Compile Data Set for Download or QSAR
Found 741 with Last Name = 'sunder' and Initial = 's'
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035500((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035528(Acetic acid (E)-2-[((S)-1-{(S)-2-[4-(4-chloro-benz...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035498((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  12nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035535(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065147((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  18nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  20nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065158((R)-4-Benzyloxy-1-{(S)-3-methyl-2-[4-(morpholine-4...)
Affinity DataKi:  20nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035531(CHEMBL74332 | Isobutyric acid (E)-3-methyl-2-[((S)...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035530(CHEMBL74651 | Propionic acid (E)-3-methyl-2-[((S)-...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035532(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065157((R)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  34nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065161(Acetic acid 1-{(S)-3-methyl-2-[4-(morpholine-4-car...)
Affinity DataKi:  40nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065163((R)-3-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  70nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004711(3-Phenyl-2-(9-phenyl-2-propoxy-9H-purin-6-ylamino)...)
Affinity DataKi:  96nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065155(2-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-benzo...)
Affinity DataKi:  100nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065154(4-Hydroxy-1-{(S)-3-methyl-2-[4-(morpholine-4-carbo...)
Affinity DataKi:  120nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065146(1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-benzo...)
Affinity DataKi:  150nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035491(CHEMBL59091 | Morpholine-4-carboxylic acid {(S)-2-...)
Affinity DataKi:  190nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065164((S)-1-{(R)-3,3-Dimethyl-2-[4-(morpholine-4-carbony...)
Affinity DataKi:  240nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455626(CHEMBL2112507)
Affinity DataKi:  310nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035528(Acetic acid (E)-2-[((S)-1-{(S)-2-[4-(4-chloro-benz...)
Affinity DataKi:  320nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065156((S)-1-{(R)-3,3-Dimethyl-2-[4-(morpholine-4-carbony...)
Affinity DataKi:  340nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455625(CHEMBL2111718)
Affinity DataKi:  350nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455625(CHEMBL2111718)
Affinity DataKi:  350nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455625(CHEMBL2111718)
Affinity DataKi:  370nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455625(CHEMBL2111718)
Affinity DataKi:  370nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004715(3-Phenyl-2-(9-phenyl-2-propoxy-9H-purin-6-ylamino)...)
Affinity DataKi:  440nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004713((R)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  620nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455626(CHEMBL2112507)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065162((S)-1-{(R)-3,3-Dimethyl-2-[4-(morpholine-4-carbony...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455624(CHEMBL2112500)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004721((S)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035532(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004722((R)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004714((S)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065153((S)-1-[3-Methyl-2-(2-oxo-2-phenyl-ethyl)-butyryl]-...)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065151((S)-1-{(R)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004711(3-Phenyl-2-(9-phenyl-2-propoxy-9H-purin-6-ylamino)...)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035533(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  6.30E+3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035533(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  6.30E+3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50455624(CHEMBL2112500)
Affinity DataKi:  6.30E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004716((2R,3R)-2-Methyl-3,7-diphenyl-5-propoxy-2,7-dihydr...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035536((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  8.00E+3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004721((S)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004714((S)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  9.40E+3nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in whole rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065150((S)-1-[3-Methyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-b...)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004716((2R,3R)-2-Methyl-3,7-diphenyl-5-propoxy-2,7-dihydr...)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of of Bodipy-labelled cyclopamine binding to Smo expressed in COS-1 cells in presence of 20% NHS after 4 to 6 hrs by FACS flow cytometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065148(4-(Morpholine-4-carbonyl)-N-{(S)-2-oxo-1-[(S)-1-(3...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004715(3-Phenyl-2-(9-phenyl-2-propoxy-9H-purin-6-ylamino)...)
Affinity DataKi:  3.00E+4nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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