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TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452467(CHEMBL4218032)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545069(CHEMBL4636675)
Affinity DataEC50:  1.02E+7nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1-like(Human)
Cold Spring Harbor Laboratory

Curated by ChEMBL
LigandPNGBDBM50183448(CHEMBL3823478 | US11773085, Compound B2)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to biotinylated C-terminal Avi/His-TEV-fused BRD9 (unknown origin) expressed in Escherichia coli by isothermal titration calorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545076(CHEMBL4644184)
Affinity DataEC50:  2.50E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366212(CHEMBL1957617)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at androgen receptor expressed in Cos7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545041(CHEMBL4633509)
Affinity DataEC50:  7.70E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452469(CHEMBL4210169)
Affinity DataEC50:  270nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366211(CHEMBL1957616)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at androgen receptor expressed in Cos7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094844((+/-)-2-Amino-6-methyl-bicyclo[3.1.0]hexane-2,6-di...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545053(CHEMBL4633125)
Affinity DataEC50:  7.60E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452457(CHEMBL4213559)
Affinity DataEC50:  65nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452461(CHEMBL4214047)
Affinity DataEC50:  380nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus (strain A/Aichi/2/1968 H3N2))
Saitama University

Curated by ChEMBL
LigandPNGBDBM50360450(CHEMBL1934618)
Affinity DataEC50:  4.28E+5nMAssay Description:Inhibition of Human influenza virus A/Aichi/2/68 (H3N2) neuraminidase using 4-MU-Neu5Ac as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50:  62.8nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452465(CHEMBL4209251)
Affinity DataEC50:  530nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  45.4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452459(CHEMBL4209646)
Affinity DataEC50:  420nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452476(CHEMBL4206902)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50514905(CHEMBL4453849 | US12110278, Compound 7)
Affinity DataKd:  1.23E+4nMAssay Description:Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452458(CHEMBL4207138)
Affinity DataEC50:  120nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  94nMAssay Description:Binding affinity to human C-terminal His8-tagged JAK2 pseudokinase (513 to 827 residues) expressed in baculovirus infected Hi-5 cells by intrinsic tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545046(CHEMBL4644210)
Affinity DataEC50:  4.30E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452455(CHEMBL4215510)
Affinity DataEC50:  43nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545066(CHEMBL4647477)
Affinity DataEC50:  8.10E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094848((1S,2S,3R,5R,6S)-2-amino-3-fluorobicyclo[3.1.0]hex...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50514907(CHEMBL4449644 | US12110278, Compound 12)
Affinity DataKd:  6.60E+3nMAssay Description:Binding affinity to wild type human N-terminal TEV cleavage site-fused/His6-tagged JAK2 JH1 domain (840 to 1132 residues) expressed in baculovirus in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545073(CHEMBL4633649)
Affinity DataEC50:  3.30E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452474(CHEMBL4217523)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50514907(CHEMBL4449644 | US12110278, Compound 12)
Affinity DataKd:  346nMAssay Description:Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50366480(ATP | ADENOSINE TRIPHOSPHATE)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to wild type 6XHis-tagged human JAK2 JH2 domain (513 to 827 residues) expressed in baculovirus infected Sf9 cells by MANT-ATP bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545068(CHEMBL4636471)
Affinity DataEC50:  7.80E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452475(CHEMBL4218179)
Affinity DataEC50:  330nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545067(CHEMBL4633336)
Affinity DataEC50:  6.60E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545040(CHEMBL4639904)
Affinity DataEC50:  5.70E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279772(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Affinity DataEC50:  50.3nMAssay Description:Antagonist activity against Metabotropic glutamate receptor 2
expressed in CHO cells was evaluated in presence of 30 uM glutamic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452454(CHEMBL4216406)
Affinity DataEC50:  620nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452471(CHEMBL4214562)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50514901(CHEMBL4525245)
Affinity DataKd:  374nMAssay Description:Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452455(CHEMBL4215510)
Affinity DataEC50:  98nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545048(CHEMBL4639683)
Affinity DataEC50:  8.90E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094843((-)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Affinity DataEC50:  2.07nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545060(CHEMBL4638825)
Affinity DataEC50:  1.09E+7nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTaste receptor type 1 member 2/3(Human)
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50545042(CHEMBL4635470)
Affinity DataEC50:  9.50E+6nMAssay Description:Positive allosteric modulation of human TIR2/TIR3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Cold Spring Harbor Laboratory

Curated by ChEMBL
LigandPNGBDBM50183448(CHEMBL3823478 | US11773085, Compound B2)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452473(CHEMBL4205804)
Affinity DataEC50:  160nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50514909(CHEMBL4582077 | US12110278, Compound 5)
Affinity DataKd:  4.78E+4nMAssay Description:Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366227(CHEMBL1957726)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at androgen receptor expressed in Cos7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50366223(CHEMBL1957610)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at androgen receptor expressed in Cos7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50514902(CHEMBL4476380 | US12110278, Compound 10)
Affinity DataKd:  571nMAssay Description:Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50514911(CHEMBL4560164 | US12110278, Compound 14)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
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