.70E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241130(CHEMBL4096637)
Affinity DataEC50:  6.40E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241131(CHEMBL4072573)
Affinity DataEC50:  350nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241133(CHEMBL4079796)
Affinity DataEC50:  160nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241134(CHEMBL4104050)
Affinity DataEC50:  140nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241135(CHEMBL4060350)
Affinity DataEC50:  7.80nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241136(CHEMBL4088582)
Affinity DataEC50:  7.50E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241138(CHEMBL4069036)
Affinity DataEC50:  76nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10894(4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamid...)
Affinity DataEC50:  1.40E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241144(CHEMBL1300445)
Affinity DataEC50:  150nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241145(CHEMBL4100178)
Affinity DataEC50:  160nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241152(CHEMBL4073326)
Affinity DataEC50:  170nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241158(CHEMBL4064739)
Affinity DataEC50:  100nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241147(CHEMBL4084686)
Affinity DataEC50:  1.30E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241149(CHEMBL4102626)
Affinity DataEC50:  3.80E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241150(CHEMBL4094881)
Affinity DataEC50:  970nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241151(CHEMBL4087681)
Affinity DataEC50:  14nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241160(CHEMBL4095371)
Affinity DataEC50:  46nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241172(CHEMBL4097715)
Affinity DataEC50:  320nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241173(CHEMBL4084092)
Affinity DataEC50:  370nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241164(CHEMBL4088942)
Affinity DataEC50:  3.80E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
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